Results 1 to 10 of about 51,957 (286)

Complement C1s as a diagnostic marker and therapeutic target: Progress and propective

Frontiers in Immunology, 2022
The molecules of the complement system connect the effectors of innate and adaptive immunity and play critical roles in maintaining homeostasis. Among them, the C1 complex, composed of C1q, C1r, and C1s (C1qr2s2), is the initiator of the classical ...
Jun Ye, Jun Ye, Peng Yang, Yili Yang, Sheng Xia   +4 more
exaly   +3 more sources

C1s protects cutaneous squamous carcinoma cells from TRAIL-induced apoptosis [PDF]

Oncogenesis
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The prognosis of the metastatic cSCC is poor, and there are no established biomarkers to predict metastasis risk, nor specific targeted therapies for advanced or ...
Maria Salmela, Liisa Nissinen, Pekka Rappu, Kristina Viiklepp, Marjaana Ojalill, Jyrki Heino, Pilvi Riihilä, Veli-Matti Kähäri   +7 more
doaj   +2 more sources

Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement functionResearch in context [PDF]

EBioMedicine
Summary: Background: Antibody drugs blocking the complement classical pathway (CP) often require frequent intravenous administration to overcome the high abundance or rapid turnover of complement proteins.
Adrian W.S. Ho, Taku Fukuzawa, Hikaru Koga, Ken Ohmine, Hiroki Kawauchi, Masaru Muraoka, Yuri Ikuta, Garvita Gupta, Momoko Okuda, Ichio Onami, Miho Ayabe, Akira Takeiri, Hideyuki Konishi, Yui Sugawara, Shoko Usami, Eriko Ito, Norihito Shibahara, Kazuhisa Ozeki, Yukiko Wada, Ayano Hirako, Noriyuki Takahashi, Zenjiro Sampei, Kenta Haraya, Naoaki Murao, Takashi Fujii, Takuya Torizawa, Hideaki Shimada, Tomoyuki Igawa   +27 more
doaj   +2 more sources

Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs

Frontiers in Immunology, 2022
The most commonly used markers to assess complement activation are split products that are produced through activation of all three pathways and are located downstream of C3. In contrast, C4d derives from the cleavage of C4 and indicates either classical
Erika Kajdácsi, György Sinkovits, Laszlo Cervenak   +2 more
exaly   +3 more sources

The Role of Exchange Energy in Modeling Core-Electron Binding Energies of Strongly Polar Bonds [PDF]

Molecules
Accurate determination of carbon core-electron binding energies (C1s CEBEs) is crucial for X-ray photoelectron spectroscopy (XPS) assignments and predictive computational modeling.
Feng Wang, Delano P. Chong
doaj   +2 more sources

Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches

Molecules, 2019
The complement system is associated with various diseases such as inflammation or auto-immune diseases. Complement-targeted drugs could provide novel therapeutic intervention against the above diseases.
István Hajdú, György Dormán, Katalin Szilagyi   +2 more
exaly   +3 more sources

C1s targeting antibodies inhibit the growth of cutaneous squamous carcinoma cells

Scientific Reports
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The incidence of cSCC is increasing globally and the prognosis of metastatic disease is poor.
Liisa Nissinen, Pilvi Riihilä, Kristina Viiklepp   +2 more
exaly   +2 more sources

Computational Investigation of Smooth Muscle Cell Plasticity in Atherosclerosis and Vascular Calcification: Insights from Differential Gene Expression Analysis of Microarray Data [PDF]

Bioengineering
The dedifferentiation of smooth muscle cells (SMCs) is the main cause of atherosclerosis and vascular calcification. This study integrated the gene expression data of multiple microarrays to identify relevant marker molecules.
Daniel Liu, Jimmy Kuo, Chorng-Horng Lin
doaj   +2 more sources

Quantitative fluorescence resonance energy transfer-based immunoassay for activated complement C1s

Frontiers in Immunology, 2023
ObjectivesC1s activation is associated with the pathogenesis of various diseases, indicating the potential value of C1s activation detection in clinic.
Jun Ye, Jun Ye, Jie Xu, Chuanmeng Zhang, Li Zhu, Sheng Xia   +5 more
doaj   +1 more source

HMGB1 cleavage by complement C1s and its potent anti-inflammatory product

Frontiers in Immunology, 2023
Complement C1s association with the pathogenesis of several diseases cannot be simply explained only by considering its main role in activating the classical complement pathway.
Marie Lorvellec, Anne Chouquet, Jonas Koch, Isabelle Bally, Luca Signor, Jeanne Vigne, Fabien Dalonneau, Nicole M. Thielens, Thierry Rabilloud, Bastien Dalzon, Véronique Rossi, Christine Gaboriaud   +11 more
doaj   +1 more source