Results 261 to 270 of about 575,689 (289)
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C1 inhibitor: different mechanisms of reaction with complement component C1 and C1s.
Immunological investigations, 1991Inactivation of human complement subcomponent C1-s by its regulator C1 inhibitor at physiological ionic strength proceeded at a 3-fold higher rate when C1-s was in the physiological C1- complex with subcomponents C1q and C1-r rather than as purified subunit.
G L, Hortin, B L, Trimpe
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Empower C1: Combination of Electrochemistry and Biology to Convert C1 Compounds
2021The idea to somehow combine electrical current and biological systems is not new. It was subject of research as well as of science fiction literature for decades. Nowadays, in times of limited resources and the need to capture greenhouse gases like CO2, this combination gains increasing interest, since it might allow to use C1 compounds and highly ...
Franziska, Enzmann +3 more
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The Journal of Immunology, 1994
Abstract We have described hereditary incomplete deficiency of the fourth component of complement (C4) in 10 members of a large kindred. C4 deficiency in this kindred is not linked to C4 loci in the HLA region. C4 synthesis is decreased, and C4 catabolism is normal in kindred members with low serum C4 levels.
J J, Wisnieski +5 more
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Abstract We have described hereditary incomplete deficiency of the fourth component of complement (C4) in 10 members of a large kindred. C4 deficiency in this kindred is not linked to C4 loci in the HLA region. C4 synthesis is decreased, and C4 catabolism is normal in kindred members with low serum C4 levels.
J J, Wisnieski +5 more
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Monocyte C1‐inhibitor synthesis in patients with C1‐inhibitor deficiency
European Journal of Clinical Investigation, 1989Abstract. Monocytes of seven out of eight patients with type 1 C1‐inhibitor (C1‐inh) deficiency (HAE) produced 40% as much C1‐inh as monocytes from normal donors (controls). In contrast, monocytes from three patients with type 2 and three patients with acquired C1‐inh deficiency produced similar amounts of Cl‐inh as controls. Recombinant γ‐interferon (
D F, Lappin +6 more
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Molecular Immunology, 1997
Anti-human C1s monoclonal antibody H1532, a mouse gamma-1-immunoglobulin elicited by a C1r2C1s2 immunogen, appeared to bind to the beta-domain of C1s by electron microscopy. In agreement with this observation, Western blotting demonstrated good binding to unreduced C1s, but no binding to the alpha or gamma-B domains.
Y, Tseng, M L, Phillips, V N, Schumaker
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Anti-human C1s monoclonal antibody H1532, a mouse gamma-1-immunoglobulin elicited by a C1r2C1s2 immunogen, appeared to bind to the beta-domain of C1s by electron microscopy. In agreement with this observation, Western blotting demonstrated good binding to unreduced C1s, but no binding to the alpha or gamma-B domains.
Y, Tseng, M L, Phillips, V N, Schumaker
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2020
We prove the existence of two real-analytic diffeomorphisms of the circle with break of the same size and an irrational rotation number of semibounded type that are not C1+??-smoothly conjugate for any ?? > 0. In this way, we show that the previous result concerning the C1-smoothness of conjugacy for these mappings is the exact estimate of smoothness ...
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We prove the existence of two real-analytic diffeomorphisms of the circle with break of the same size and an irrational rotation number of semibounded type that are not C1+??-smoothly conjugate for any ?? > 0. In this way, we show that the previous result concerning the C1-smoothness of conjugacy for these mappings is the exact estimate of smoothness ...
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Spontaneous activation of serum C1 in vitro. Role of C1 inhibitor
The Journal of Immunology, 1991Abstract The temperature and ionic strength dependence of the spontaneous activation of C1 were determined for normal human serum, and the free energy, enthalpy, and entropy of spontaneous activation were calculated. The half-life of C1 in human serum was approximately 15 h at 37 degrees C.
Y, Tseng +3 more
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The Journal of Immunology, 1977
Abstract An equilibrium between free C1s and C1s bound in macromolecular C1 exists in human serum. This equilibrium can be utilized to incorporate radioiodinated C1s into serum C1. Human sera were incubated for 40 hr at 4°C with 125I-C1s to allow the exchange between free and bound C1s to reach equilibrium. The C1 complex labeled in this
R M, Bartholomew, A F, Esser
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Abstract An equilibrium between free C1s and C1s bound in macromolecular C1 exists in human serum. This equilibrium can be utilized to incorporate radioiodinated C1s into serum C1. Human sera were incubated for 40 hr at 4°C with 125I-C1s to allow the exchange between free and bound C1s to reach equilibrium. The C1 complex labeled in this
R M, Bartholomew, A F, Esser
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Regulation of the synthesis of C1 subcomponents and C1-inhibitor.
Behring Institute Mitteilungen, 1994We have investigated the synthesis of C1q, C1r, C1s and C1-inhibitor in HepG2 cells, human umbilical vein endothelial cells (HUVEC), fibroblasts (skin and synovial membrane), chondrocytes and monocytes. C1q was only synthesised by monocytes, although the mRNAs for the C1qA and C1qC chains were expressed in HUVEC.
P, Gulati +4 more
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Kinetics of interaction of C1 inhibitor with complement C1s.
Biochemistry, 1986The kinetics of inhibition of the complement serine protease, C1s, by its only known inhibitor, C1 inhibitor, have been measured by a variety of methods. One method continuously monitors the loss of esterolytic activity with a synthetic substrate coupled to a chromogen while another monitors the formation of a stable (covalent) complex by high-pressure
M, Lennick, S A, Brew, K C, Ingham
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