Results 101 to 110 of about 171,997 (216)

The Crude Venom of the Whitetail Lancehead, Bothrops leucurus, and Two of Its Enzymatic Components Are Selectively Cytotoxic for Glioma Cells In Vitro

Journal of Applied Toxicology, EarlyView.
ABSTRACT Malignant glioma is the most common primary brain tumor, and glioblastoma multiforme (GBM) remains its most aggressive and incurable form. Snake venoms contain bioactive compounds with promising antitumoral properties against several cancer types.
M. O. H. V. Rosário, T. M. Fucase, P. J. Spencer, J. M. Sciani, J. Clarêncio, G. Rádis‐Baptista, L. L. Casais‐e‐Silva, R. S. El‐Bachá   +7 more
wiley   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Anti‐Erythrocyte Antibody Formation in Individuals With and Without Known Sensitisation Pathways Reflecting Indications for Extended Immunohaematology Screening

Journal of Clinical Laboratory Analysis, EarlyView.
– The yearly incidence of anti‐red blood cell antibodies stratified by participant groups and temporal evolution. – Overall significance p = 3.756 × 10−29. ABSTRACT Background Blood transfusion therapies are of vital importance for many patient groups.
Milanka Milosavić, Marko Lilić, Gordana Guzijan, Dušan Vučetić   +3 more
wiley   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source

Synthetic Ligands of Myeloid C-Type Lectin Receptors. [PDF]

Chembiochem
Suri J, Lepenies B.
europepmc   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

FOXC1: A Key Transcription Factor of VSMC‐Derived Foam Cell Formation in Atherosclerotic Plaque Instability

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The instability of atherosclerotic plaques, particularly intraplaque hemorrhage (IPH), drives life‐threatening cardiovascular events, a process in which vascular smooth muscle cell (VSMC)‐derived foam cells play a significant role. We aim to identify key biomarkers associated with VSMC‐derived foam cells and IPH by analyzing data from human ...
Ling‐Lin Qian, Xue‐Ling Li, Li‐Hong Wang, Wei Yang, Yu Jiang   +4 more
wiley   +1 more source

The C-Type Lectin Mincle Serves as a Pattern Recognition Receptor for the Lipid Envelope of Human Cytomegalovirus. [PDF]

Eur J Immunol
Bokun V, Chai W, Buchanan R, Murphy E, Liu Y, Holder B, Decout A.   +6 more
europepmc   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source