Results 11 to 20 of about 111,532 (208)

Comparative transcriptomics reveals the immune dynamics during the molting cycle of swimming crab Portunus trituberculatus

open access: yesFrontiers in Immunology, 2022
Molting is one of the most important biological processes of crustacean species, and a number of molecular mechanisms facilitate this complex procedure. However, the understanding of the immune mechanisms underlying crustacean molting cycle remains very ...
Meimei Liu   +6 more
doaj   +1 more source

Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia

open access: yesHaematologica, 2010
Background C-type lectin-like molecule-1 is a transmembrane receptor expressed on myeloid cells, acute myeloid leukemia blasts and leukemic stem cells.
Xiaoxian Zhao   +6 more
doaj   +1 more source

Computational Analysis of the Ligand Binding Site of the Extracellular ATP Receptor, DORN1. [PDF]

open access: yesPLoS ONE, 2016
DORN1 (also known as P2K1) is a plant receptor for extracellular ATP, which belongs to a large gene family of legume-type (L-type) lectin receptor kinases.
Cuong The Nguyen   +5 more
doaj   +1 more source

Key thermally dimorphic fungal pathogens: shaping host immunity

open access: yesOpen Biology, 2022
Exposure to fungal pathogens from the environment is inevitable and with the number of at-risk populations increasing, the prevalence of invasive fungal infection is on the rise. An interesting group of fungal organisms known as thermally dimorphic fungi
Maxine A. Höft   +2 more
doaj   +1 more source

Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists

open access: yesCommunications Biology, 2023
Fluorescence correlation spectroscopy on crosslinked nanobodies tested on C-type lectin-like receptor 2 (CLEC-2) show different outcomes for divalent and tetravalent nanobody ligands on CLEC-2 clustering, also dependent on CLEC-2 expression levels.
Joanne C. Clark   +16 more
doaj   +1 more source

Computational and experimental prediction of human C-type lectin receptor druggability

open access: yesFrontiers in Immunology, 2014
Mammalian C-type lectin receptors are involved in many aspects of immune cell regulation such as pathogen recognition, clearance of apoptotic bodies and lymphocyte homing.
Jonas eAretz   +8 more
doaj   +1 more source

The Vi Capsular Polysaccharide of Salmonella Typhi Promotes Macrophage Phagocytosis by Binding the Human C-Type Lectin DC-SIGN

open access: yesmBio, 2022
Capsular polysaccharides are common virulence factors of extracellular, but not intracellular bacterial pathogens, due to the antiphagocytic properties of these surface structures.
Lillian F. Zhang   +8 more
doaj   +1 more source

The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure

open access: yesNature Communications, 2020
The molecular mechanisms that drive irreversible acute liver failure remain poorly characterized. Here, the authors show that the recently discovered platelet receptor CLEC-2 (C-type lectin-like receptor) perpetuates and worsens liver damage during acute
Abhishek Chauhan   +14 more
doaj   +1 more source

Characterization of the receptors for mycobacterial cord factor in Guinea pig. [PDF]

open access: yesPLoS ONE, 2014
Guinea pig is a widely used animal for research and development of tuberculosis vaccines, since its pathological disease process is similar to that present in humans.
Kenji Toyonaga   +2 more
doaj   +1 more source

DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling

open access: yesFrontiers in Immunology, 2023
Dendritic cell immunoreceptor (DCIR) is an inhibitory C-type lectin receptor that acts as a negative regulator in the immune system and bone metabolism.
Tomonori Kaifu   +5 more
doaj   +1 more source

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