Results 11 to 20 of about 168,647 (296)

Signalling through C-type lectin receptors: shaping immune responses [PDF]

Nature Reviews Immunology, 2009
C-type lectin receptors (CLRs) expressed by dendritic cells are crucial for tailoring immune responses to pathogens. Following pathogen binding, CLRs trigger distinct signalling pathways that induce the expression of specific cytokines which determine T cell polarization fates.
Sonja Gringhuis
exaly   +4 more sources

Lectin-like bacteriocins from pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor [PDF]

, 2014
Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display a genus-specific killing activity. Here we show that pyocin L1, a novel member of this family from Pseudomonas aeruginosa, targets susceptible strains of this species ...
A Hviid, A Molinaro, AC Graham, AD Vinion-Dubiel, AHA Parret, AHA Parret, AJ McCoy, Aleksander W. Roszak, AM Abdel-Mawgoud, AW Schuttelkopf, Brian Smith, C Kleanthous, C Manichanh, CL Brown, CL Ng, D Franke, D Walker, Daniel Walker, DI Svergun, E Cascales, E Kurimoto, EJM Van Damme, F Gorrec, F Long, G Gorkiewicz, G Hester, G Kurisu, GN Murshudov, GR Vasta, Guy Tran Van Nhieu, HL Rocchetta, Inokentijs Josts, J Henao-Mejia, J Qin, JAM Fyfe, JB Lyczak, Joel Milner, JS Lam, JU Scher, K Smith, K Zeth, Kai I. Waløen, KC Carroll, KH Caffall, L Holm, L Stewart, Laura C. McCaughey, M Ramm, M Rivera, M Shimokawa, M-F Incardona, MA Jacobs, MB Kozin, ME Spehlmann, MGK Ghequire, MGK Ghequire, MGK Ghequire, MJ Claesson, N Sharon, Nicholas P. Tucker, NR Chandra, Olwyn Byron, P Emsley, PD Adams, PV Konarev, R Grinter, R Grinter, RA Laskowski, Rhys Grinter, Richard J. Cogdell, S Mori, Sharon Kelly, SY Shaw, T Ogawa, Tom Evans, V Ovod, VB Chen, VV Ovod, VV Volkov, WF Vranken, Y Hao, Y Michel-Briand, YA Knirel   +82 more
core   +12 more sources

BACL is a novel brain-associated, non-NKC-encoded mammalian C-type lectin-like receptor of the CLEC2 family [PDF]

, 2013
Natural Killer Gene Complex (NKC)–encoded C-type lectin-like receptors (CTLRs) are expressed on various immune cells including T cells, NK cells and myeloid cells and thereby contribute to the orchestration of cellular immune responses.
Lysenko, Olga, Mittelbronn, Michel Guy André, Schulte, Dorothea, Steinle, Alexander   +3 more
core   +13 more sources

C-Type Lectin Receptors in Asthma [PDF]

Frontiers in Immunology, 2018
Asthma is a heterogeneous disease that affects approximately 300 million people worldwide, largely in developed countries. The etiology of the disease is poorly understood, but is likely to involve specific innate and adaptive responses to inhaled microbial components that are found in allergens.
Sabelo Hadebe, Sabelo Hadebe, Frank Brombacher, Frank Brombacher, Gordon D. Brown, Gordon D. Brown   +5 more
openaire   +4 more sources

C-type lectin receptors orchestrate antifungal immunity [PDF]

Nature Immunology, 2012
Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family.
Sarah E, Hardison, Gordon D, Brown
openaire   +2 more sources

Lectin ligands: New insights into their conformations and their dynamic behavior and the discovery of conformer selection by lectins [PDF]

, 1998
The mysteries of the functions of complex glycoconjugates have enthralled scientists over decades. Theoretical considerations have ascribed an enormous capacity to store information to oligosaccharides, In the interplay with lectins sugar-code words of ...
Bovin, N. V., Burchert, M., Frank, M., Gabius, Hans-Joachim, Gilleron, M., Kaltner, Herbert, Kayser, G., Kozár, T., Lieth, Claus-Wilhelm von der, Siebert, H. C., Tajkhorshid, Emad, Vliegenthart, JFG   +11 more
core   +10 more sources

De novo assembly of transcriptomes from a B73 maize line introgressed with a QTL for resistance to gray leaf spot disease reveals a candidate allele of a lectin receptor-like kinase [PDF]

, 2020
Gray leaf spot (GLS) disease in maize, caused by the fungus Cercospora zeina, is a threat to maize production globally. Understanding the molecular basis for quantitative resistance to GLS is therefore important for food security.
Berger, Dave K., Pierneef, Rian, Scheepers, Kevin Daniel, Sterck, Lieven, Swart, Velushka, Van de Peer, Yves, Welgemoed, Tanya   +6 more
core   +2 more sources

C-type Lectin Receptors for Tumor Eradication: Future Directions [PDF]

Cancers, 2011
Dendritic cells are key regulators in directing immune responses and therefore are under extensive research for the induction of anti-tumor responses. DCs express a large array of receptors by which they scan their surroundings for recognition and uptake of pathogens.
Streng-Ouwehand, Ingeborg, Unger, Wendy W J, Van Kooyk, Yvette   +2 more
openaire   +4 more sources

Targeting C-Type Lectin Receptors for Cancer Immunity [PDF]

Frontiers in Immunology, 2015
C-type lectin receptors (CLRs) are a large family of soluble and trans-membrane pattern recognition receptors that are widely and primarily expressed on myeloid cells. CLRs are important for cell-cell communication and host defense against pathogens through the recognition of specific carbohydrate structures. Similar to a family of Toll-like receptors,
Huimin eYan, Huimin eYan, Tomomori eKamiya, Tomomori eKamiya, Papawee eSuabjakyong, Papawee eSuabjakyong, Noriko M Tsuji   +6 more
openaire   +3 more sources

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei [PDF]

, 2020
BACKGROUND Vacuolar H-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles.
Hide, G, Lai, D-H, Li, F-J, Lun, Z-R, Xu, Z-S   +4 more
core   +2 more sources