Results 1 to 10 of about 5,370 (126)

Plasma Extracellular Vesicles‐Derived Complement Proteins as Biomarkers of Sarcopenia Progression in Longitudinal Cohorts [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Sarcopenia is characterized by progressive loss of muscle mass, strength and physical performance, yet current diagnostic tools are limited for practical and longitudinal monitoring.
Ji Yeon Kim, Sung Hye Kong, Dohyun Han, Tae‐Hwan Gil, Hyeon Soo Kim, Miji Kim, Jin Hee Kim, Seung Shin Park, Seong‐Jun Park, Hak Chul Jhang, Chang Won Won, Ok Hee Jeon   +11 more
doaj   +3 more sources

Tumour cell-intrinsic complement C1r and C1s regulate cancer cell fitness and shape the immune microenvironment in triple-negative breast cancer [PDF]

Cellular and Molecular Life Sciences
Emerging evidence positions tumour cell-intrinsic complement proteins as regulators of cancer cell behaviour and immune crosstalk, yet their role in triple-negative breast cancer (TNBC) remains undefined.
Andrea Minery, Maria Radanova, Lou Segarra, Julie Peliconi, Alaeddine Redissi, Emma Fleury, Idris Boudhabhay, Lubka T. Roumenina   +7 more
doaj   +2 more sources

A non-complement role for C1R rewires integrin and death-receptor signaling to drive renal cancer metastasis [PDF]

Molecular Cancer
Background Metastasis is the leading cause of death in clear cell renal cell carcinoma (ccRCC) patients. Anoikis, a form of programmed cell death induced by the loss of cell-extracellular matrix interactions, is a critical factor in hindering metastasis.
Haotian Wei, Shenglong Li, Shimiao Zhu, Chenglong Xu, Yue Wang, Zhaochen Li, Yujing Guan, Jiahang Li, Runze Jiang, Xianglian Ge, Tailong Yi, Xing Xu, Yang Xie, Jing Tian, Yingzhe Piao, Ping Zhang, Changyi Quan, Xun Jin   +17 more
doaj   +2 more sources

Complement Components C1r and C8 Serve as Potential Inflammatory Biomarkers for Coronary Heart Disease Severity: The Mediating Role of C-Reactive Protein [PDF]

Journal of Inflammation Research
Xia Feng,1– 4,* Xiaoting Jiang,1– 4,* Shaolin Gong,1– 4,* Wen Liu,1– 4 Qiong Yan,1 Hongmei Qi,1 Ling Yu,1 Xiang Wang,1– 4 Xiaoping Peng1– 4 1Department of Cardiology, The First Affiliated Hospital, Jiangxi Medical College ...
Feng X, Jiang X, Gong S, Liu W, Yan Q, Qi H, Yu L, Wang X, Peng X   +8 more
doaj   +2 more sources

C1R Mutations Trigger Constitutive Complement 1 Activation in Periodontal Ehlers-Danlos Syndrome

Frontiers in Immunology, 2019
Heterozygous missense or in-frame insertion/deletion mutations in complement 1 subunits C1r and C1s cause periodontal Ehlers-Danlos Syndrome (pEDS), a specific EDS subtype characterized by early severe periodontal destruction and connective tissue ...
Rebekka Gröbner, Ines Kapferer-Seebacher, Albert Amberger, Rita Redolfi, Fabien Dalonneau, Erik Björck, Erik Björck, Di Milnes, Isabelle Bally, Veronique Rossi, Nicole Thielens, Heribert Stoiber, Christine Gaboriaud, Johannes Zschocke   +13 more
doaj   +3 more sources

Tumor Cell-Derived Complement Component C1r Acts as a Prognostic Biomarker and Promotes Esophageal Squamous Cell Carcinoma Progression

Frontiers in Bioscience-Landmark
Background: Mounting evidence indicates that complement components play a crucial role in cancer progression. Recent findings indicate that certain complement components display a significant rise in expression within esophageal squamous cell carcinoma ...
Maolin Tang, Shisheng Zhao, Ling Ren, Qianqian Li, Li Li, Chaoli Wang, Chunmei Meng, Yuling Chen, Weimin Hu   +8 more
doaj   +3 more sources

BBK32 attenuates antibody-dependent complement-mediated killing of infectious Borreliella burgdorferi isolates. [PDF]

PLoS Pathogens
Borreliella burgdorferi, the causative agent of Lyme disease, has evolved unique complement evasion proteins that promote its ability to establish and maintain infection in mammalian hosts. Among these is B.
Alexandra D Powell-Pierce, Charles E Booth, Payton G Smith, Brittany L Shapiro, Shannon S Allen, Brandon L Garcia, Jon T Skare   +6 more
doaj   +2 more sources

Production and characterization of gigastasin, a leech-derived inhibitor of complement and coagulation pathways [PDF]

Scientific Reports
The complement and coagulation systems protect against injury and infection, but ill-controlled activation may cause clinical complications. Despite their efficacy in defined indications, approved complement and coagulation inhibitors remain poorly ...
Aleksandra Blagojevic, Peter Rüthemann, Kevin Widmer, Marco Mannes, Dilara Caglar, Mateja Tiric, Mathew Ebin Sovichan, Richard B. Pouw, Said Rabbani, Markus Huber-Lang, Daniel Ricklin   +10 more
doaj   +2 more sources

Plasma Proteomic Signatures of Pediatric Sepsis Reveal Persistent Inflammation and Phase‐Specific Biomarkers [PDF]

FASEB BioAdvances
Sepsis remains a leading cause of pediatric morbidity and mortality, yet its molecular underpinnings are poorly understood. Here, we performed mass spectrometry–based plasma proteomics and cytokine profiling in pediatric sepsis patients at the acute ...
Fahd Alhamdan, Yi‐Cheng Sin, Erik Malm, Hanna Van Pelt, Samuel Kim, LeeAnn Higgins, Yue Chen, Koichi Yuki   +7 more
doaj   +2 more sources

Complement C1r serine protease contributes to kidney fibrosis

American Journal of Physiology - Renal Physiology, 2019
Sai Vineela Bontha, Nicole Thielens, Sandhya Xavier   +2 more
exaly   +2 more sources