Results 41 to 50 of about 375,488 (189)

Changes in Expression of Complement Components in the Ovine Spleen during Early Pregnancy

Animals, 2021
During early gestation in humans, complement regulation is essential for normal fetal growth. It is supposed that a complement pathway participates in maternal splenic immune regulation at the early stage of gestation in ewes.
Ling Yang, Luyu Wang, Jiaxuan Wu, Haichao Wang, Gengxin Yang, Leying Zhang   +5 more
doaj   +1 more source

Autoantibodies against Complement Classical Pathway Components C1q, C1r, C1s and C1-Inh in Patients with Lupus Nephritis [PDF]

, 2022
Autoantibodies against the complement component C1q (anti-C1q) are among the main biomarkers in lupus nephritis (LN) known to contribute to renal injury.
Kosturkova, M, Radanova, M, Lubka Roumenina, Mihaylova, G, Vasilev, Vasil, Vasilev, V, Roumenina, L, Radanova, Maria, Vasil Vasilev, Kishore, U, Kosturkova, Mariya, Kishore, Uday, Maria Radanova, Mariya Kosturkova, Roumenina, Lubka, Mihaylova, Galya, Galya Mihaylova, Uday Kishore   +17 more
core   +1 more source

Complement components C1q, C1r/C1s, and C1inh in rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 1995
AbstractObjective. To analyze the synovial site and the cell types expressing C1q, C1r/C1s, and C1–esterase inhibitor (C1INH) and to characterize newly synthesized C1q in patients with rheumatoid arthritis (RA).Methods. Tissue and primary cell cultures of synovium from RA patients were analyzed for C1q, C1r/C1s, and C1INH by Northern blotting, in situ ...
Susanne Breitner, Stephan Störkel, Wolfgang Reichel, Michael Loos   +3 more
openaire   +1 more source

Functional Analysis of Two Divergent C4 Isotypes in the Classical and Lectin Pathways of Complement Activation in the Common Carp (Cyprinus carpio)

Journal of Marine Science and Engineering, 2023
In the evolution of the complement system, a major humoral innate immune factor, the existence of multiple isotypes of the complement components is considered as a key strategy to enhance innate immune defense. Complement C4 is also diversified in a wide
Rosli Nehlah, Akira Yamamoto, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao   +4 more
doaj   +1 more source

Development of small-molecule inhibitors of the initiating proteases, C1r and C1s, of the classical complement pathway

, 2023
Complement is a proteolytic cascade that upon activation plays a key effector role in the innate immune system and acts to prime the adaptive immune response.
Rohlik, Denise L, NC DOCKS at East Carolina University   +1 more
core  

Peptide inhibitor of complement C1 (PIC1), a novel suppressor of classical pathway activation: mechanistic studies and clinical potential

Frontiers in Immunology, 2014
The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses as well as an essential homeostatic role in the clearance of damaged self-antigens.
Julia A Sharp, Pamela H. Whitley, Kenji M. Cunnion, Kenji M. Cunnion, Neel Kumar Krishna, Neel Kumar Krishna   +5 more
doaj   +1 more source

Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface.

PLoS Pathogens, 2017
Whooping cough, or pertussis, is a contagious disease of the respiratory tract that is re-emerging worldwide despite high vaccination coverage. The causative agent of this disease is the Gram-negative Bordetella pertussis. Knowledge on complement evasion
Elise S Hovingh, Bryan van den Broek, Betsy Kuipers, Elena Pinelli, Suzan H M Rooijakkers, Ilse Jongerius   +5 more
doaj   +1 more source

Cell surface expression and function of the macromolecular C1 complex on the surface of human monocytes

Frontiers in Immunology, 2012
The synthesis of the subunits of the C1 complex (C1q, C1s, C1r), and its regulator C1 inhibitor (C1-Inh) by human monocytes has been previously established. However, surface expression of these molecules by monocytes has not been shown.
Kinga K Hosszu, Alisa eValentino, Yan eJi, Mara eMatkovic, Lina ePednekar, Nina eRehage, Nithin eTumma, Ellinor I.E. Peerschke, Berhane eGhebrehiwet   +8 more
doaj   +1 more source

Unifying Composition and Process Design: A Heterogeneous Graph Neural Network for Discovering High‐Performance Cu Alloys

Advanced Science, EarlyView.
By overcoming the fixed‐path limitations of conventional machine learning, a heterogeneous graph neural network fundamentally reconstructs material data representation. Integrating variable processing sequences with intrinsic elemental features, this framework enables exploratory optimization across high‐dimensional spaces.
Jie Yin, Qian Lei, Wei Yan, Yue Li, Tong Xie, Shuang Zhou, Chong Wang, Bram Hoex, Qiang Long, Caoyang Jiang, Min Song, Zhou Li, Zhangwei Wang   +12 more
wiley   +1 more source

Two Different Missense C1S Mutations, Associated to Periodontal Ehlers-Danlos Syndrome, Lead to Identical Molecular Outcomes

Frontiers in Immunology, 2019
Ehlers-Danlos syndromes (EDS) are clinically and genetically heterogeneous disorders characterized by soft connective tissue alteration like joint hypermobility and skin hyper-extensibility. We previously identified heterozygous missense mutations in the
Isabelle Bally, Fabien Dalonneau, Anne Chouquet, Rebekka Gröbner, Albert Amberger, Ines Kapferer-Seebacher, Heribert Stoiber, Johannes Zschocke, Nicole M. Thielens, Véronique Rossi, Christine Gaboriaud   +10 more
doaj   +1 more source