Results 11 to 20 of about 21,229 (271)

Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs

Journal of Neuroinflammation, 2004
Background Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This
McGeer Patrick L, Klegeris Andis, Hosokawa Masato   +2 more
doaj   +2 more sources

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. [PDF]

PLoS ONE, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Jasmin Schwab, Claudia Hammerschmidt, Dania Richter, Christine Skerka, Franz-Rainer Matuschka, Reinhard Wallich, Peter F Zipfel, Peter Kraiczy   +7 more
doaj   +2 more sources

A Novel C1-Esterase Inhibitor Oxygenator Coating Prevents FXII Activation in Human Blood

Biomolecules, 2020
The limited hemocompatibility of currently used oxygenator membranes prevents long-term use of artificial lungs in patients with lung failure. To improve hemocompatibility, we developed a novel covalent C1-esterase inhibitor (C1-INH) coating.
Katharina Gerling, Sabrina Ölschläger, Meltem Avci-Adali, Bernd Neumann, Ernst Schweizer, Christian Schlensak, Hans-Peter Wendel, Sandra Stoppelkamp   +7 more
doaj   +2 more sources

Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. [PDF]

PLoS Pathogens, 2016
Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system.
Brandon L Garcia, Hui Zhi, Beau Wager, Magnus Höök, Jon T Skare   +4 more
doaj   +3 more sources

A Case of Angioedema Associated with Decreased C1 Inhibitor Activity

Allergology International, 2007
Background: We report a case of a 31-year-old woman who began to notice swelling of her arms at age 20. She was once given a diagnosis of cellulitis, but her symptoms spontaneously resolved.
Chizuko Yano, Arihito Ota, Hidemi Nakagawa   +2 more
doaj   +2 more sources

Serum concentrations of C reactive protein, α₁antitrypsin, and complement (C3, C4, C1 esterase inhibitor) before and during the Vuelta a Espańa [PDF]

British Journal of Sports Medicine, 2006
Objectives:To determine serum concentrations of proinflammatory (C reactive protein, complement C3 and C4) and anti-inflammatory (α1antitrypsin, C1 esterase inhibitor (C1-INH)) acute phase proteins in elite cyclists before and during a three week cycle tour.Methods:Seventeen professional cyclists participating in the Vuelta a Espańa volunteered for the
Semple, Stuart, Smith, L. L., McKune, Andrew J., Hoyos, J., Mokgethwa, B., San Juan, Alejandro F., Lucía Mulas, Alejandro, Wadee, Ahmed   +7 more
openaire   +5 more sources

Virulence Associated Gene 8 of Bordetella pertussis Enhances Contact System Activity by Inhibiting the Regulatory Function of Complement Regulator C1 Inhibitor [PDF]

Frontiers in Immunology, 2018
Bordetella pertussis is a Gram-negative bacterium and the causative agent of whooping cough. Whooping cough is currently re-emerging worldwide and, therefore, still poses a continuous global health threat. B. pertussis expresses several virulence factors
Elise S. Hovingh, Elise S. Hovingh, Steven de Maat, Alexandra P. M. Cloherty, Steven Johnson, Elena Pinelli, Coen Maas, Ilse Jongerius, Ilse Jongerius   +8 more
doaj   +2 more sources

Recombinant Human C1 Esterase Inhibitor for the Management of Adverse Events Related to Intravenous Immunoglobulin Infusion in Patients With Common Variable Immunodeficiency or Polyneuropathy: A Pilot Open-Label Study

Frontiers in Immunology, 2021
It has been hypothesized that low levels of C1 esterase inhibitor (C1-INH), a key inhibitor of the complement pathway, may play a role in the occurrence of adverse events (AEs) associated with intravenous immunoglobulin (IVIG) therapy.
Isaac R. Melamed, Holly Miranda, Melinda Heffron, Joseph R. Harper   +3 more
doaj   +1 more source

Periodic Severe Angioedema without Exogenous Hormone Exposure

Iranian Journal of Allergy, Asthma and Immunology, 2021
Hereditary angioedema (HAE) is characterized by recurrent attacks of skin and mucosal swelling in any part of the body including the digestive and respiratory tract which generally improve spontaneously within 12-72 hours. The underlying mechanism in HAE
Mohammad Nabavi, Sima Bahrami, Saba Arshi, Afshin Rezaeifar, Mohammad Hassan Bemanian, Morteza Fallahpour, Sima Shokri, Homan Tehrani   +7 more
doaj   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Schmid, Ralf, Schwaeble, Wilhelm J., Wilhelm J. Schwaeble, Anthony H. Keeble, Russell Wallis, Mitchell, Daniel A., Keeble, Anthony H., Wallis, Russell, Ralf Schmid, Daniel A. Mitchell   +9 more
core   +1 more source