Results 1 to 10 of about 214,320 (304)
PARP inhibition: a promising therapeutic target in ovarian cancer [PDF]
, 2015 Ovarian cancer is burdened by the highest mortality rate among gynecological cancers. Gold standard is represented by the association of platinum-taxane -based chemotherapy and radical surgery.
Abdul Halim, T +14 more
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Herediter anjioödemde kısa dönem danazol profilaksisi ile implant tedavisi: Vaka raporu
Selcuk Dental Journal, 2019 Herediter anjio ödem (HAÖ), C1 esteraz inhibitör proteininin konjenital eksikliğine bağlı olarak meydana gelen, nadir gözlenen, otozomal dominant bir hastalıktır. HAÖ atakları, spontan veya bir travmaya bağlı olarak, ekstremitelerde, yüzde, göğüste, hava
Zeynep Burçin Gönen +4 more
doaj +1 more source
Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy [PDF]
, 2014 BRCA1, a key factor in homologous recombination repair may also regulate base excision repair (BER). Targeting BRCA1-BER deficient cells by blockade of ATM and DNA-PKcs could be a promising strategy in breast cancer.
Abdel-Fatah, TMA +16 more
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Emerging treatment options for the management of brain metastases in patients with HER2-positive metastatic breast cancer. [PDF]
, 2013 The widespread use of trastuzumab in the past decade has led to a significant and measureable improvement in the survival of patients with human epidermal growth factor receptor-2 (HER2) overexpressing breast cancer, and in many ways has redefined the ...
Chien, A Jo, Rugo, Hope S
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Orphanet Journal of Rare Diseases, 2018 Background Bradykinin-mediated angioedema (Bk-AE) can be life-threatening and requires specific targeted therapies. Knowledge of its epidemiology may help optimize its management.
Emel Aygören-Pürsün +3 more
doaj +1 more source
Coordinate-independent singular perturbation reduction for systems with three time scales
, 2019 On the basis of recent work by Cardin and Teixeira on ordinary differential equations with more than two time scales, we devise a coordinate-independent reduction for systems with three time scales; thus no a priori separation of variables into fast ...
Kruff, Niclas, Walcher, Sebastian
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Frontiers in Medicine, 2019 Abdominal pain due to intestinal swellings is one of the most common manifestations in hereditary angioedema (HAE). Bowel swellings can cause severe abdominal pain, nausea, vomiting, and diarrhea, which may lead to misdiagnosis of gastrointestinal ...
Camila Lopes Veronez +5 more
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Characterization of carbohydrate chains of C1‐inhibitor and of desialylated C1‐inhibitor
FEBS Letters, 1992 Carbohydrate chains of C1‐inhibitor were identified with a binding assay using different lectins. Lectins from Sambucus nigra (SNA) and Maackia amurensis (MAA) that are specific for sialic acids bound to C1‐inhibitor. Lectin from Datura strantonium (DSA) reacted also with the inhibitor indicating complex and hybrid sugar structures.
openaire +2 more sources
A CASE OF ANGIOEDEMA: C1 INHIBITOR DEFICIENCY
National Journal of Medical Research, 2015 Angioedema is rapid swelling (oedema) of subcutaneous tissue involving dermis, mucosa and sub mucosal tissues. It may be IgE dependant, bradykinin mediated, complement mediated, non immunologic or idiopathic. It may be heriditory or acquired.
Arijit Sinha +5 more
doaj
, 2017 Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient sensing and longevity-assuring enzyme SIRT6 on the dynamics of apoptosis ...
Domanskyi, Sergii +4 more
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