Complement C1s as a diagnostic marker and therapeutic target: Progress and propective
Frontiers in Immunology, 2022 The molecules of the complement system connect the effectors of innate and adaptive immunity and play critical roles in maintaining homeostasis. Among them, the C1 complex, composed of C1q, C1r, and C1s (C1qr2s2), is the initiator of the classical ...
Yili Yang
exaly +3 more sources
C1s protects cutaneous squamous carcinoma cells from TRAIL-induced apoptosis [PDF]
OncogenesisCutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The prognosis of the metastatic cSCC is poor, and there are no established biomarkers to predict metastasis risk, nor specific targeted therapies for advanced or ...
Maria Salmela +7 more
doaj +2 more sources
Tumour cell-intrinsic complement C1r and C1s regulate cancer cell fitness and shape the immune microenvironment in triple-negative breast cancer [PDF]
Cellular and Molecular Life SciencesEmerging evidence positions tumour cell-intrinsic complement proteins as regulators of cancer cell behaviour and immune crosstalk, yet their role in triple-negative breast cancer (TNBC) remains undefined.
Andrea Minery +7 more
doaj +2 more sources
Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement functionResearch in context [PDF]
EBioMedicineSummary: Background: Antibody drugs blocking the complement classical pathway (CP) often require frequent intravenous administration to overcome the high abundance or rapid turnover of complement proteins.
Adrian W.S. Ho +27 more
doaj +2 more sources
The expression and biological role of complement C1s in esophageal squamous cell carcinoma
Open Life SciencesThe present work focused on investigating the role of the altered expression of complement C1s in proliferation and apoptosis of esophageal squamous cell carcinoma (ESCC) cells and explore its biological functions in ESCC, so as to lay a theoretical ...
Ge Ruomu +5 more
exaly +2 more sources
Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches
Molecules, 2019 The complement system is associated with various diseases such as inflammation or auto-immune diseases. Complement-targeted drugs could provide novel therapeutic intervention against the above diseases.
Balázs Balogh +2 more
exaly +3 more sources
C1s targeting antibodies inhibit the growth of cutaneous squamous carcinoma cells
Scientific ReportsCutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The incidence of cSCC is increasing globally and the prognosis of metastatic disease is poor.
Pilvi Riihilä +2 more
exaly +2 more sources
The Role of Exchange Energy in Modeling Core-Electron Binding Energies of Strongly Polar Bonds [PDF]
MoleculesAccurate determination of carbon core-electron binding energies (C1s CEBEs) is crucial for X-ray photoelectron spectroscopy (XPS) assignments and predictive computational modeling.
Feng Wang, Delano P. Chong
doaj +2 more sources
Quantitative fluorescence resonance energy transfer-based immunoassay for activated complement C1s
Frontiers in Immunology, 2023 ObjectivesC1s activation is associated with the pathogenesis of various diseases, indicating the potential value of C1s activation detection in clinic.
Jun Ye +5 more
doaj +1 more source
HMGB1 cleavage by complement C1s and its potent anti-inflammatory product
Frontiers in Immunology, 2023 Complement C1s association with the pathogenesis of several diseases cannot be simply explained only by considering its main role in activating the classical complement pathway.
Marie Lorvellec +11 more
doaj +1 more source