Results 231 to 240 of about 38,660 (297)
Small Structures, EarlyView.Galectin‐10 crystals prepared by cell‐free protein crystallization serve as the scaffold to capture the saccharides to determine the atomic‐resolution structure of a trisaccharide bound to protein. Molecular dynamics simulation combined with the mutation of scaffold crystals offers insights into how the binding site architecture modulates saccharide ...
Mariko Kojima +7 more
wiley +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Cadmium (Cd), a heavy metal, disrupts the structure of seminiferous tubules and induces cell death at multiple stages of sperm development. Cd also impairs Leydig cells (LCs), resulting in reduced serum testosterone (T) levels. This study primarily examined the impact of Cd on the mitochondrial compartment and mitochondrial‐associated ...
Debora Latino +7 more
wiley +1 more source
Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL. [PDF]
Proc Natl Acad Sci U S A, 2013 Furukawa A +10 more
europepmc +1 more source
The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li +4 more
wiley +1 more source
Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang +3 more
wiley +1 more source
Decoding the Genome of the Komagataella phaffii Type Strain CBS 2612
Yeast, EarlyView.Visualization of annotated features in the genome of the Komagataella phaffii type strain CBS 2612 including four SNPs and centromere positions. Comparison of the number of coding sequences, tRNAs and rRNAs to other closely related K. phaffii strains.
Nadine Elpida Tatto +6 more
wiley +1 more source
Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma
Allergy, EarlyView.Complement activation module, particularly C5, is positively associated with eosinophilic inflammation in severe asthma cohorts. Elevated C5 expression correlates with poor lung function improvement and persistent eosinophilic inflammation. Mouse model studies confirm that C5 exacerbates eosinophilic inflammation, highlighting its potential as a ...
Cong Dong +217 more
wiley +1 more source