Results 91 to 100 of about 108,848 (254)
Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity
Advanced Science, EarlyView.This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao +11 more
wiley +1 more source
PharmaceuticsBackground/Objectives: Nasal vaccines are a promising strategy for enhancing mucosal immune responses and preventing diseases at mucosal sites by stimulating the secretion of secretory IgA, which is crucial for early pathogen neutralization.
Mariana Colaço +3 more
doaj +1 more source
Sensing Tissue Damage by Myeloid C-Type Lectin Receptors
, 2019 After both sterile and infectious insults, damage is inflicted on tissues leading to accidental or programmed cell death. In addition, events of programmed cell death also take place under homeostatic conditions, such as in embryo development or in the turnover of hematopoietic cells. Mammalian tissues are seeded with myeloid immune cells, which harbor
Del Fresno, Carlos +2 more
openaire +3 more sources
Advanced Science, EarlyView.ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley +1 more source
Thermophobic Trehalose Glycopolymers as Smart C-Type Lectin Receptor Vaccine Adjuvants. [PDF]
Adv Healthc Mater, 2023 Hendricksen AT +12 more
europepmc +1 more source
Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity
Advanced Science, EarlyView.This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou +8 more
wiley +1 more source
Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand. [PDF]
Front Immunol, 2023 Holder A +9 more
europepmc +1 more source
SELECTIVE GLYCOMIMETIC LIGANDS OF C-TYPE LECTIN RECEPTORS
, 2023 C-type lectin receptors (CLRs) are calcium-dependent proteins dedicated to sensing glycan motifs, including those expressed on the surface of invading pathogens. Although this recognition event usually leads to induction of an immune response, many pathogens have evolved mechanisms to exploit lectins to promote infection.
openaire +1 more source
Advanced Science, EarlyView.This review presents a process‐oriented framework for vascularized cardiac tissue engineering, highlighting how the coordinated design of cells, biomaterials, and biofabrication strategies enables the functional development or vascularized myocardium for disease modelling and drug discovery.
Yang Liu +9 more
wiley +1 more source
C-Type Lectin Receptor Mediated Modulation of T2 Immune Responses to Allergens. [PDF]
Curr Allergy Asthma Rep, 2023 Angelina A +4 more
europepmc +1 more source