Complement C1r serine protease contributes to kidney fibrosis
American Journal of Physiology - Renal Physiology, 2019 We reported that complement activation precedes the development of kidney fibrosis, however, little is known about the cellular mechanisms involved in this transition.
Sandhya Xavier +2 more
exaly +3 more sources
Clinical presentations and molecular basis of complement C1R mutation in a large turkish family [PDF]
Pediatr Rheumatol Online J, 2014 Inherited deficiencies of complement components can result in autoimmunity. Early age of onset, prominent cutaneous manifestations, and presence of anti-Ro antibodies are features suggestive of a complement deficiency.
E. Demirkaya +6 more
core +3 more sources
Complement Components C1r and C8 Serve as Potential Inflammatory Biomarkers for Coronary Heart Disease Severity: The Mediating Role of C-Reactive Protein [PDF]
Journal of Inflammation ResearchXia Feng,1– 4,* Xiaoting Jiang,1– 4,* Shaolin Gong,1– 4,* Wen Liu,1– 4 Qiong Yan,1 Hongmei Qi,1 Ling Yu,1 Xiang Wang,1– 4 Xiaoping Peng1– 4 1Department of Cardiology, The First Affiliated Hospital, Jiangxi Medical College ...
Feng X +8 more
doaj +3 more sources
C1R Mutations Trigger Constitutive Complement 1 Activation in Periodontal Ehlers-Danlos Syndrome
Frontiers in Immunology, 2019 Heterozygous missense or in-frame insertion/deletion mutations in complement 1 subunits C1r and C1s cause periodontal Ehlers-Danlos Syndrome (pEDS), a specific EDS subtype characterized by early severe periodontal destruction and connective tissue ...
Inés Kapferer-Seebacher +2 more
exaly +4 more sources
Frontiers in BioscienceBackground: Mounting evidence indicates that complement components play a crucial role in cancer progression. Recent findings indicate that certain complement components display a significant rise in expression within esophageal squamous cell carcinoma ...
Maolin Tang
exaly +4 more sources
BBK32 attenuates antibody-dependent complement-mediated killing of infectious Borreliella burgdorferi isolates. [PDF]
PLoS PathogensBorreliella burgdorferi, the causative agent of Lyme disease, has evolved unique complement evasion proteins that promote its ability to establish and maintain infection in mammalian hosts. Among these is B.
Alexandra D Powell-Pierce +6 more
doaj +3 more sources
Blocking activation of the C1r zymogen defines a novel mode of complement inhibition [PDF]
Journal of Biological ChemistryMany hematophagous organisms secrete inhibitors of the coagulation and complement systems as constituents of their salivary fluid. Whereas previous studies on salivary gland extracts from the sandfly Lutzomyia longipalpis identified SALO (salivary ...
Huiquan Duan +2 more
exaly +3 more sources
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. [PDF]
PLoS Pathogens, 2016 Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system.
Brandon L Garcia +4 more
doaj +7 more sources
Increased Serum Signal Peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial Growth Factor Domain-Containing Protein-1 May Have a Role in the Pathophysiology of Late-Onset Fetal Growth Restriction [PDF]
Diagnostics (Basel)Background/Objective: Fetal growth restriction (FGR) is a condition in which the fetus fails to grow as expected for gestational age, and its growth is restricted.
Gulseren Dinc +2 more
semanticscholar +2 more sources
Comment on "Could signal peptide complement C1r/C1s, Uegf, and Bmp1, and epidermal growth factor-containing protein 1 be a therapeutic target in the pathogenesis of preeclampsia?" [PDF]
Rev Assoc Med Bras (1992)We have read with great interest the article entitled “Could signal peptide complement C1r/C1s ...
Che-Yuan Cheng, Yanxiang Wang
semanticscholar +2 more sources