Results 31 to 40 of about 21,229 (271)

Serping1/C1 Inhibitor Affects Cortical Development in a Cell Autonomous and Non-cell Autonomous Manner

Frontiers in Cellular Neuroscience, 2017
Current knowledge regarding regulation of radial neuronal migration is mainly focused on intracellular molecules. Our unbiased screen aimed at identification of non-cell autonomous mechanisms involved in this process detected differential expression of ...
Anna Gorelik, Tamar Sapir, Trent M. Woodruff, Orly Reiner   +3 more
doaj   +1 more source

Outcomes of long term treatments of type I hereditary angioedema in a Turkish family [PDF]

Anais Brasileiros de Dermatologia, 2017
: Background: Hereditary angioedema is a rare autosomal dominantly inherited immunodeficiency disorder characterized by potentially life-threatening angioedema attacks.
Gulsen Akoglu, Belgin Kesim, Gokhan Yildiz, Ahmet Metin   +3 more
doaj   +2 more sources

The Activation of JAK/STAT3 Signaling and the Complement System Modulate Inflammation in the Primary Human Dermal Fibroblasts of PXE Patients

Biomedicines, 2023
Previous studies revealed a link between inflammation and overactivation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling in syndromes associated with aging.
Christopher Lindenkamp, Ricarda Plümers, Michel R. Osterhage, Olivier M. Vanakker, Judith Van Wynsberghe, Cornelius Knabbe, Doris Hendig   +6 more
doaj   +1 more source

Complement C1-inhibitor expression in Alzheimer's disease

, 1998
In situ and in vitro studies suggest that activation of locally produced complement factors may act as a mediator between amyloid deposits and neurodegenerative changes seen in Alzheimer's disease (AD).
Hoozemans, J. J., Eikelenboom, P., Hack, C. E., Veerhuis, R, Hoozemans, JJM, Veerhuis, R., de Groot, C. J., De Groot, CJA, Eikelenboom, P, Janssen, I., Hack, CE   +10 more
core   +1 more source

Angioedema hereditario en Medellín, Colombia: evaluación clínica y de la calidad de vida

Biomédica: revista del Instituto Nacional de Salud, 2015
Introducción. El angioedema hereditario es una inmunodeficiencia primaria de carácter autosómico dominante, debida a un déficit en la proteína inhibidora del factor C1 y caracterizada por episodios recurrentes de edema subcutáneo y de las mucosas.
María Dulfary Sánchez, Julián Cuervo, Deisi Rave, Gustavo Clemen, Juan José Yepes-Núñez, Blanca Ortiz-Reyes, Sara Sus, Ricardo Cardona   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population

Frontiers in Immunology, 2018
Introduction: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to first analyze this system under ...
Mariana Gaya da Costa, Felix Poppelaars, Felix Poppelaars, Cees van Kooten, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Francesco Tedesco, Reinhard Würzner, Leendert A. Trouw, Leendert A. Trouw, Lennart Truedsson, Mohamed R. Daha, Mohamed R. Daha, Anja Roos, Marc A. Seelen   +15 more
doaj   +1 more source

C1 inhibitor: just a serine protease inhibitor? New and old considerations on therapeutic applications of C1 inhibitor

, 2008
C1 inhibitor is a potent anti-inflammatory protein as it is the major inhibitor of proteases of the contact and the complement systems. C1-inhibitor administration is an effective therapy in the treatment of patients with hereditary angioedema (HAE) who ...
Sacha Zeerleder, Wagenaar-Bos, Ineke, Ineke Wagenaar-Bos, Marieke van Ham, Wouters, Diana, Zeerleder, Sacha, Diana Wouters, van Ham, Marieke   +7 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Expression and production of the SERPING1-encoded endogenous complement regulator C1-inhibitor in multiple cohorts of tuberculosis patients. [PDF]

, 2020
BACKGROUND: To facilitate better discrimination between patients with active tuberculosis (TB) and latent TB infection (LTBI), whole blood transcriptomic studies have been performed to identify novel candidate host biomarkers.
Trouw, Leendert A., Groeneveld, Geert H, Bos, Willem J. W., Ottenhoff, Tom H. M., de Paus, Roelof A, Malherbe, Stephanus T, Dijkstra, Douwe J., Joosten, Simone A., Sutherland, Jayne S., Dijkstra, Douwe J, Gelderman, Kyra A., Vestjens, Stefan M. T., van Moorsel, Coline HM, Veltkamp, Marcel, Petrone, Linda, Malherbe, Stephanus T., Joosten, Simone A, Ottenhoff, Tom HM, Lubbers, Rosalie, Geluk, Annemieke, Bos, Willem JW, De Paus, Roelof A., Gelderman, Kyra A, Walzl, Gerhard, Groeneveld, Geert H., Sutherland, Jayne S, Goletti, Delia, Van Moorsel, Coline H. M., Vestjens, Stefan MT, Trouw, Leendert A   +29 more
core   +3 more sources