Results 21 to 30 of about 796,318 (197)

The complement system contributes to the immunosuppressive microenvironment of uveal melanoma [PDF]

Journal of Translational Medicine
Background Uveal melanoma (UM) is a rare disease, but the most common intraocular malignancy in adults, with incidence rates in Europe ranging from 1.3 to 8.6 cases per million annually.
Iryna Zherka, Helen Kalirai, Dominika Majorova, Sarah E. Coupland, Monica M. Olcina   +4 more
doaj   +2 more sources

Plasma Proteomic Signatures of Pediatric Sepsis Reveal Persistent Inflammation and Phase‐Specific Biomarkers [PDF]

FASEB BioAdvances
Sepsis remains a leading cause of pediatric morbidity and mortality, yet its molecular underpinnings are poorly understood. Here, we performed mass spectrometry–based plasma proteomics and cytokine profiling in pediatric sepsis patients at the acute ...
Fahd Alhamdan, Yi‐Cheng Sin, Erik Malm, Hanna Van Pelt, Samuel Kim, LeeAnn Higgins, Yue Chen, Koichi Yuki   +7 more
doaj   +2 more sources

Proteomics identifies complement protein signatures in patients with primary biliary cholangitis [PDF]

European Journal of Medical Research
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease lacking reliable biomarkers for diagnosis or prognosis. To identify plasma complement biomarkers that improve diagnosis and prognosis of PBC.
Xiaolin Ma, Hang Dong, Junming Han, Ming Han, Teng Zhang, Meng Zhou, Xiude Fan, Luna Liu, Zhen Wang   +8 more
doaj   +2 more sources

Complement activation in tumor microenvironment after neoadjuvant therapy and its impact on pancreatic cancer outcomes

npj Precision Oncology
Neoadjuvant therapy (NAT) is increasingly being used for pancreatic ductal adenocarcinoma (PDAC). This study investigates how NAT differentially impacts PDAC’s carcinoma cells and the tumor microenvironment (TME).
Xiaofei Zhang, Ruoxin Lan, Yongjun Liu, Venu G. Pillarisetty, Danting Li, Chaohui L. Zhao, Suparna A. Sarkar, Weiguo Liu, Iman Hanna, Mala Gupta, Cristina Hajdu, Jonathan Melamed, Michael Shusterman, Jessica Widmer, John Allendorf, Yao-Zhong Liu   +15 more
doaj   +2 more sources

Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein. [PDF]

Proceedings of the National Academy of Sciences, 2004
Many secretory proteins are synthesized as proforms that become biologically active through a proteolytic cleavage in the trans-Golgi complex or at a later stage in the secretory pathway. Haptoglobin (Hp) is unusual in that it is cleaved in the endoplasmic reticulum before it enters the Golgi.
K. Wicher, E. Fries
semanticscholar   +3 more sources

Exon structure of the gene encoding the human mannose-binding protein-associated serine protease light chain: comparison with complement C1r and C1s genes

International Immunology, 1996
Teizo Fujita
exaly   +2 more sources

Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies

Scientific Reports
Increasing evidence points toward an essential role for complement activation in the pathogenesis of diabetic kidney disease (DKD). However, the precise molecular mechanisms remain unclear, and the pathway predominantly contributing to complement ...
Yang Yang, Ying Zhang, Yuan Li, Xinjin Zhou, Kazuho Honda, Dedong Kang, Muxi Wang, Jing-Hua Yang, Zongping Xia, Yuan Wei, Lu Liu, Ruimin Hu, Takashi Takaki, Guolan Xing   +13 more
doaj   +2 more sources

Complement pathway dysregulation and astrocyte alterations in Down syndrome: evidence from postmortem brain tissue and iPSC-derived astrocytes [PDF]

Acta Neuropathologica Communications
Background Down syndrome (DS), or trisomy 21 (T21), resulting from an extra copy of chromosome 21, occurs in 1 in 700–1,000 live births. Neuroinflammation is increasingly recognized as a critical contributor to DS neuropathology, although its underlying ...
André Luíz Teles e Silva, Pedro Henrique Prado de Oliveira, Bruno Yukio Yokota-Moreno, Jéssica da Silva Fausto, Jonatan Peña Avila, Helder I. Nakaya, Andréa Laurato Sertié, Bruna Lancia Zampieri   +7 more
doaj   +2 more sources

Borrelia miyamotoi FbpA and FbpB Are Immunomodulatory Outer Surface Lipoproteins With Distinct Structures and Functions

Frontiers in Immunology, 2022
Pathogens that traffic in the blood of their hosts must employ mechanisms to evade the host innate immune system, including the complement cascade. The Lyme disease spirochete, Borreliella burgdorferi, has evolved numerous outer membrane lipoproteins ...
Charles E. Booth, Alexandra D. Powell-Pierce, Jon T. Skare, Brandon L. Garcia   +3 more
doaj   +1 more source

A novel human complement-related protein, C1r-like protease (C1r-LP) activates the early components of the classical complement pathway [PDF]

Molecular Immunology, 2007
The availability of the human genome sequence allowed us to identify a human complement-related, C1r-like protease gene (c1r-LP) located 2 kb centromeric of the C1r gene (c1r). Compared with c1r, c1r-LP carries a large deletion corresponding to exons 4–8 of c1r.
Yuanyuan Xu, Christina Ligoudistianou, John E. Volanakis   +2 more
  +6 more sources