Results 41 to 50 of about 796,318 (197)

The metric space of geodesic laminations on a surface II: small surfaces [PDF]

open access: yes, 2005
We continue our investigation of the space of geodesic laminations on a surface, endowed with the Hausdorff topology. We determine the topology of this space for the once-punctured torus and the 4-times-punctured sphere.
Bonahon, Francis, Zhu, Xiaodong
core   +2 more sources

Therapeutic Intervention of Neuroinflammatory Alzheimer Disease Model by Inhibition of Classical Complement Pathway with the Use of Anti-C1r Loaded Exosomes

open access: yesResearch Square, 2023
Alzheimer’s disease (AD) is a complex neurodegenerative disease associated with memory decline, cognitive impairment, amyloid plaque formation and tau tangles. Neuroinflammation has been shown to be a precursor to apparent amyloid plaque accumulation and
Terjahna Richards   +5 more
semanticscholar   +1 more source

Evaluation of the immunomodulatory activities of the probiotic strain lactobacillus fermentum UCO-979C [PDF]

open access: yes, 2019
Lactobacillus fermentum UCO-979C, a strain isolated from a human stomach, was previously characterized by its potential probiotic properties. The UCO-979C strain displayed the ability to beneficially regulate the innate immune response triggered by ...
Alvarez, Gladis Susana   +11 more
core   +1 more source

Polynomial Stability of Semigroups Generated by Operator Matrices [PDF]

open access: yes, 2013
In this paper we study the stability properties of strongly continuous semigroups generated by block operator matrices. We consider triangular and full operator matrices whose diagonal operator blocks generate polynomially stable semigroups.
Paunonen, Lassi
core   +1 more source

Assembly and Enzymatic Properties of the Catalytic Domain of Human Complement Protease C1r [PDF]

open access: yesJournal of Biological Chemistry, 2001
The catalytic properties of C1r, the protease that mediates activation of the C1 complex of complement, are mediated by its C-terminal region, comprising two complement control protein (CCP) modules followed by a serine protease (SP) domain. Baculovirus-mediated expression was used to produce fragments containing the SP domain and either 2 CCP modules (
M, Lacroix   +7 more
openaire   +2 more sources

Prepubertal Periodontitis in a Patient with Combined Classical and Periodontal Ehlers–Danlos Syndrome

open access: yesBiomolecules, 2021
We report an extremely rare case of combined classical and periodontal Ehlers−Danlos syndrome (EDS) with early severe periodontitis and a generalized lack of attached gingiva.
Friedrich Stock   +6 more
doaj   +1 more source

Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes.

open access: yesPLoS Pathogens, 2019
The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r.
Jialei Xie   +5 more
doaj   +1 more source

Characteristics of complement subcomponents C1r and C1s synthesized by Hep G2 cells [PDF]

open access: yesBiochemical Journal, 1986
The association and activation states of complement subcomponents C1r and C1s biosynthesized by Hep G2 cells were studied. C1r and C1s are secreted in stoichiometric amounts; in the presence of Ca2+ they are associated in a complex that sediments similarly to plasma C1r2-C1s2.
A, Reboul, J C, Bensa, M G, Colomb
openaire   +2 more sources

Subunits of C1Q Are Associated With the Progression of Intermittent Claudication to Chronic Limb-Threatening Ischemia

open access: yesFrontiers in Cardiovascular Medicine, 2022
BackgroundThe pathophysiological mechanisms of intermittent claudication (IC) progression to chronic limb-threatening ischemia (CLTI) are still vague and which of patients with IC will become CLTI are unknown.
Ziping Yao   +6 more
doaj   +1 more source

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases

open access: yesFrontiers in Immunology, 2016
The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune complex-mediated ...
Katherine eLintner   +7 more
doaj   +1 more source

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