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C-type lectins in immunity and homeostasis
Nature Reviews Immunology, 2018 The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands and that regulate a diverse range of physiological functions. Most research attention has focused on the ability of C-type lectins to function in innate and adaptive antimicrobial immune responses, but these proteins are increasingly being recognized to have a
Gordon D Brown, Janet A Willment
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Current Opinion in Structural Biology, 2020
C-type lectins are the largest and most diverse family of mammalian carbohydrate-binding proteins. They share a common protein fold, which provides the unifying basis for calcium-mediated carbohydrate recognition. Their involvement in a multitude of biological functions is remarkable.
Christoph Rademacher +2 more
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C-type lectins are the largest and most diverse family of mammalian carbohydrate-binding proteins. They share a common protein fold, which provides the unifying basis for calcium-mediated carbohydrate recognition. Their involvement in a multitude of biological functions is remarkable.
Christoph Rademacher +2 more
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Myeloid C-type lectins in innate immunity
Nature Immunology, 2006C-type lectins expressed on myeloid cells comprise a family of proteins that share a common structural motif, and some act as receptors in pathogen recognition. But just as the presence of leucine-rich repeats alone is not sufficient to define a Toll-like receptor, the characterization of C-type lectin receptors in innate immunity requires the ...
David Sancho +2 more
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, 2014 C-type lectins belong to a superfamily of receptors that share structural homology in their carbohydrate recognition domains and often bind to carbohydrates in a Ca-dependent fashion. Whereas endocytic C-type lectin receptors (CLRs) trigger the receptor-mediated endocytosis of soluble ligands, myeloid CLRs in innate immunity act as pattern recognition ...
Stephanie Zimmermann +3 more
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C-Type Lectin Receptors in Phagocytosis
2020C-type lectin receptors (CLRs) are a family of transmembrane proteins having at least one C-type lectin-like domain (CTLD) on the cell surface and either a short intracellular signaling tail or a transmembrane domain that facilitates interaction with a second protein, often the Fc receptor common gamma chain (FcRγ), that mediates signaling.
Kai Li, David M. Underhill
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Genomic analysis of C-type lectins
Biochemical Society Symposia, 2002Many biological effects of complex carbohydrates are mediated by lectins that contain discrete carbohydrate-recognition domains. At least seven structurally distinct families of carbohydrate-recognition domains are found in lectins that are involved in intracellular trafficking, cell adhesion, cell–cell signalling, glycoprotein turnover and innate ...
Andrew J. Fadden, Kurt Drickamer
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C-type Lectins in Immunity to Lung Pathogens
2020The respiratory tract is tasked with responding to a constant and vast influx of foreign agents. It acts as an important first line of defense in the innate immune system and as such plays a crucial role in preventing the entry of invading pathogens.
Raymond, Benjamin +2 more
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2012
Historically the C-Type lectins (CLEC) or C-type lectin receptors (CLR) form a family of Ca2+ dependent carbohydrate binding proteins which have a common sequence motif of 115–130 amino acid residues, referred to as the carbohydrate recognition domain (CRD). The C-type designation is from their requirement for calcium for binding.
Anita Gupta, G. S. Gupta
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Historically the C-Type lectins (CLEC) or C-type lectin receptors (CLR) form a family of Ca2+ dependent carbohydrate binding proteins which have a common sequence motif of 115–130 amino acid residues, referred to as the carbohydrate recognition domain (CRD). The C-type designation is from their requirement for calcium for binding.
Anita Gupta, G. S. Gupta
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Insect C-Type Lectins in Microbial Infections
2020C-type lectins (CTLs) are a family of carbohydrate-recognition domain (CRD)-containing proteins that bind to ligands in a calcium-dependent manner. CTLs act as important components of insect innate immune responses, such as pattern recognition, agglutination, encapsulation, melanization, phagocytosis and prophenoloxidase activation, as well as gut ...
Gong Cheng, Yibin Zhu, Xi Yu
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C-type lectin receptors in antifungal immunity
Trends in Microbiology, 2008Fungal infections represent a significant health burden, especially in immunocompromised individuals, yet many of the underlying immunological mechanisms involved in the recognition and control of these pathogens are unclear. The identification of the Toll-like receptors (TLRs) has shed new insights on innate microbial recognition and the initiation of
Gordon D. Brown, Janet A. Willment
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