Pregnant sows immunized with Cryptosporidium parvum significantly reduced infection in newborn piglets challenged with C. parvum but not with C. hominis. [PDF]
PLoS Neglected Tropical Diseases, 2022 BackgroundThe piglet is the only model to investigate the immunogenic relationship between Cryptosporidium hominis and C. parvum, the species responsible for diarrhea in humans.
Abhineet Sheoran +7 more
doaj +4 more sources
Metabolic Signatures of Cryptosporidium parvum-Infected HCT-8 Cells and Impact of Selected Metabolic Inhibitors on C. parvum Infection under Physioxia and Hyperoxia [PDF]
Biology, 2021 Cryptosporidium parvum is an apicomplexan zoonotic parasite recognized as the second leading-cause of diarrhoea-induced mortality in children. In contrast to other apicomplexans, C.parvum has minimalistic metabolic capacities which are almost exclusively
Juan Vélez +8 more
doaj +2 more sources
Cryptosporidium Species and C. parvum Subtypes in Farmed Bamboo Rats. [PDF]
Pathogens, 2020 Bamboo rats (Rhizomys sinensis) are widely farmed in Guangdong, China, but the distribution and public health potential of Cryptosporidium spp. in them are unclear. In this study, 724 fecal specimens were collected from bamboo rats in Guangdong Province and analyzed for Cryptosporidium spp. using PCR and sequence analyses of the small subunit rRNA gene.
Li F +6 more
europepmc +5 more sources
Novel lactate dehydrogenase inhibitors with in vivo efficacy against Cryptosporidium parvum
PLoS Pathogens, 2019 Cryptosporidium parvum is a highly prevalent zoonotic and anthroponotic protozoan parasite that causes a diarrheal syndrome in children and neonatal livestock, culminating in growth retardation and mortalities. Despite the high prevalence of C.
Kun Li, Sara M Nader, Xuejin Zhang
exaly +2 more sources
Cryptosporidium species and subtypes in Norway: predominance of C. parvum and emergence of C. mortiferum. [PDF]
Emerg Microbes InfectPCR-based diagnostics has revealed the previously largely unknown Cryptosporidium transmission and infections in high-income countries. This study aimed to determine domestic and imported subtypes of Cryptosporidium species in Norway, evaluate their demographic distribution, and identify potential small outbreaks.
Tipu JH +12 more
europepmc +8 more sources
Veterinary Research, 2023 Cryptosporidium spp. remain a major cause of waterborne diarrhea and illness in developing countries and represent a significant burden to farmers worldwide.
Karim Tarik Adjou +10 more
doaj +1 more source
Parasites & Vectors, 2022 Background MicroRNAs (miRNAs) are involved in the regulation of both the innate and adaptive immune response to Cryptosporidium parvum infection. We previously reported that C.
Fujie Xie +11 more
doaj +1 more source
In Vitro Susceptibility of Cryptosporidium parvum to Plant Antiparasitic Compounds
Pathogens, 2022 Cryptosporidium parvum is a significant cause of watery diarrhoea in humans and other animals worldwide. Although hundreds of novel drugs have been evaluated, no effective specific chemotherapeutic intervention for C. parvum has been reported.
Sandamalie Ranasinghe +4 more
doaj +1 more source
Mechanisms of C. parvum-induced coagulopathy in mice [PDF]
British Journal of Cancer, 1980 I.v. injection of Corynebacterium parvum (CP) into C57BL and BALB/c mice caused profound coagulation changes, featuring thrombocytopenia, decreased fibrinogen, increased fibrin/fibrinogen degradation products, and a concomitant microangiopathic haemolytic anaemia. These changes were greatest on the 9th day after CP, with recovery by Day 21.
Mitcheson, H D +3 more
openaire +2 more sources
NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses. [PDF]
PLoS Pathogens, 2009 Cryptosporidium parvum is a protozoan parasite that infects the gastrointestinal epithelium and causes diarrheal disease worldwide. Innate epithelial immune responses are key mediators of the host's defense to C. parvum.
Rui Zhou +5 more
doaj +1 more source