Results 281 to 290 of about 243,058 (345)

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Effect of C-type lectin 16 on dengue virus infection in Aedes aegypti salivary glands. [PDF]

PNAS Nexus
Chang YC, Liu WL, Fang PH, Li JC, Liu KL, Huang JL, Chen HW, Kao CF, Chen CH.   +8 more
europepmc   +1 more source

Latent Neoehrlichia mikurensis Infections May Be Reactivated in Patients With B‐Cell Lymphomas Treated With Rituximab

Immunology, EarlyView.
Eight percent of this cohort of patients had a latent Neoehrlichia mikurensis infection. It was only the latently infected patients who had N. mikurensis‐specific T cells, not the matched B‐cell lymphoma patients without the infection. The T‐cell responses of latently infected patients included perforin‐expressing Th1 and CD8+ T cells that upregulated ...
Linda Wass, Catharina Lewerin, Daniel Jaén‐Luchoro, Christine Lingblom, Christine Wennerås   +4 more
wiley   +1 more source

The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer. [PDF]

Sci Rep
Trimaglio G, Sneperger T, Raymond BBA, Gilles N, Näser E, Locard-Paulet M, Ijsselsteijn ME, Brouwer TP, Ecalard R, Roelands J, Matsumoto N, Colom A, Habch M, de Miranda NFCC, Vergnolle N, Devaud C, Neyrolles O, Rombouts Y.   +17 more
europepmc   +1 more source

Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflammation via the Dectin1/Syk/CARD9/IRF5/NF‐κB pathway

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Inflammation plays an essential role in the pathogenesis of diabetic nephropathy (DN). Linderalactone (LNL), as a natural sesquiterpene lactone, has been discovered to have anti‐inflammatory activation. However, the effects of linderalactone on diabetes‐associated renal damage remain unclear.
Hao Chen, Sheng Xu, Bingrong Chen, Xishan Xiong, Jinrui Hu, Yuhong Wu, Tianrui Wang, Huishang Wang   +7 more
wiley   +1 more source

CsTs, a C-type lectin receptor-like kinase, regulates the development trichome development and cuticle metabolism in cucumber (Cucumis sativus). [PDF]

Hortic Res
Lv D, Wen H, Wang G, Liu J, Guo C, Sun J, Zhang K, Li C, You J, Pan M, He H, Cai R, Pan J.   +12 more
europepmc   +1 more source

Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Hair follicles (HFs) were extracted from skin biopsies. From these, original sequencing data were obtained and integrated with two independent studies to build a HF single‐cell transcriptomic atlas. It enabled delineating the fate of HF stem cells.
Audrey Onfroy, Francette Jean‐Louis, Philippe Le Corvoisier, Fanny Coulpier, Kévin Muret, Eric Bonnet, Raphaele Arrouasse, Caroline Boucle, Salwa Abid, Emilie Sbidian, Christina Bergqvist, Pierre Wolkenstein, Véronique Godot, Jean‐François Deleuze, Yves Lévy, Piotr Topilko, Etienne Audureau, Sophie Hue   +17 more
wiley   +1 more source

Identification of Podoplanin Aptamers by SELEX for Protein Detection and Inhibition of Platelet Aggregation Stimulated by C-Type Lectin-like Receptor 2. [PDF]

Biosensors (Basel)
Tsai HJ, Cheng KW, Li JC, Ruan TX, Chang TH, Wang JR, Tseng CP.   +6 more
europepmc   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, EarlyView.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

GENETIC ABLATION OF THE C-TYPE LECTIN RECEPTOR CLEC2D INCREASES PERITONITIS MORTALITY, INFLAMMATION, AND PHYSIOLOGY WITHOUT DIMINISHING ORGAN INJURY. [PDF]

Shock
Stolarski AE, Lai JJ, Kim J, Rock KL, Remick D.   +4 more
europepmc   +1 more source