Results 301 to 310 of about 3,095,271 (376)

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Rare connective tissue diseases in patients with C1-inhibitor deficiency hereditary angioedema: first evidence on prevalence and distribution from a large Italian cohort study. [PDF]

Front Immunol
Triggianese P, Senter R, Perego F, Gidaro A, Petraroli A, Arcoleo F, Brussino L, Giardino F, Rossi O, Bignardi D, Quattrocchi P, Brancaccio R, Cesoni Marcelli A, Accardo PA, Lo Sardo L, Cataudella E, Guarino MD, Firinu D, Bergamini A, Spadaro G, Zanichelli A, Cancian M.   +21 more
europepmc   +1 more source

Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.

Blood, 2016
L. Wijeyewickrema, Emilie Lameignère, L. Hor, R. Duncan, T. Shiba, R. Travers, P. Kapopara, V. Lei, Stephanie A. Smith, Hugh Kim, J. Morrissey, R. Pike, E. Conway   +12 more
semanticscholar   +1 more source

H⁺ Exchange‐Driven ppb‐Level and High‐Selective Formaldehyde Detection at Room Temperature for Environmental and Clinical Applications

Advanced Science, EarlyView.
This article presents an innovative room‐temperature formaldehyde sensor based on H⁺ exchange method, achieving ppb‐level detection limit and exceptional selectivity. The study highlights its practical potential for real‐time environmental monitoring and clinical diagnostic applications.
Lubing Cai, Mengyang Pang, Zhaosong Liu, Yanfei Li, Jiani Li, Zhaorui Zhang, Fengshuang Zheng, Chao Li, Ang Zheng, Xuemin Zhang   +9 more
wiley   +1 more source

Managing Primary Immunodeficiency Immunoglobulin Replacement Therapy‐Related Adverse Events With Recombinant Human C1 Esterase Inhibitor Prophylaxis: A Case Report

Douglas H. Jones, Heidi Memmott
openalex   +1 more source

Hierarchical Strain‐Modified Medium‐Entropy Carbide Ceramics Exhibit Exceptional Ablation Resistance up to 2400°C

Advanced Science, EarlyView.
A novel strategy is developed by doping reduced graphene oxide (rGO) into a (HfZrTi)C medium‐entropy ceramic. This induces a hierarchical strain modification mechanism, synergistically inhibiting crack propagation at the microscale and dissipating stress at the mesoscale.
Junyi Xiao, Pengfei He, Lin Xue, Shujun Hu, Liliang Shao, Chuan Sun, Yunyun Ge, Jiangbo Cheng, Xiubing Liang   +8 more
wiley   +1 more source

[High expression of apolipoprotein C1 promotes proliferation and inhibits apoptosis of papillary thyroid carcinoma cells by activating the JAK2/STAT3 signaling pathway].

Bin Yu, Ziwen Li, Song Zuo, Sinuo Sun, Min Li, Jiayin Song, Lin Xu, Gang Xue, Jingfang Wu   +8 more
openalex   +2 more sources

Hierarchically Porous Nitrogen‐Doped Carbon with High Conductivity for Rapid and Efficient Cr(VI) Reduction

Advanced Science, EarlyView.
The d‐PNC(1100, 10%) catalyst, synthesized via a zinc‐based ionic liquid self‐sacrificing pore‐forming strategy to create a defect‐rich, hierarchical, nitrogen‐doped porous structure, enhances conductivity, promotes rapid mass transfer and synergistic catalytic activity, driving efficient Cr(VI) reduction in OA solution to generate Cr(III)‐OA complexes.
Danyan Lin, Jie Yang, Fengfeng Chen, Xishi Tai, Zhongshan Chen, Xinrong Guo, Xiangke Wang, Wen Yao   +7 more
wiley   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Acquired angioedema with C1-inhibitor deficiency: similarities and differences with hereditary angioedema

, 2019
Noémi‐Anna Bara, Valentin Nădășan
openalex   +1 more source