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Current Opinion in Structural Biology, 1999
Carbohydrate-recognition domains of C-type (Ca2+-dependent) animal lectins serve as prototypes for an important family of protein modules. Only some domains in this family bind Ca2+ or sugars. A comparison of recent structures of C-type lectin-like domains reveals diversity in the modular fold, particularly in the region associated with Ca2+ and sugar ...
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Carbohydrate-recognition domains of C-type (Ca2+-dependent) animal lectins serve as prototypes for an important family of protein modules. Only some domains in this family bind Ca2+ or sugars. A comparison of recent structures of C-type lectin-like domains reveals diversity in the modular fold, particularly in the region associated with Ca2+ and sugar ...
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The C‐type lectin superfamily in the immune system
Immunological Reviews, 1998Summary: Protein‐carbohydrate interactions serve multiple functions in the immune system. Many animal lectins (sugar‐binding proteins) mediate both pathogen recognition and cell‐cell interactions using structurally related Ca2+‐dependent carbohydrate‐recognition domains (C‐type CRDs).
Maureen E. Taylor +2 more
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C-Type Lectin Receptors in Antifungal Immunity
2020Most fungal species are harmless to humans and some exist as commensals on mucocutaneous surfaces. Yet many fungi are opportunistic pathogens, causing life-threatening invasive infections when the immune system becomes compromised. The fungal cell wall contains conserved pathogen-associated molecular patterns (PAMPs), which allow the immune system to ...
Christina Nikolakopoulou +4 more
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Insect C-type lectins in innate immunity
Developmental & Comparative Immunology, 2018C-type lectins (CTLs) are a family of proteins that contain characteristic modules of carbohydrate-recognition domains (CRDs) and they possess the binding activity to ligands in a calcium-dependent manner. CTLs play important roles in animal immune responses, and in insects, they are involved in opsonization, nodule formation, agglutination ...
Xiaofeng Xia +3 more
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Role of C-Type Lectins in Mycobacterial Infections
Current Drug Targets, 2008Worldwide clinical cases due to multi drug- and extensively drug-resistant strains of Mycobacterium tuberculosis (M.tb) are increasing making the need for new therapies more critical than ever. A major obstacle for designing new drugs to treat mycobacterial infections is our limited knowledge of the interface between the bacillus (especially M.tb) and ...
Jordi B. Torrelles +4 more
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C-Type Lectin Family: Overview [PDF]
, 2014 Members of the C-type lectin family of glycan-binding receptors in animals contain modular carbohydrate recognition domains (CRDs) that form a subset of a larger structural class of protein modules designated C-type lectin-like domains. Two broad categories of C-type CRDs bind either mannose and related sugars or galactose and related sugars at the Ca ...
Maureen E. Taylor, Kurt Drickamer
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Emerging Groups of C-Type Lectins [PDF]
, 2012 Layilin, a ~55-kDa lectin, is a widely expressed integral membrane hyaluronan receptor, originally identified as a binding partner of talin located in membrane ruffles. It is recruited to membrane ruffles in cells induced to migrate in in vitro wounding experiments and in peripheral ruffles in spreading cells.
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A Family of C-Type Lectins in Manduca sexta
2001Insects have a rapid and effective immune system against microbial infections (Gillespie et al., 1997) that shares common characteristics with the innate immune system of vertebrates. It also consists of humoral and cellular responses. In the cellular responses such as phagocytosis, nodule formation and encapsulation, hemocytes play important roles. In
Xiao-Qiang Yu, Michael R. Kanost
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Glycomimetics for the inhibition and modulation of lectins
Chemical Society Reviews, 2023, Petra Menova, Elena Shanina
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Multivalent glycosystems for human lectins
Chemical Society Reviews, 2023Macarena Martínez-Bailén +2 more
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