Results 201 to 210 of about 30,240 (256)

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Latent Neoehrlichia mikurensis Infections May Be Reactivated in Patients With B‐Cell Lymphomas Treated With Rituximab

Immunology, EarlyView.
Eight percent of this cohort of patients had a latent Neoehrlichia mikurensis infection. It was only the latently infected patients who had N. mikurensis‐specific T cells, not the matched B‐cell lymphoma patients without the infection. The T‐cell responses of latently infected patients included perforin‐expressing Th1 and CD8+ T cells that upregulated ...
Linda Wass, Catharina Lewerin, Daniel Jaén‐Luchoro, Christine Lingblom, Christine Wennerås   +4 more
wiley   +1 more source

Blood Immunopathology of Tuberculosis Patients Disrupts Monocyte‐Dependent T‐Cell Activation and Cytokine Expression

Immunology, EarlyView.
TB serum selectively disrupts monocyte‐dependent PHA T cell activation and cytokines associated with proliferation while preserving SEB T cell and Pam3/PHA monocyte cytokine responses. ABSTRACT Pulmonary tuberculosis in humans is characterised by features of immunopathology, which influence both antimycobacterial therapy and the long‐term prognosis. In
Joseph F. Arthur, Hubert S. Ahor, Monika M. Vivekanandan, Difery Minadzi, Augustine Yeboah, Millicent Lamptey, Victoria A. Ofori, Albert D. Kegya, Rejoice Arthur, Linda A. Amoakoa, Ernest Adankwah, Dorcas O. Owusu, Mohammed K. Abass, Fredrick Gyamfi Apraku, Nana K. Ayisi‐Boateng, Seth Adane, Salisu Zakaria, Ertan Mayatepek, Julia Seyfarth, Richard O. Phillips, Marc Jacobsen   +20 more
wiley   +1 more source

The receptor‐like pseudokinase LENG stimulates chilling tolerance in rice by inhibiting the activity of the OsCRPK1‐OsGF14d module

Journal of Integrative Plant Biology, EarlyView.
The rice receptor‐like pseudokinase LENG enhances chilling tolerance by binding to and suppressing the kinase activity of OsCRPK1, thereby preventing OsCRPK1‐mediated phosphorylation of the cold‐tolerance positive regulator OsGF14d. ABSTRACT Cold damage during the seedling and reproductive stages has a pronounced impact on rice development and yield ...
Shuting Yuan, Chunjue Xu, Xia Wang, Wei Yan, Xiaojie Hua, Yi Zhuang, Cuifang Wang, Changjian Wang, Yihang Gong, Jianxin Wu, Letian Chen, Xiaoyan Tang, Wenbo Pan   +12 more
wiley   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

Alternative Protein Sources in Poultry and Pig Nutrition—A Review

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Proteins are an essential nutrient for the viability of all animals, enabling organisms to grow, regenerate and defend themselves against pathogenic organisms. Soybean and soybean‐based materials are commonly used to supplement protein in animal nutrition.
Lukáš Čumplík, Dana Zálešáková, Jakub Novotný, Lenka Kudlová, Leoš Pavlata, Ondřej Šťastník   +5 more
wiley   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source