Results 21 to 30 of about 4,257,255 (225)

Monocyte C1-Inhibitor Synthesis [PDF]

, 1987
C1-inhibitor is the major control protein of the classical pathway of complement. In man, its hereditary deficiency results in the clinical condition of hereditary angio-oedema (HAE).
Jones, Linda Margaret
core   +6 more sources

Periodic Severe Angioedema without Exogenous Hormone Exposure

Iranian Journal of Allergy, Asthma and Immunology, 2021
Hereditary angioedema (HAE) is characterized by recurrent attacks of skin and mucosal swelling in any part of the body including the digestive and respiratory tract which generally improve spontaneously within 12-72 hours. The underlying mechanism in HAE
Mohammad Nabavi, Sima Bahrami, Saba Arshi, Afshin Rezaeifar, Mohammad Hassan Bemanian, Morteza Fallahpour, Sima Shokri, Homan Tehrani   +7 more
doaj   +1 more source

A Novel C1-Esterase Inhibitor Oxygenator Coating Prevents FXII Activation in Human Blood

Biomolecules, 2020
The limited hemocompatibility of currently used oxygenator membranes prevents long-term use of artificial lungs in patients with lung failure. To improve hemocompatibility, we developed a novel covalent C1-esterase inhibitor (C1-INH) coating.
Katharina Gerling, Sabrina Ölschläger, Meltem Avci-Adali, Bernd Neumann, Ernst Schweizer, Christian Schlensak, Hans-Peter Wendel, Sandra Stoppelkamp   +7 more
doaj   +1 more source

Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs

Journal of Neuroinflammation, 2004
Background Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This
McGeer Patrick L, Klegeris Andis, Hosokawa Masato   +2 more
doaj   +1 more source

Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. [PDF]

PLoS Pathogens, 2016
Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system.
Brandon L Garcia, Hui Zhi, Beau Wager, Magnus Höök, Jon T Skare   +4 more
doaj   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Schmid, Ralf, Schwaeble, Wilhelm J., Wilhelm J. Schwaeble, Anthony H. Keeble, Russell Wallis, Mitchell, Daniel A., Keeble, Anthony H., Wallis, Russell, Ralf Schmid, Daniel A. Mitchell   +9 more
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DYNAMICS OF ACTIVITY OF SOME COMPONENTS OF COMPLEMENT IN TREATMENT OF ATOPIC DERMATITIS IN CHILDREN

Детские инфекции (Москва), 2015
The article describes immunoassay methods of determining the functional activity of the components C3 and C9 and C1 inhibitor for diagnostic and prognostic purposes in the treatment of patients.
S. S. Andina, A. M. Bichucher, N. V. Gora, L. V. Kozlov, O. V. Logunov, O. A. Bashkina, O. V. Rubalsky, A. V. Aleshkin   +7 more
doaj   +1 more source

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Toth, Julia, Wilhelm J. Schwaeble, Christopher Furze, Russell Wallis, Keeble, A. H., Julia Toth, Keeble, Anthony H., Girija, Umakhanth Venkatraman, Wallis, Russell, Mitchell, D. A., Daniel A. Mitchell, Toth, J., Schwaeble, W. J., Schwaeble, Wilhelm J., Anthony H. Keeble, Furze, C., Umakhanth Venkatraman Girija, Furze, Christopher M., Mitchell, Daniel A., Wallis, R., Venkatraman Girija, U.   +20 more
core   +1 more source

A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. [PDF]

, 2010
Viruses have evolved to evade the host's complement system. The open reading frames 4 (ORF4) of gammaherpesviruses encode homologs of regulators of complement activation (RCA) proteins, which inhibit complement activation at the level of C3 and C4 ...
Stewart, James P., Stipan, J., Adler, Heiko, James P Stewart, Adler Barbara, Adler, Barbara, Heiko Adler, Beatrix Steer, Barbara Adler, Jonjic Stipan, Stipan Jonjic, Steer, Beatrix, Steer Beatrix, Steer, B., Adler Heiko, Stewart James P., Adler, H., Adler, B., Jonjic, Stipan, James P. Stewart, Stewart, J.P.   +20 more
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Application of a dried blood spot based proteomic and genetic assay for diagnosing hereditary angioedema

Clinical and Translational Allergy, 2023
Background Hereditary angioedema (HAE) with C1‐inhibitor deficiency (C1‐INH‐HAE) is a rare disease caused by low level (type I) or dysfunction (type II) of the C1‐inhibitor protein with subsequent reduction of certain complement protein levels.
Marius‐Ionuţ Iuraşcu, Zsuzsanna Balla, Catarina Pereira, Noémi Andrási, Lilian Varga, Dorottya Csuka, Ágnes Szilágyi, Kornelia Tripolszki, Suliman Khan, Iuliana Susnea, Peter Bauer, Claudia Cozma, Henriette Farkas   +12 more
doaj   +1 more source