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Role of the inflammasome in chronic obstructive pulmonary disease (COPD).
, 2017 Sorrentino, R. +4 more
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Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1984
Abstract The first component of complement, C1, is a calcium-dependent complex of two loosely interacting subunits: C1q, responsible for the binding of activators to C1; C1r2—C1s2, which supports the autoactivation potential of C1, together with the proteolytic activity of activated C1 on its two substrates, C4 and C2.
M G, Colomb, G J, Arlaud, C L, Villiers
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Abstract The first component of complement, C1, is a calcium-dependent complex of two loosely interacting subunits: C1q, responsible for the binding of activators to C1; C1r2—C1s2, which supports the autoactivation potential of C1, together with the proteolytic activity of activated C1 on its two substrates, C4 and C2.
M G, Colomb, G J, Arlaud, C L, Villiers
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C1s Bound in Macromolecular C1 Exists in Equilibrium with C1s Free in Serum
The Journal of Immunology, 1978Abstract We have established the existence of an equilibrium between free C1s and C1s bound in macromolecular C1 in human serum. Untreated human sera were incubated for 35 hours at 4°C with 125I-C1s to allow the exchange between free and bound C1s to reach equilibrium.
R M Bartholomew, A F Esser
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The Journal of Immunology, 1970
Abstract Highly purified C1s has been obtained by immunization of rabbits using popliteal node injections of highly purified C1s followed by booster injections with gel segments containing C1s after disc-acrylamide gel electrophoresis.
K Nagaki, R M Stroud
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Abstract Highly purified C1s has been obtained by immunization of rabbits using popliteal node injections of highly purified C1s followed by booster injections with gel segments containing C1s after disc-acrylamide gel electrophoresis.
K Nagaki, R M Stroud
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The Journal of Immunology, 2000
Abstract The activation of the C1s-C1r-C1r-C1s tetramer in the C1 complex, which involves the cleavage of an Arg-Ile bond in the catalytic domains of the subcomponents, is a two-step process. First, the autolytic activation of C1r takes place, then activated C1r cleaves zymogen C1s. The Arg463Gln mutant of C1r (C1rQI) is stabilized in
Z, Lörincz +6 more
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Abstract The activation of the C1s-C1r-C1r-C1s tetramer in the C1 complex, which involves the cleavage of an Arg-Ile bond in the catalytic domains of the subcomponents, is a two-step process. First, the autolytic activation of C1r takes place, then activated C1r cleaves zymogen C1s. The Arg463Gln mutant of C1r (C1rQI) is stabilized in
Z, Lörincz +6 more
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Best Practice & Research Clinical Gastroenterology, 2005
Hereditary and acquired deficiencies of the C1 inhibitor result in a single prominent symptom, namely angioedema. Angioedema may involve the skin, the gastrointestinal tract or the upper airway. Genetically determined defects in C1INH cause hereditary angioedema.
Fred S, Rosen, Alvin E, Davis
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Hereditary and acquired deficiencies of the C1 inhibitor result in a single prominent symptom, namely angioedema. Angioedema may involve the skin, the gastrointestinal tract or the upper airway. Genetically determined defects in C1INH cause hereditary angioedema.
Fred S, Rosen, Alvin E, Davis
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Skeletal Radiology, 1995
To describe the technique of C1-2 arthrography and recommend it as a suitable treatment for pain due to C1-2 abnormalities.One hundred patients with the following conditions were studied: cervical pain or neuralgia without radiographic changes (group 1, n = 23), osteoarthritis (group 2, n = 37), rheumatoid arthritis (group 3, n = 23), ankylosing ...
A, Chevrot +6 more
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To describe the technique of C1-2 arthrography and recommend it as a suitable treatment for pain due to C1-2 abnormalities.One hundred patients with the following conditions were studied: cervical pain or neuralgia without radiographic changes (group 1, n = 23), osteoarthritis (group 2, n = 37), rheumatoid arthritis (group 3, n = 23), ankylosing ...
A, Chevrot +6 more
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Interaction of C1-inhibitor with the C1r and C1s subcomponents in human C1.
Biochimica et biophysica acta, 19791. Insoluble IgG-ovalbumin aggregates were used to bind and activate C1 from human serum. The bound C1 provided a useful reagent for studying the interaction of C1 subcomponents with C1-inhibitor. 2. C1-inhibitor bound to both subcomponents (C1r and C1s in C1 and formed stable complexes of respective apparent molecular weights 197,000 and 185,000, as ...
G J, Arlaud +3 more
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