Results 291 to 300 of about 3,095,271 (376)

52 Evidence for Ca++ dependent. non-covalent C1s-C1 inhibitor complexes in normal human serum

, 1988
Kenneth P. Mathews, Satoru Sugimoto, Bruce L. Zuraw   +2 more
openalex   +1 more source

A Mini‐Spidroin Forms High‐Performance Artificial Spider Silk via Edge‐Cysteine–Locked β‐Sheet Assembly

Advanced Science, EarlyView.
Cysteine‐engineered mini‐spidroins (∼33 kDa) undergo phosphate‐induced liquid–liquid phase separation (LLPS), where disulfide bonds lock partially aligned polyA segments. Subsequent microfluidic spinning promotes directional β‐sheet crystallization, producing fibers with 531 MPa strength and 182 MJ/m3 toughness.
Min Li, Huan Chen, Qi Zhang, Xiaoyun Xu, Yini Zheng, Chunyu Lyu, Weibin Jia, Jun Fan, Fu‐Rong Chen, Wei Liu, Jinlian Hu   +10 more
wiley   +1 more source

Hereditary angioedema with normal C1 inhibitor associated with carboxypeptidase N deficiency. [PDF]

J Allergy Clin Immunol Glob
Vincent D, Parsopoulou F, Martin L, Gaboriaud C, Demongeot J, Loules G, Fischer S, Cichon S, Germenis AE, Ghannam A, Drouet C.   +10 more
europepmc   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Screening for type II hereditary angioedema-the "poor man's c1-inhibitor function". [PDF]

J Allergy Clin Immunol Glob
Jindal AK, Chiang V, Barman P, Sil A, Chawla S, Au EYL, Rawat A, Li PH.   +7 more
europepmc   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Real-world outcomes of patients with hereditary angioedema with normal C1-inhibitor function and patients with idiopathic angioedema of unknown etiology in Canada. [PDF]

Allergy Asthma Clin Immunol
Adatia A, Boursiquot JN, Goodyear D, Kalicinsky C, Kanani A, Waserman S, Nguyen MML, Wadhwa A, Weiss J, El-Zoeiby A, Betschel S.   +10 more
europepmc   +1 more source

Free‐Volume Regulation Enables Significantly Enhanced Electrical Breakdown via Short‐Chain Molecular Spatial‐Positioning Intercalation into Poly(vinylidene fluoride)

Advanced Science, EarlyView.
An innovative molecular spatial‐positioning shimming strategy is developed to optimize the electrical properties of poly(vinylidene fluoride) (PVDF). By intercalating polyethylene wax (PE wax) short‐chain molecules into PVDF's free volume, the film achieves a significantly enhanced energy density of 32.67 J cm−3.
Ziyue Wang, Jiyang Xie, Wanbiao Hu
wiley   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

A real-world study of hereditary angioedema patients due to C1 inhibitor deficiency treated with danazol in the Brazilian Public Health System. [PDF]

Front Med (Lausanne)
Ritter AMV, Silva S, de Paula R, Senra J, Carvalho F, Ribeiro T, Valle SOR.   +6 more
europepmc   +1 more source