Results 41 to 50 of about 18,702,394 (209)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

open access: yesAngewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma   +5 more
wiley   +2 more sources

Identification of QTLs Associated with Virulence Related Traits and Drug Resistance in Cryptococcus neoformans

open access: yesG3: Genes, Genomes, Genetics, 2016
Cryptococcus neoformans is a basidiomycete fungus capable of causing deadly meningoenchephilitis, primarily in immunocompromised individuals. Formerly, C. neoformans was composed of two divergent lineages, but these have recently been elevated to species
Aaron A. Vogan   +3 more
doaj   +1 more source

Cryptococcus neoformans isolation from swallow (Hirundo rustica) excreta in Iran

open access: yesRevista do Instituto de Medicina Tropical de São Paulo, 2011
Cryptococcus neoformans is an encapsulated yeast that can cause cryptococcosis, a life-threatening infection that mainly occurs in immunocompromised patients. The major environmental sources of C.
Mohammad T. Hedayati   +4 more
doaj   +1 more source

Macropinocytosis as a potential mechanism driving neurotropism of Cryptococcus neoformans

open access: yesFrontiers in Cellular and Infection Microbiology, 2023
Cryptococcus neoformans can invade the central nervous system by crossing the blood-brain barrier via a transcellular mechanism that relies on multiple host factors. In this narrative, we review the evidence that a direct interplay between C.
Dylan M. Lanser   +3 more
doaj   +1 more source

Conserved Autophagy Pathway Contributes to Stress Tolerance and Virulence and Differentially Controls Autophagic Flux Upon Nutrient Starvation in Cryptococcus neoformans

open access: yesFrontiers in Microbiology, 2019
Autophagy is mainly a catabolic process, which is used to cope with nutrient deficiency and various stress conditions. Human environment often imposes various stresses on Cryptococcus neoformans, a major fungal pathogen of immunocompromised individuals ...
Xueru Zhao   +7 more
doaj   +1 more source

Cryptococcus neoformans modulates extracellular killing by neutrophils

open access: yesFrontiers in Microbiology, 2011
We recently established a key role for host sphingomyelin synthase (SMS) in the regulation of the killing activity of neutrophils against Cryptococcus neoformans. In this work, we studied the effect of C. neoformans on the killing activity of neutrophils
Asfia eQureshi   +4 more
doaj   +1 more source

Amoeba resistance varies between strains of C. neoformans.

open access: yes, 2023
A. A schematic overview of the amoeba resistance assay. A lawn of Cryptococcus is grown on V8 media for 60 hours. A. castellanii are added to the center of the lawn. A.
Sheng Sun (142836)   +8 more
core   +1 more source

Nonlytic exocytosis of Cryptococcus neoformans from neutrophils in the brain vasculature

open access: yesCell Communication and Signaling, 2019
Background Cryptococcus neoformans (C. neoformans) is an encapsulated budding yeast that causes life-threatening meningoencephalitis in immunocompromised individuals, especially those with acquired immunodeficiency syndrome (AIDS).
Xiaofan Yang   +4 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

open access: yesAdvanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li   +7 more
wiley   +1 more source

Variabilidade genética de Cryptococcus neoformans isolado de pacientes HIV positivos atendidos no Hospital Nereu Ramos de Florianópolis, Santa Catarina: (dissertação) [PDF]

open access: yes, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-graduação em BiotecnologiaA criptococose é uma infecção fúngica de distribuição mundial causada pela levedura encapsulada Cryptococcus ...
Dambrós, Bibiana Paula
core  

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