Results 11 to 20 of about 796,318 (197)

Could signal peptide complement C1r/C1s, Uegf, and Bmp1, and epidermal growth factor-containing protein 1 be a therapeutic target in the pathogenesis of preeclampsia? [PDF]

Rev Assoc Med Bras (1992)
SUMMARY OBJECTIVE: Determination of biomolecules that play a role in the etiopathogenesis of preeclampsia and their application as therapeutic targets may increase surveillance in this patient group.
K. Toprak, Zafer Yıldız, S. Akdemir, Kamil Esen, Rahime Kada Düken   +4 more
semanticscholar   +2 more sources

The diagnostic significance of signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein-1 levels in pulmonary embolism [PDF]

Ann Thorac Med, 2016
Background: Pulmonary embolism (PE) is a common and potentially life-threatening disorder. Patients with PE often have nonspecific symptoms, and the diagnosis is often delayed.
N. Dirican, A. Duman, G. Saglam, Akif Arslan, O. Ozturk, Şule Atalay, A. Bircan, A. Akkaya, Munire Cakir   +8 more
semanticscholar   +2 more sources

The Relationship between Complement Components C1R and C5 Gene Polymorphism and the Values of Blood Indices in Suckling Piglets

Genes, 2023
The main mechanism of innate immunity is the complement system. Its components include the protein products of the C1R and C5 genes, which are involved in the classical activation pathway as well as the inflammatory and cytolytic immune responses ...
Hanna Szymanska, Ewa Dzika
exaly   +2 more sources

Conformational dynamics of complement protease C1r inhibitor proteins from Lyme disease– and relapsing fever–causing spirochetes

Journal of Biological Chemistry, 2023
Borrelial pathogens are vector-borne etiological agents known to cause Lyme disease, relapsing fever, and Borrelia miyamotoi disease. These spirochetes each encode several surface-localized lipoproteins that bind components of the human complement system
Sourav Roy, Charles E Booth, Alexandra D Powell-Pierce   +2 more
exaly   +2 more sources

Autoantibodies against Complement Classical Pathway Components C1q, C1r, C1s and C1-Inh in Patients with Lupus Nephritis

International Journal of Molecular Sciences, 2022
Autoantibodies against the complement component C1q (anti-C1q) are among the main biomarkers in lupus nephritis (LN) known to contribute to renal injury.
Maria Radanova, Vasil Vasilev, Uday Kishore   +2 more
exaly   +2 more sources

A structural basis for inhibition of the complement initiator protease C1r by Lyme disease spirochetes [PDF]

The Journal of Immunology, 2021
Key Points We provide a structural basis for inhibition of complement by a bacterial protein. This study improves our knowledge of how pathogens evade early complement steps.
Ryan J. Garrigues, Alexandra D. Powell-Pierce, M. Hammel, J. Skare, B. Garcia   +4 more
semanticscholar   +4 more sources

Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement [PDF]

The American Journal of Human Genetics, 2016
Periodontal Ehlers-Danlos syndrome (pEDS) is an autosomal-dominant disorder characterized by early-onset periodontitis leading to premature loss of teeth, joint hypermobility, and mild skin findings.
I. Kapferer-Seebacher, M. Pepin, Roland Werner, T. Aitman, A. Nordgren, H. Stoiber, N. Thielens, C. Gaboriaud, A. Amberger, A. Schossig, R. Gruber, C. Giunta, M. Bamshad, E. Björck, Christina Chen, D. Chitayat, M. Dorschner, Marcus Schmitt-Egenolf, Christopher J. Hale, D. Hanna, H. Hennies, Irene Heiss-Kisielewsky, A. Lindstrand, P. Lundberg, A. Mitchell, D. Nickerson, E. Reinstein, M. Rohrbach, N. Romani, M. Schmuth, R. Silver, F. Taylan, A. Vandersteen, J. Vandrovcova, R. Weerakkody, Margaret Yang, F. Pope, Kirk Zoltan Joszef Herbert Hady James K. Charles N. Usc Aleck Banki Dudas Dumfahrt Haririan Hartsfield Kag, K. Aleck, Z. Bánki, J. Dudas, H. Dumfahrt, H. Haririan, J. Hartsfield, C. Kagen, Uschi Lindert, T. Meitinger, W. Posch, C. Pritz, D. Ross, R. Schroer, G. Wick, R. Wildin, D. Wilflingseder, P. Byers, J. Zschocke   +55 more
semanticscholar   +14 more sources

Corrigendum: C1R Mutations Trigger Constitutive Complement 1 Activation in Periodontal Ehlers-Danlos Syndrome

Frontiers in Immunology, 2019
[This corrects the article DOI: 10.3389/fimmu.2019.02537.].
Rebekka Gröbner, Ines Kapferer-Seebacher, Albert Amberger, Rita Redolfi, Fabien Dalonneau, Erik Björck, Erik Björck, Di Milnes, Isabelle Bally, Veronique Rossi, Nicole Thielens, Heribert Stoiber, Christine Gaboriaud, Johannes Zschocke   +13 more
doaj   +2 more sources

Structure of the C1r–C1s interaction of the C1 complex of complement activation [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance C1 is a large complex that triggers the destruction of invading pathogens via lysis or by stimulation of innate and adaptive immune processes.
Jamal O M Almitairi, Umakhanth Venkatraman Girija, C. Furze, X. Simpson-Gray, Farah Badakshi, J. E. Marshall, W. Schwaeble, D. Mitchell, P. Moody, R. Wallis   +9 more
semanticscholar   +5 more sources

Diagnostic value of signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 on serum and tissue samples in non-small cell lung cancer. [PDF]

Turk Gogus Kalp Damar Cerrahisi Derg, 2018
S. Gürz, B. Çelik, A. Menteşe, Diler Us Altay   +3 more
semanticscholar   +2 more sources