Results 21 to 30 of about 115,349 (202)

Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia

Haematologica, 2010
Background C-type lectin-like molecule-1 is a transmembrane receptor expressed on myeloid cells, acute myeloid leukemia blasts and leukemic stem cells.
Xiaoxian Zhao, Shweta Singh, Cecile Pardoux, Jingsong Zhao, Eric D. Hsi, Arie Abo, Wouter Korver   +6 more
doaj   +1 more source

C-type lectin receptors orchestrate antifungal immunity [PDF]

Nature Immunology, 2012
Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family.
Sarah E, Hardison, Gordon D, Brown
openaire   +2 more sources

Computational Analysis of the Ligand Binding Site of the Extracellular ATP Receptor, DORN1. [PDF]

PLoS ONE, 2016
DORN1 (also known as P2K1) is a plant receptor for extracellular ATP, which belongs to a large gene family of legume-type (L-type) lectin receptor kinases.
Cuong The Nguyen, Kiwamu Tanaka, Yangrong Cao, Sung-Hwan Cho, Dong Xu, Gary Stacey   +5 more
doaj   +1 more source

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Bee K. Tan, Robert B. Sim, Russell Wallis, Tan, Bee K., Elizabeth J. Soilleux, Townsend, Paul, Wallis, Russell, Soilleux, Elizabeth J., Paul Townsend, Daniel A. Mitchell, Randeva, Harpal S., Sim, Robert B., Hendrik Lehnert, Ilyas, Rebecca, Zehnder, Daniel, Mitchell, Daniel A., Daniel Zehnder, Rebecca Ilyas, Harpal S. Randeva, Lehnert, Hendrik   +19 more
core   +1 more source

A Proposal for Nomenclature in Myeloid C-Type Lectin Receptors [PDF]

Frontiers in Immunology, 2019
Myeloid C-type lectin receptors (CLRs) comprise a family of receptors expressed by immune myeloid cells that share homologous C-type lectin domains. The implication of these CLRs in the regulation of homeostasis and activation of myeloid cells has generated a buoyant growth in the number of studies involving these receptors.
del Fresno, Carlos, Cueto, Francisco J., Sancho, David   +2 more
openaire   +4 more sources

Key thermally dimorphic fungal pathogens: shaping host immunity

Open Biology, 2022
Exposure to fungal pathogens from the environment is inevitable and with the number of at-risk populations increasing, the prevalence of invasive fungal infection is on the rise. An interesting group of fungal organisms known as thermally dimorphic fungi
Maxine A. Höft, Lucian Duvenage, J. Claire Hoving   +2 more
doaj   +1 more source

Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists

Communications Biology, 2023
Fluorescence correlation spectroscopy on crosslinked nanobodies tested on C-type lectin-like receptor 2 (CLEC-2) show different outcomes for divalent and tetravalent nanobody ligands on CLEC-2 clustering, also dependent on CLEC-2 expression levels.
Joanne C. Clark, Eleyna M. Martin, Luis A. Morán, Ying Di, Xueqing Wang, Malou Zuidscherwoude, Helena C. Brown, Deirdre M. Kavanagh, Johan Hummert, Johannes A. Eble, Bernhard Nieswandt, David Stegner, Alice Y. Pollitt, Dirk-Peter Herten, Michael G. Tomlinson, Angel García, Steve P. Watson   +16 more
doaj   +1 more source

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2 [PDF]

, 2008
Background: The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCc2 in platelets downstream of GPVI/FcRc and the C-type lectin receptor CLEC-2.
Pearce, AC, Watson, Steve P, Watson, Steve P., Eble, JA, Pearce, Andrew C., Pearce, A C, Hughes, C E, McGlade, Jane, Eble, Johannes A., Auger, Jocelyn; id_orcid, McGlade, J, Auger, Jocelyn M., Watson, Steve; id_orcid, Eble, J A, Pearce, Andrew C, Auger, J M, Watson, S P, Hughes, Craig, Hughes, C.E, Hughes, Craig E.   +19 more
core   +1 more source

The Vi Capsular Polysaccharide of Salmonella Typhi Promotes Macrophage Phagocytosis by Binding the Human C-Type Lectin DC-SIGN

mBio, 2022
Capsular polysaccharides are common virulence factors of extracellular, but not intracellular bacterial pathogens, due to the antiphagocytic properties of these surface structures.
Lillian F. Zhang, Bernd Lepenies, Sayuri Nakamae, Briana M. Young, Renato L. Santos, Manuela Raffatellu, Brian A. Cobb, Hirotaka Hiyoshi, Andreas J. Bäumler   +8 more
doaj   +1 more source

The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure

Nature Communications, 2020
The molecular mechanisms that drive irreversible acute liver failure remain poorly characterized. Here, the authors show that the recently discovered platelet receptor CLEC-2 (C-type lectin-like receptor) perpetuates and worsens liver damage during acute
Abhishek Chauhan, Lozan Sheriff, Mohammed T. Hussain, Gwilym J. Webb, Daniel A. Patten, Emma L. Shepherd, Robert Shaw, Christopher J. Weston, Debashis Haldar, Samuel Bourke, Rajan Bhandari, Stephanie Watson, David H. Adams, Steve P. Watson, Patricia F. Lalor   +14 more
doaj   +1 more source