Results 111 to 120 of about 171,997 (216)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Covalent Activation of the C-type Lectin DC-SIGN. [PDF]

Angew Chem Int Ed Engl
Lefèbre J, Besch M, Csorba N, Garami K, Orgován Z, Schlosser G, Bermejo I, Ábrányi-Balogh P, Keserű GM, Rademacher C.   +9 more
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

ASGR2 and CLEC12A as Prognostically Relevant C-Type Lectin Hubs in Glioblastoma. [PDF]

Int J Mol Sci
Pace A, Alfano C, D'Angelo L, Napoletano C, Zizzari IG, Santoro A, Nuti M, Farina L, Petti M, Rughetti A.   +9 more
europepmc   +1 more source

Enhancing Ligand Epitope Mapping in Biomolecular Recognition by Variable Temperature Saturation Transfer Difference NMR (VT‐STD NMR)

Magnetic Resonance in Chemistry, EarlyView.
The impact of temperature on the analysis of STD NMR ligand epitope mapping has been thoroughly investigated. For protein–ligand complexes under fast exchange kinetics, a negligible temperature effect is observed. For the intermediate exchange regime, VT‐STD NMR allows to obtain better discriminated epitope mappings, hence enabling the accurate ...
Gabriel Rocha, Svetla Daskalova, Juan C. Muñoz‐García, Jesús Angulo   +3 more
wiley   +1 more source

A N-Acetyl-D-Glucosamine-Binding C-Type Lectin in the Cutaneous Mucus of Chub Mackerel, Scomber japonicus, Agglutinates Pathogenic Bacteria. [PDF]

Microbiol Immunol
Tsutsui S, Kunisaki T, Izawa T, Nakamura O.   +3 more
europepmc   +1 more source

Assessment of Lectin Staining Biomarkers for GNE Myopathy Gene Therapy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims GNE myopathy (GNEM) is a rare, autosomal recessive disorder caused by mutations in the UDP‐N‐acetylglucosamine (GlcNAc) 2‐epimerase/N‐acetylmannosamine (ManNAc) kinase (GNE) gene, which encodes a required enzyme for sialic acid (SA) biosynthesis.
Kristina M. Sattler, Brian J. Paleo, Mackenzie N. Roth, Kara E. Bradley, Megan N. Winkler, Wakako Yoshioka, Ichizo Nishino, Christoph Lepper, Kelly E. Crowe   +8 more
wiley   +1 more source

Ameliorative effects of <i>Toxocara canis</i> recombinant C-type lectin on atopic dermatitis in a mouse model. [PDF]

J Allergy Clin Immunol Glob
Jahani H, Jamshidi S, Jalousian F, Shokrpoor S, Nourizadeh M, Hosseini SH, Malekzadeh P, Boluki Z.   +7 more
europepmc   +1 more source

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

Correction to: Integrative multi-omics analysis identifies C-type lectin CNVs as functional targets for breeding mastitis-resistant dairy goats. [PDF]

Anim Microbiome
Yuan Y, Cong H, Ren T, Ruan PC, Xu L, Yang BG, Zhang HY, Ceccobelli S, Wang ZX, Liu YL, Kaushalendra, Han YG, Zeng Y, Miao H, Xu DJ, E GX.   +15 more
europepmc   +1 more source