Results 1 to 10 of about 231,543 (135)
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. [PDF]
PLoS Pathogens, 2016 Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system.
Brandon L Garcia +4 more
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C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions [PDF]
Frontiers in Immunology, 2017 Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases.
Jinhua Lu, Uday Kishore
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The axis of complement C1 and nucleolus in antinuclear autoimmunity
Frontiers in Immunology, 2023 Antinuclear autoantibodies (ANA) are heterogeneous self-reactive antibodies that target the chromatin network, the speckled, the nucleoli, and other nuclear regions.
Shan Wu +15 more
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Frontiers in Immunology, 2023 BackgroundDysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrullinated proteins are hallmarks of rheumatoid arthritis (RA).
Myriam Martin +14 more
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Heliyon, 2022 Acquired angioedema due to C1-inhibitor deficiency (C1–INH-AAE) is a rare disease that can be diagnosed via complement testing. It often accompanies lymphoproliferative underlying diseases.
Zsofia Polai +4 more
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Potential therapeutic benefit of C1-esterase inhibitor in neuromyelitis optica evaluated in vitro and in an experimental rat model. [PDF]
PLoS ONE, 2014 Neuromyelitis optica (NMO) is an autoimmune demyelinating disease of the central nervous system in which binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) to astrocytes causes complement-dependent cytotoxicity (CDC) and inflammation resulting ...
Lukmanee Tradtrantip +3 more
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Models of the complement C1 complex [PDF]
Proceedings of the National Academy of Sciences, 2018 Almitairi et al. (1) present structural information on the interaction between the proteases C1r and C1s, both consisting of six domains, called CUB1-EGF-CUB2-CCP1-CCP2-SP. The authors also propose a model for the C1 complex where the C1r2s2 tetramer is bound to C1q. Using our published and deposited small-angle X-ray scattering (SAXS) data (2) for the
Simon A. Mortensen +6 more
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Structure of the C1 complex of complement [PDF]
Proceedings of the National Academy of Sciences, 2017 In PNAS, Mortensen et al. (1) propose a model of the C1 complex of complement derived from small-angle X-ray scattering (SAXS) and electron microscopy (EM) analyses that contradicts previously published models and suggests an intermolecular activation process. This proposal is largely derived from a conjectural structure of C1r2C1s2, the catalytic unit
Arlaud, Gérard J +3 more
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Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice. [PDF]
PLoS ONE, 2017 C1 esterase inhibitor (C1-INH) can inhibit multiple pathways (complement, contact-kinin, coagulation, and fibrinolysis) that are all implicated in the pathophysiology of asthma.
Ingrid Stroo +11 more
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Identification of defensin binding to C1 complement [PDF]
FEBS Letters, 1994 In human serum we found strong defensin binding to the complexes of activated C1 complement (C) and C1 inhibitor (C1i). Purified C1q, activated C1 tetramer ( 2 2) and C1i did not bind defensin. When ( 2 2) was dissociated by EDTA, only the activated C1s (Cs) bound defensin.
Panyutich, Alexander V. +4 more
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