Results 41 to 50 of about 25,168,555 (296)

Dendritic Cell Activating Receptor 1 (DCAR1) Associates With FcεRIγ and Is Expressed by Myeloid Cell Subsets in the Rat

Frontiers in Immunology, 2019
Dendritic cell activating receptor-1 (DCAR1) is a cell-surface receptor encoded by the Antigen Presenting Lectin-like gene Complex (APLEC). We generated a mouse monoclonal antibody against rat DCAR1, and used this to characterize receptor expression and ...
Michael R. Daws, Britt Nakken, Ana Lobato-Pascual, Régis Josien, Régis Josien, Erik Dissen, Sigbjørn Fossum   +6 more
doaj   +1 more source

Antifungal immunity mediated by C-type lectin receptors may be a novel target in immunotherapy for urothelial bladder cancer

Frontiers in Immunology, 2022
Immunotherapies, such as immune-checkpoint blockade and adoptive T-cell therapy, offer novel treatment options with good efficacy for patients with urothelial bladder cancer.
Tianhang Li, Tianyao Liu, Zihan Zhao, Yuchen Pan, Xinyan Xu, Yulin Zhang, Shoubin Zhan, Shengkai Zhou, Wenjie Zhu, Hongqian Guo, Rong Yang   +10 more
doaj   +1 more source

Mannose-recognition mutant of the galactose/N-acetylgalactosamine-specific C-type lectin CEL-I engineered by site-directed mutagenesis [PDF]

, 2015
Background CEL-I is a galactose/N-acetylgalactosamine-specific C-type lectin isolated from the sea cucumber Cucumaria echinata. Its carbohydrate-binding site contains a QPD (Gln-Pro-Asp) motif, which is generally recognized as the galactose specificity ...
Hatakeyama, Tomomitsu, Hirabayashi, Jun, Moriuchi, Hiromi, Tateno, Hiroaki, Unno, Hideaki, Goda, Shuichiro   +5 more
core   +1 more source

Signaling C-type lectin receptors in antimycobacterial immunity

PLOS Pathogens, 2017
The mammalian innate immune system is composed of phagocytes such as macrophages and dendritic cells that serve as the first line of defense against microbial infections. These cells express various pattern recognition receptors (PRRs) that recognize specific pathogen-associated molecular patterns (PAMPs) on the surface of or inside microorganisms [1].
Mohlopheni J. Marakalala, Hlumani Ndlovu
openaire   +5 more sources

Investigation of asialoglycoprotein receptor glycosylation by lectin affinity methods [PDF]

Journal of the Serbian Chemical Society, 2002
The asialoglycoprotein receptor belongs to the family of calcium-dependent (C-type) animal lectins. The purified receptor is a glycoprotein in which 10 % of the dry weight consists of sialic acid, galactose, N-acetylglucosamine and mannose.
MARGITA CUPERLOVIC, VESNA MARINOVIC, LJILJANA VISOVAC, IVONA BARICEVIC   +3 more
doaj  

Mannose-binding lectin 2 polymorphisms do not influence frequency or type of infection in adults with chemotherapy induced neutropaenia. [PDF]

, 2012
BACKGROUND: Mannose-binding Lectin protein (MBL) has been suggested to be relevant in the defence against infections in immunosuppressed individuals.
Öhrmalm, Lars, Michelle Wong, Ohrmalm, L, Öhrmalm L., Lars Öhrmalm, Aust Carl, Tolfvenstam, Thomas, Tolfvenstam T., Hibberd, Martin, Wong, Michelle, Martin Hibberd, Hibberd M., Broliden K., Tolfvenstam, T,, Hibberd, M, Kristina Broliden, Thomas Tolfvenstam, Broliden, K,, Broliden, Kristina, Hibberd Martin, Broliden Kristina, Aust, C,, Wong, M, Carl Aust, Aust C., Wong M., Tolfvenstam Thomas, Öhrmalm Lars, Wong Michelle, Aust, Carl   +29 more
core   +2 more sources

An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides

Journal for ImmunoTherapy of Cancer, 2018
Background Receptors specific for the sugar N-acetylgalactosamine (GalNAc) include the human type II, C-type lectin receptor macrophage galactose-type lectin/C-type lectin receptor family member 10A (MGL/CLEC10A/CD301) that is expressed prominently by ...
Laura L. Eggink, Katherine F. Roby, Robert Cote, J. Kenneth Hoober   +3 more
doaj   +1 more source

C‐type lectin‐like receptors on myeloid cells

Annals of Medicine, 2006
Host defence against pathogens requires the recognition of conserved microbial molecules, or 'pathogen-associated molecular patterns' (PAMPs), by their receptors termed 'pattern recognition receptors' (PRRs), represented most notably by toll-like receptors (TLRs) and C-type lectins.
Elwira, Pyz, Andrew S J, Marshall, Siamon, Gordon, Gordon D, Brown   +3 more
openaire   +2 more sources

Information transfer in mammalian glycan-based communication

eLife, 2023
Glycan-binding proteins, so-called lectins, are exposed on mammalian cell surfaces and decipher the information encoded within glycans translating it into biochemical signal transduction pathways in the cell.
Felix F Fuchsberger, Dongyoon Kim, Natalia Baranova, Hanka Vrban, Marten Kagelmacher, Robert Wawrzinek, Christoph Rademacher   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source