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Deficiencies of C1 inhibitor

Best Practice & Research Clinical Gastroenterology, 2005
Hereditary and acquired deficiencies of the C1 inhibitor result in a single prominent symptom, namely angioedema. Angioedema may involve the skin, the gastrointestinal tract or the upper airway. Genetically determined defects in C1INH cause hereditary angioedema.
Fred S, Rosen, Alvin E, Davis
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C1-2 arthrography

Skeletal Radiology, 1995
To describe the technique of C1-2 arthrography and recommend it as a suitable treatment for pain due to C1-2 abnormalities.One hundred patients with the following conditions were studied: cervical pain or neuralgia without radiographic changes (group 1, n = 23), osteoarthritis (group 2, n = 37), rheumatoid arthritis (group 3, n = 23), ankylosing ...
A, Chevrot   +6 more
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C1s

2018
International ...
Thielens, Nicole   +2 more
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Interaction of C1-inhibitor with the C1r and C1s subcomponents in human C1.

Biochimica et biophysica acta, 1979
1. Insoluble IgG-ovalbumin aggregates were used to bind and activate C1 from human serum. The bound C1 provided a useful reagent for studying the interaction of C1 subcomponents with C1-inhibitor. 2. C1-inhibitor bound to both subcomponents (C1r and C1s in C1 and formed stable complexes of respective apparent molecular weights 197,000 and 185,000, as ...
G J, Arlaud   +3 more
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C1 inhibitor: different mechanisms of reaction with complement component C1 and C1s.

Immunological investigations, 1991
Inactivation of human complement subcomponent C1-s by its regulator C1 inhibitor at physiological ionic strength proceeded at a 3-fold higher rate when C1-s was in the physiological C1- complex with subcomponents C1q and C1-r rather than as purified subunit.
G L, Hortin, B L, Trimpe
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Empower C1: Combination of Electrochemistry and Biology to Convert C1 Compounds

2021
The idea to somehow combine electrical current and biological systems is not new. It was subject of research as well as of science fiction literature for decades. Nowadays, in times of limited resources and the need to capture greenhouse gases like CO2, this combination gains increasing interest, since it might allow to use C1 compounds and highly ...
Franziska, Enzmann   +3 more
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Unique C1 inhibitor dysfunction in a kindred without angioedema. I. A mutant C1 INH that inhibits C1-s but not C1-r.

The Journal of Immunology, 1994
Abstract We have described hereditary incomplete deficiency of the fourth component of complement (C4) in 10 members of a large kindred. C4 deficiency in this kindred is not linked to C4 loci in the HLA region. C4 synthesis is decreased, and C4 catabolism is normal in kindred members with low serum C4 levels.
J J, Wisnieski   +5 more
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???????????????? ???????????????????????????? ???????? ???? ????????????, ?????? ???????????????? C1-????????????, ?????? ???? C1+??-????????????

2020
We prove the existence of two real-analytic diffeomorphisms of the circle with break of the same size and an irrational rotation number of semibounded type that are not C1+??-smoothly conjugate for any ?? > 0. In this way, we show that the previous result concerning the C1-smoothness of conjugacy for these mappings is the exact estimate of smoothness ...
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Spontaneous activation of serum C1 in vitro. Role of C1 inhibitor

The Journal of Immunology, 1991
Abstract The temperature and ionic strength dependence of the spontaneous activation of C1 were determined for normal human serum, and the free energy, enthalpy, and entropy of spontaneous activation were calculated. The half-life of C1 in human serum was approximately 15 h at 37 degrees C.
Y, Tseng   +3 more
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Probing the structure of C1 with an anti-C1s monoclonal antibody: the possible existence of two forms of C1 in solution

Molecular Immunology, 1997
Anti-human C1s monoclonal antibody H1532, a mouse gamma-1-immunoglobulin elicited by a C1r2C1s2 immunogen, appeared to bind to the beta-domain of C1s by electron microscopy. In agreement with this observation, Western blotting demonstrated good binding to unreduced C1s, but no binding to the alpha or gamma-B domains.
Y, Tseng, M L, Phillips, V N, Schumaker
openaire   +2 more sources

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