Results 241 to 250 of about 39,289 (292)

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Characterization of a Novel <i>Galactia lindenii</i> Lectin and Its Effects on Lepidopteran Midgut Cells. [PDF]

Int J Mol Sci
Casas-Corredor Z, Reyes-Montaño E, Vega-Castro N, Quintero M, Hidalgo-Roa D, Fernández-Alonso JL.   +5 more
europepmc   +1 more source

Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflammation via the Dectin1/Syk/CARD9/IRF5/NF‐κB pathway

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Inflammation plays an essential role in the pathogenesis of diabetic nephropathy (DN). Linderalactone (LNL), as a natural sesquiterpene lactone, has been discovered to have anti‐inflammatory activation. However, the effects of linderalactone on diabetes‐associated renal damage remain unclear.
Hao Chen, Sheng Xu, Bingrong Chen, Xishan Xiong, Jinrui Hu, Yuhong Wu, Tianrui Wang, Huishang Wang   +7 more
wiley   +1 more source

Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Hair follicles (HFs) were extracted from skin biopsies. From these, original sequencing data were obtained and integrated with two independent studies to build a HF single‐cell transcriptomic atlas. It enabled delineating the fate of HF stem cells.
Audrey Onfroy, Francette Jean‐Louis, Philippe Le Corvoisier, Fanny Coulpier, Kévin Muret, Eric Bonnet, Raphaele Arrouasse, Caroline Boucle, Salwa Abid, Emilie Sbidian, Christina Bergqvist, Pierre Wolkenstein, Véronique Godot, Jean‐François Deleuze, Yves Lévy, Piotr Topilko, Etienne Audureau, Sophie Hue   +17 more
wiley   +1 more source

Targeting Yeast Pathogens with Lectins: A Narrative Review from Mechanistic Insights to the Need for Addressing Translational Challenges. [PDF]

Biomedicines
Ferreira GRS, Lira TLDS, Napoleão TH.
europepmc   +1 more source

Enzymatic tailoring of anionic glycans for characterizing lectin and antibody specificities in a microarray format. [PDF]

J Biol Chem
Nuschy L, Wilson IBH.
europepmc   +1 more source

Identification of aberrant α-2,3 sialylation of cartilage associated with osteonecrosis of the femoral head based on integrated multi-omics analyses. [PDF]

BBA Adv
Lu X, Wang X, Xiong M, Wang P, Zhu Y, Wang X, Liu X, Yu H, Liu R.   +8 more
europepmc   +1 more source

Editor's Choice Protein engineering strategies to develop lectins by design. [PDF]

Glycobiology
Hombu R, Beatty LE, Neelamegham S.
europepmc   +1 more source

Assessment of Genotoxicity and Cytotoxicity of Tepary Bean (<i>Phaseolus acutifolius</i>) Seed Protein Extract. [PDF]

Life (Basel)
Valadez-Vega C, Ortigoza-Fonseca L, Betanzos-Cabrera G, Velasco-Azorsa R, Muñoz-Pérez VM, Morales-González JA, Velázquez-Morales BP, Bernardino-Nicanor A, González-Cruz L, Estrada-Luna D, Lugo-Magaña O.   +10 more
europepmc   +1 more source