Results 31 to 40 of about 375,488 (189)
Complement C1s as a diagnostic marker and therapeutic target: Progress and propective
Frontiers in Immunology, 2022 The molecules of the complement system connect the effectors of innate and adaptive immunity and play critical roles in maintaining homeostasis. Among them, the C1 complex, composed of C1q, C1r, and C1s (C1qr2s2), is the initiator of the classical ...
Jun Ye +4 more
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The axis of complement C1 and nucleolus in antinuclear autoimmunity
Frontiers in Immunology, 2023 Antinuclear autoantibodies (ANA) are heterogeneous self-reactive antibodies that target the chromatin network, the speckled, the nucleoli, and other nuclear regions.
Shan Wu +15 more
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Characteristics of complement subcomponents C1r and C1s synthesized by Hep G2 cells [PDF]
Biochemical Journal, 1986 The association and activation states of complement subcomponents C1r and C1s biosynthesized by Hep G2 cells were studied. C1r and C1s are secreted in stoichiometric amounts; in the presence of Ca2+ they are associated in a complex that sediments similarly to plasma C1r2-C1s2.
A, Reboul, J C, Bensa, M G, Colomb
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Characterization and functional analysis of mouse Ficolin B [PDF]
, 2012 The innate immune system contributes day by day to the elimination of invading pathogens. The lectin pathway of the complement system is initiated when mannose-binding-lectin (MBL) or ficolins interact with MASP-2.
Hunold, Katja
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Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein [PDF]
Proceedings of the National Academy of Sciences, 2004 Many secretory proteins are synthesized as proforms that become biologically active through a proteolytic cleavage in the trans-Golgi complex or at a later stage in the secretory pathway. Haptoglobin (Hp) is unusual in that it is cleaved in the endoplasmic reticulum before it enters the Golgi.
Krzysztof B, Wicher, Erik, Fries
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PLoS Pathogens, 2019 The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r.
Jialei Xie +5 more
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Assembly and Enzymatic Properties of the Catalytic Domain of Human Complement Protease C1r [PDF]
Journal of Biological Chemistry, 2001 The catalytic properties of C1r, the protease that mediates activation of the C1 complex of complement, are mediated by its C-terminal region, comprising two complement control protein (CCP) modules followed by a serine protease (SP) domain. Baculovirus-mediated expression was used to produce fragments containing the SP domain and either 2 CCP modules (
M, Lacroix +7 more
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Biomolecules, 2021 We report an extremely rare case of combined classical and periodontal Ehlers−Danlos syndrome (EDS) with early severe periodontitis and a generalized lack of attached gingiva.
Friedrich Stock +6 more
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Frontiers in Cardiovascular Medicine, 2022 BackgroundThe pathophysiological mechanisms of intermittent claudication (IC) progression to chronic limb-threatening ischemia (CLTI) are still vague and which of patients with IC will become CLTI are unknown.
Ziping Yao +6 more
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Frontiers in Immunology, 2016 The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune complex-mediated ...
Katherine eLintner +7 more
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