Results 311 to 320 of about 3,095,271 (376)

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Berotralstat in hereditary angioedema due to C1 inhibitor deficiency: first real-world evidence from a Canadian center. [PDF]

Front Immunol
Srinivasan C, Ritchie B, Adatia A.
europepmc   +1 more source

Unveiling a Stable Polysulfide Transport Framework in a Fluorine‐Free Li‐S Batteries

Advanced Science, EarlyView.
This work unveils a lithium thiophosphate reaction pathway activated by trigger P2S5 units, which initiate fast self‐assembly and shift the system away from conventional Li‐S reactions. The reversible Li‐P‐S framework delivers stability, safety, and high energy density, while enabling a distinct solid‐liquid hybrid electrochemical mode that provides a ...
Feng‐Yu Wu, Po‐Wei Chi, Phillip M. Wu, Maw‐Kuen Wu   +3 more
wiley   +1 more source

Association of Endothelial Cell Activation with Acute Kidney Injury during Coronary Angiography and the Influence of Recombinant Human C1 Inhibitor-A Secondary Analysis of a Randomized, Placebo-Controlled, Double-Blind Trial. [PDF]

Biomedicines
Moser S, Araschmid L, Panagiotou A, Bonati LH, Breidthardt T, Fahrni G, Kaiser C, Jeger R, Trendelenburg M, Osthoff M.   +9 more
europepmc   +1 more source

Single‐Cell Transcriptomic Atlases of Camels and Cattle Unravel Molecular Evolution of Digestive and Metabolic Systems

Advanced Science, EarlyView.
We generated multi‐tissue single‐cell transcriptomic atlases of camels and cattle, uncovering conserved and lineage‐specific cellular features across digestive and metabolic systems. Cross‐species comparisons revealed the evolutionary origin of the camel glandular sac and identified novel cell populations linked to physiological specialization ...
Tao Shi, Huiquan Shan, Haoping Wang, Xi Guo, Houcheng Li, Bo Han, Senlin Zhu, Fei Wang, Guanghui Tan, Zhannur Niyazbekova, Jilong Ren, Yaqi Zhou, Qi Zhang, Weijie Zheng, Minghui Jia, Ao Zhang, Xuesha Cao, Huizeng Sun, Dongxiao Sun, Lingzhao Fang, Yi Zheng, Xihong Wang, Yu Jiang   +22 more
wiley   +1 more source

Tailored Organogel Systems for Optimized Pesticide Delivery: Mechanistic Insights and Agricultural Applications

Advanced Science, EarlyView.
Utilizing molecular engineering for network design, three pesticide‐loaded organogels (PLOs) carriers exhibiting varying degrees of flexibility were prepared. The mechanical properties of these carriers, tunable via their network molecular structures, enhance their structural adaptability and retention stability at biological interfaces, thereby ...
Yue Wang, SiYu Xv, Chao Wu, Nan Li, GuoPeng Teng, XuePing Huang, Jian Luo   +6 more
wiley   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Acute Abdominal Pain as the Initial Presentation of an Acquired C1 Inhibitor Deficiency. [PDF]

GE Port J Gastroenterol
Pinto AR, Carolino F.
europepmc   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Beyond Sabatier: Multiplicate Spillover Phenomena for Manipulating Catalytic Dynamics in Various Electrocatalysis

Advanced Science, EarlyView.
Various spillover‐mediated electrocatalytic reactions, such as hydrogen and oxygen evolution, carbon dioxide and nitrogen reduction, and methanol oxidization reactions, are systematically summarized. Abstract Spillover phenomenon, which is characterized by the dynamic migration of active species across catalyst surfaces, provides a promising avenue to ...
Di Wang, Ziyou Dong, Qianqian Yao, Shixue Dou, Jun Mei, Ziqi Sun   +5 more
wiley   +1 more source