SARS-CoV-2 nucleocapsid protein forms complexes with soluble complement regulatory proteins that can bind to the virion [PDF]
Scientific ReportsThe SARS-CoV-2 nucleocapsid protein has been detected in the plasma of COVID-19 patients, and its levels in the plasma correlate with the severity of the disease. It is also an immunomodulatory protein, triggering the release of proinflammatory cytokines.
Jakub Víglaský +4 more
doaj +2 more sources
PARP-3 and APLF function together to accelerate nonhomologous end joining [PDF]
, 2010 PARP-3 is a member of the ADP-ribosyl transferase superfamily of unknown function. We show that PARP-3 is stimulated by DNA double-strand breaks (DSBs) in vitro and functions in the same pathway as the poly (ADP-ribose)-binding protein APLF to accelerate
Ahel +59 more
core +1 more source
Ecallantide for the Treatment of Hereditary Angiodema in Adults
Clinical Medicine Insights: Cardiology, 2011 Hereditary angioedema (HAE) is a clinical disorder characterized by a deficiency of C1 esterase inhibitor (C1-INH). HAE has traditionally been divided into two subtypes. Unique among the inherited deficiencies of the complement system, HAE Types I and II
Michael Lunn, Erin Banta
doaj +1 more source
Complement System Part I – Molecular Mechanisms of Activation and Regulation [PDF]
, 2015 Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
Lubka T. Roumenina +3 more
core +2 more sources
Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]
, 2020 Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima +18 more
core
SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. [PDF]
, 2016 Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the ...
Abdeladhim, M. +18 more
core +1 more source
The differential ability of human IgG1 and IgG4 to activate complement is determined by the COOH-terminal sequence of the CH2 domain. [PDF]
, 1991 Using domain switch chimeric antibodies, we confirm the important role of CH2 in complement activation. In addition, we demonstrate that the structures responsible for the differential ability of human IgG1 and IgG4 to activate complement are located at ...
Canfield, SM, Morrison, SL, Tao, MH
core
Cytochromes c550, c552, c1 in the electron transport network of Paracoccus denitrificans: redundant or subtly different in function? [PDF]
, 2001 Paracoccus denitrificans strains with mutations in the genes encoding the cytochrome c550, c552, or c1 and in combinations of these genes were constructed, and their growth characteristics were determined.
Ludwig, B. +5 more
core +3 more sources
Frontiers in Immunology, 2018 Pericytes are one of the principal sources of scar-forming myofibroblasts in chronic kidneys disease. However, the modulation of pericyte-to-myofibroblast transdifferentiation (PMT) in the early phases of acute kidney injury is poorly understood.
Giuseppe Castellano +16 more
doaj +1 more source
A novel Rac1-GSPT1 signaling pathway controls astrogliosis following central nervous system injury [PDF]
, 2016 Astrogliosis (i.e. glial scar), which is comprised primarily of proliferated astrocytes at the lesion site and migrated astrocytes from neighboring regions, is one of the key reactions in determining outcomes after CNS injury.
Aiba, Atsu +12 more
core +2 more sources