Results 31 to 40 of about 796,318 (197)

Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery

Molecules, 2020
The initiating protease of the complement classical pathway, C1r, represents an upstream and pathway-specific intervention point for complement-related autoimmune and inflammatory diseases.
Blake R. Rushing, Denise L. Rohlik, Sourav Roy, D. Andrew Skaff, Brandon L. Garcia   +4 more
doaj   +1 more source

The role of complement in the clinical course of hepatocellular carcinoma

Immunity, Inflammation and Disease, 2022
Background The complement system, an innate immune system, may either play an antitumor role, or promote tumorigenesis and cancer progression in different kinds of cancer. The function of complement in hepatocellular carcinoma (HCC) is unclear.
Xinye Qian, Zhoujing Yang, Lu Gao, Yipiao Liu, Jun Yan   +4 more
doaj   +1 more source

Degradation of collagen I by activated C1s in periodontal Ehlers-Danlos Syndrome

Frontiers in Immunology, 2023
Periodontal Ehlers-Danlos syndrome (pEDS) is an autosomal dominant disorder characterized by early-onset periodontitis leading to premature loss of teeth, lack of attached gingiva and thin and fragile gums leading to gingival recession. Connective tissue
Albert Amberger, Johanna Pertoll, Pia Traunfellner, Ines Kapferer-Seebacher, Heribert Stoiber, Lars Klimaschewski, Nicole Thielens, Christine Gaboriaud, Johannes Zschocke   +8 more
doaj   +1 more source

Novel scabies mite serpins inhibit the three pathways of the human complement system. [PDF]

PLoS ONE, 2012
Scabies is a parasitic infestation of the skin by the mite Sarcoptes scabiei that causes significant morbidity worldwide, in particular within socially disadvantaged populations. In order to identify mechanisms that enable the scabies mite to evade human
Angela Mika, Simone L Reynolds, Frida C Mohlin, Charlene Willis, Pearl M Swe, Darren A Pickering, Vanja Halilovic, Lakshmi C Wijeyewickrema, Robert N Pike, Anna M Blom, David J Kemp, Katja Fischer   +11 more
doaj   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H., Mitchell, Daniel A., Schmid, Ralf, Schwaeble, Wilhelm J., Wallis, Russell   +4 more
core   +1 more source

Multifocal periapical cemental dysplasia in periodontal Ehlers–Danlos syndrome combined with leukoencephalopathy in the mutation of c.890G > a, G297D [pEDS]

Clinical Case Reports, 2022
Periodontal Ehlers‐Danlos syndrome (pEDS) is a rare disorder caused by heterozygous mutations in complement 1 subunit genes C1R and C1S. To date, 148 cases have been described in the literature.We describe a case of a suspected de novo‐mutation of pEDS ...
Manfred Nilius, Minou Helene Nilius, Charlotte Müller, Guenter Lauer, Koch Berit, Kohlhaas Marcus   +5 more
doaj   +1 more source

No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice

Vascular Biology, 2022
Marfan syndrome (MFS) is a connective tissue disorder causing aortic aneurysm formation. Currently, only prophylactic aortic surgery and blood pressure-lowering drugs are available to reduce the risk of aortic rupture.
Stijntje Hibender, Siyu Li, Alex V Postma, Myrthe E Hoogeland, Denise Klaver, Richard B Pouw, Hans W Niessen, Antoine HG Driessen, David R Koolbergen, Carlie JM de Vries, Marieke JH Baars, Arjan C Houweling, Paul A Krijnen, Vivian de Waard   +13 more
doaj   +1 more source

Complement C1s as a diagnostic marker and therapeutic target: Progress and propective

Frontiers in Immunology, 2022
The molecules of the complement system connect the effectors of innate and adaptive immunity and play critical roles in maintaining homeostasis. Among them, the C1 complex, composed of C1q, C1r, and C1s (C1qr2s2), is the initiator of the classical ...
Jun Ye, Jun Ye, Peng Yang, Yili Yang, Sheng Xia   +4 more
doaj   +1 more source

Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937 [PDF]

, 2016
In order to evaluate probiotic strains applicable for the beneficial immunomodulation of the porcine gut (immunobiotics), we previously developed a porcine intestinal epitheliocyte cell line (PIE cells).
Albarracín, Leonardo Miguel, Aso, Hisashi, Ikeda-Ohtsubo, Wakako, Kanmani, Paulraj, Kano, Hiroshi, Kitazawa, Haruki, Kobayashi, Hisakazu, Kober, Humayun A.K.M., Makino, Seiya, Nochi, Tomonori, Ohkawara, Sou, Saito, Tadao, Sato, Nana, Suda, Yoshihito, Villena, Julio Cesar   +14 more
core   +1 more source

The axis of complement C1 and nucleolus in antinuclear autoimmunity

Frontiers in Immunology, 2023
Antinuclear autoantibodies (ANA) are heterogeneous self-reactive antibodies that target the chromatin network, the speckled, the nucleoli, and other nuclear regions.
Shan Wu, Shan Wu, Junjie Chen, Junjie Chen, Boon Heng Dennis Teo, Boon Heng Dennis Teo, Seng Yin Kelly Wee, Seng Yin Kelly Wee, Ming Hui Millie Wong, Ming Hui Millie Wong, Jianzhou Cui, Jinmiao Chen, Jinmiao Chen, Khai Pang Leong, Jinhua Lu, Jinhua Lu   +15 more
doaj   +1 more source