Metabolic Signatures of Cryptosporidium parvum-Infected HCT-8 Cells and Impact of Selected Metabolic Inhibitors on C. parvum Infection under Physioxia and Hyperoxia [PDF]
Biology, 2021 Cryptosporidium parvum is an apicomplexan zoonotic parasite recognized as the second leading-cause of diarrhoea-induced mortality in children. In contrast to other apicomplexans, C.parvum has minimalistic metabolic capacities which are almost exclusively
Juan Vélez +8 more
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Pregnant sows immunized with Cryptosporidium parvum significantly reduced infection in newborn piglets challenged with C. parvum but not with C. hominis. [PDF]
PLoS Neglected Tropical Diseases, 2022 BackgroundThe piglet is the only model to investigate the immunogenic relationship between Cryptosporidium hominis and C. parvum, the species responsible for diarrhea in humans.
Abhineet Sheoran +7 more
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Immunological mechanisms in metastatic spread and the antimetastatic effects of C. parvum [PDF]
British Journal of Cancer, 1977 The effects of the host's immune response on metastatic spread was investigated by observing the numbers of pulmonary metastases that developed from an s.c. implant of the Lewis lung carcinoma in C57BL mice in which different cell populations had been suppressed. Macrophage function was impaired by treatment with silica (Si), cortisone acetate (CA), or
P D, Jones, J E, Castro
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Effect of C. Parvum on immunization with irradiated tumour cells [PDF]
British Journal of Cancer, 1976 S.c. injection of tumour cells or small pieces of tumour irradiated to a dose of 22,000 rad evoked resistance to live challenge with the same tumour (a CBA strain fibrosarcoma induced with methylcholanthrene) 14 days later. This resistance was, however, over-ridden if the challenging inoculum was sufficiently large, and did not develop if the cells ...
Woodruff, M F +3 more
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NF-kappaB p65-Dependent Transactivation of miRNA Genes following Cryptosporidium parvum Infection Stimulates Epithelial Cell Immune Responses [PDF]
PLoS Pathogens, 2009 Cryptosporidium parvum is a protozoan parasite that infects the gastrointestinal epithelium and causes diarrheal disease worldwide. Innate epithelial immune responses are key mediators of the host's defense to C. parvum.
Rui Zhou, Xian-Ming Chen, Guoku Hu
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Cryptosporidium Species and C. parvum Subtypes in Farmed Bamboo Rats. [PDF]
Pathogens, 2020 Bamboo rats (Rhizomys sinensis) are widely farmed in Guangdong, China, but the distribution and public health potential of Cryptosporidium spp. in them are unclear. In this study, 724 fecal specimens were collected from bamboo rats in Guangdong Province and analyzed for Cryptosporidium spp. using PCR and sequence analyses of the small subunit rRNA gene.
Li F +6 more
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Abrogation of the anti-metastatic activity of C. parvum by antilymphocyte serum [PDF]
British Journal of Cancer, 1976 Corynebacterium parvum (C. parvum) can cause a significant reduction in the growth of both primary tumours and their metastases (Sadler and Castro, 1976; Proctor, Rudenstam and Alexander, 1973; Woodruff and Boak, 1966). When consideration is given to the
Sadler, T E, Castro, J E
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PCR-RFLP analysis of the Cryptosporidium oocyst wall protein (COWP) gene discriminates between C. wrairi and C. parvum, and between C. parvum isolates of human and animal origin [PDF]
FEMS Microbiology Letters, 2006 Cryptosporidium wrairi was isolated from guinea pigs during a spontaneous outbreak of cryptosporidiosis. Despite the morphological and antigenic similarities to C. parvum, C. wrairi displayed a different host range and site of infection and may represent a separate species or sub-species.
SPANO F +4 more
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Novel lactate dehydrogenase inhibitors with in vivo efficacy against Cryptosporidium parvum
PLoS Pathogens, 2019 Cryptosporidium parvum is a highly prevalent zoonotic and anthroponotic protozoan parasite that causes a diarrheal syndrome in children and neonatal livestock, culminating in growth retardation and mortalities. Despite the high prevalence of C.
Benjamin Ray, Kun Li, William H Witola
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C. parvum gets the CRISPR upgrade [PDF]
Nature Reviews Genetics, 2015 Elizabeth Zuccala
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