Results 1 to 10 of about 4,257,255 (225)

Fibulin-1C, C1 Esterase Inhibitor and Glucose Regulated Protein 75 Interact with the CREC Proteins, Calumenin and Reticulocalbin. [PDF]

PLoS ONE, 2015
Affinity purification, immunoprecipitation, gel electrophoresis and mass spectrometry were used to identify fibulin-1C, C1 esterase inhibitor and glucose regulated protein 75, grp75, as binding partners of the CREC proteins, calumenin and reticulocalbin.
Gry Aune Westergaard Hansen, Maja Ludvigsen, Christian Jacobsen, Claudia Cangemi, Lars Melholt Rasmussen, Henrik Vorum, Bent Honoré   +6 more
doaj   +1 more source

Treatment of hereditary angioedema—single or multiple pathways to the rescue

Frontiers in Allergy, 2022
Hereditary angioedema (HAE) is a rare disease caused by mutations in the SERPING1 gene. This results in deficient or dysfunctional C1 esterase inhibitor (C1-INH) and affects multiple proteases involved in the complement, contact-system, coagulation, and ...
Anna Valerieva, Hilary J. Longhurst
doaj   +1 more source

Effects of freezer storage time on levels of complement biomarkers

BMC Research Notes, 2017
Background There is uncertainty regarding how stable complement analytes are during long-term storage at – 80 °C. As part of our work program we have measured 17 complement biomarkers (C1q, C1 inhibitor, C3, C3a, iC3b, C4, C5, C9, FB, FD, FH, FI, TCC, Bb,
Angharad R. Morgan, Caroline O’Hagan, Samuel Touchard, Simon Lovestone, B. Paul Morgan   +4 more
doaj   +1 more source

Increased plasma concentrations of complement modulating proteins (C1 inhibitor, C4-binding protein, factor H and factor I) in psoriasis.

The Tohoku Journal of Experimental Medicine, 1988
By using single radial immunodiffusion we measured the plasma levels of four complement modulating proteins, i.e., C1 inhibitor, C4-binding protein, factor H and factor I in 19 psoriatic patients in comparison with those of healthy controls. Except for C1 inhibitor which was only marginally elevated, they were found to be significantly increased in ...
OHKOHCHI, KYOKO, TORINUKI, WAKIO, TAGAMI, HACHIRO   +2 more
openaire   +3 more sources

A Case of Angioedema Associated with Decreased C1 Inhibitor Activity

Allergology International, 2007
Background: We report a case of a 31-year-old woman who began to notice swelling of her arms at age 20. She was once given a diagnosis of cellulitis, but her symptoms spontaneously resolved.
Chizuko Yano, Arihito Ota, Hidemi Nakagawa   +2 more
doaj   +1 more source

Endothelial Cells Cultured from Human Brain Microvessels Produce Complement Proteins Factor H, Factor B, C1 Inhibitor, and C4

Immunobiology, 1998
The inflammatory mediators, cytokines and complement proteins are believed to regulate the sequential events during the development of lesions secondary to ischaemia and reperfusion. The endothelial cell monolayer of the brain microvasculature is the critical interface between the blood-borne mediators and brain tissue.
M, Vastag, J, Skopál, J, Kramer, K, Kolev, Z, Vokó, E, Csonka, R, Machovich, Z, Nagy   +7 more
openaire   +2 more sources

Biochemical and Functional Characterization of Plasma Derived Human Celestrase 1

Plasmatology
Background C1-esterase inhibitor (C1-INH) is a protein derived from fresh frozen human plasma and is widely used in the treatment of Hereditary Angioedema. C1-INH product must have high purity with preserved functionality.
Sheetal Dolia PhD, Sachin Verma MSc, Suma Ray PhD   +2 more
doaj   +1 more source

Managing Diagnosis, Treatment, and Burden of Disease in Hereditary Angioedema Patients with Normal C1-Esterase Inhibitor

Journal of Asthma and Allergy, 2023
Douglas Jones,1 Heidi Zafra,2 John Anderson3 1Rocky Mountain Allergy, Tanner Clinic, Layton, UT, USA; 2Division of Allergy and Clinical Immunology, Medical College of Wisconsin, Milwaukee, WI, USA; 3AllerVie Health, Birmingham, AL, USACorrespondence ...
Jones D, Zafra H, Anderson J
doaj  

Cytokines Associated with Amyloid Plaques in Alzheimer's Disease Brain Stimulate Human Glial and Neuronal Cell Cultures to Secrete Early Complement Proteins, But Not C1-Inhibitor

Experimental Neurology, 1999
Complement activation products C1q, C4c/d, and C3c/d in amyloid plaques in Alzheimer's disease probably result from direct binding and activation of C1 by amyloid beta peptides. RT-PCR and in situ hybridization studies have shown that several complement factors are produced in the brain parenchyma.
Veerhuis, R., Janssen, I., de Groot, C. J., van Muiswinkel, F. L., Hack, C. E., Eikelenboom, P.   +5 more
openaire   +2 more sources

Virulence Associated Gene 8 of Bordetella pertussis Enhances Contact System Activity by Inhibiting the Regulatory Function of Complement Regulator C1 Inhibitor

Frontiers in Immunology, 2018
Bordetella pertussis is a Gram-negative bacterium and the causative agent of whooping cough. Whooping cough is currently re-emerging worldwide and, therefore, still poses a continuous global health threat. B. pertussis expresses several virulence factors
Elise S. Hovingh, Elise S. Hovingh, Steven de Maat, Alexandra P. M. Cloherty, Steven Johnson, Elena Pinelli, Coen Maas, Ilse Jongerius, Ilse Jongerius   +8 more
doaj   +1 more source