Results 51 to 60 of about 21,229 (271)

Monocyte C1-Inhibitor Synthesis [PDF]

, 1987
C1-inhibitor is the major control protein of the classical pathway of complement. In man, its hereditary deficiency results in the clinical condition of hereditary angio-oedema (HAE).
Jones, Linda Margaret
core  

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction

, 2015
Complement activation contributes significantly to inflammation-related damage in the heart after acute myocardial infarction. Knowledge on factors that regulate postinfraction complement activation is incomplete however.
Hans W.M. Niessen, Reindert W. Emmens, Lynda J.M. Juffermans, Niessen, Hans W. M., Karia, Rashmi V., Sacha Zeerleder, Paul A.J. Krijnen, Simsek, Suat, Ylstra, Bauke, Juffermans, Lynda J. M., Krijnen, Paul A. J., Bauke Ylstra, Marieke van Ham, Umit Baylan, Wouters, Diana, Zeerleder, Sacha, Suat Simsek, Emmens, Reindert W., Diana Wouters, Baylan, Umit, van Ham, Marieke, Rashmi V. Karia   +21 more
core   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

C1-esterase inhibitor attenuates the inflammatory response during human endotoxemia.

, 2010
Contains fulltext : 88360.pdf (Publisher’s version ) (Open Access)OBJECTIVE: Besides its role in regulation of the complement and contact system, C1-esterase inhibitor has other immunomodulating effects that could prove beneficial in ...
Pillay, J., Dorresteijn, M.J., Koenderman, A.H., Strengers, P.F.W., Koenderman, L., Pickkers, P., Visser, T., Leenen, L.P.H., Bouw, M.P.W.J.M., Hoeven, J.G. van der, Cox, L.A.   +10 more
core   +1 more source

Increased plasma concentrations of complement modulating proteins (C1 inhibitor, C4-binding protein, factor H and factor I) in psoriasis.

The Tohoku Journal of Experimental Medicine, 1988
By using single radial immunodiffusion we measured the plasma levels of four complement modulating proteins, i.e., C1 inhibitor, C4-binding protein, factor H and factor I in 19 psoriatic patients in comparison with those of healthy controls. Except for C1 inhibitor which was only marginally elevated, they were found to be significantly increased in ...
OHKOHCHI, KYOKO, TORINUKI, WAKIO, TAGAMI, HACHIRO   +2 more
openaire   +3 more sources

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Endothelial Cells Cultured from Human Brain Microvessels Produce Complement Proteins Factor H, Factor B, C1 Inhibitor, and C4

Immunobiology, 1998
The inflammatory mediators, cytokines and complement proteins are believed to regulate the sequential events during the development of lesions secondary to ischaemia and reperfusion. The endothelial cell monolayer of the brain microvasculature is the critical interface between the blood-borne mediators and brain tissue.
M, Vastag, J, Skopál, J, Kramer, K, Kolev, Z, Vokó, E, Csonka, R, Machovich, Z, Nagy   +7 more
openaire   +2 more sources

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Hereditary angioedema: a disease seldom diagnosed by pediatricians

Jornal de Pediatria, 2021
Objectives: To describe the hereditary angioedema to improve awareness of this condition and reduce diagnostic delay. Data sources: Relevant articles in the MEDLINE database through PubMed.
Régis de Albuquerque Campos, Solange Oliveira Rodrigues Valle, Eliana Cristina Toledo   +2 more
doaj   +1 more source