Results 11 to 20 of about 277,579 (267)

Effect of complement C1-esterase inhibitor on brain edema and inflammation after mild traumatic brain injury in an animal model [PDF]

Clinical and Experimental Emergency Medicine, 2020
Objective Traumatic brain injury (TBI) is characterized by damage to the blood-brain barrier, inflammation, and edema formation. In this pilot study, we aimed to investigate the effects of a complement inhibitor, C1-esterase inhibitor (C1 INH), on brain ...
Eric Weiss, Teena Dhir, Abigail Collett, Michal Reola, Mark Kaplan, Corrado Minimo, Laurel Omert, Pak Leung   +7 more
doaj   +2 more sources

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis [PDF]

Neural Regeneration Research
Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus, leading to long-term cognitive impairment. However, the mechanism underlying this neurogenesis impairment remains unknown. In this study, we established a male
Jing Wang, Bing Zhang, Lanfang Li, Xiaomei Tang, Jinyu Zeng, Yige Song, Chao Xu, Kai Zhao, Guoqiang Liu, Youming Lu, Xinyan Li, Kai Shu   +11 more
doaj   +2 more sources

Inhibition of Immune Complex Complement Activation and Neutrophil Extracellular Trap Formation by Peptide Inhibitor of Complement C1 [PDF]

Frontiers in Immunology, 2018
Two major aspects of systemic lupus erythematosus (SLE) pathogenesis that have yet to be targeted therapeutically are immune complex-initiated complement activation and neutrophil extracellular trap (NET) formation by neutrophils.
Pamela S. Hair, Adrianne I. Enos, Neel K. Krishna, Neel K. Krishna, Kenji M. Cunnion, Kenji M. Cunnion, Kenji M. Cunnion, Kenji M. Cunnion   +7 more
doaj   +2 more sources

Peptide inhibitor of complement C1 (PIC1), a novel suppressor of classical pathway activation: mechanistic studies and clinical potential [PDF]

Frontiers in Immunology, 2014
The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses as well as an essential homeostatic role in the clearance of damaged self-antigens.
Julia A Sharp, Pamela H. Whitley, Kenji M. Cunnion, Kenji M. Cunnion, Neel Kumar Krishna, Neel Kumar Krishna   +5 more
doaj   +2 more sources

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats. [PDF]

PLoS ONE, 2015
The complement system has been increasingly recognized to play a pivotal role in a variety of inflammatory and autoimmune diseases. Consequently, therapeutic modulators of the classical, lectin and alternative pathways of the complement system are ...
Julia A Sharp, Pamela S Hair, Haree K Pallera, Parvathi S Kumar, Clifford T Mauriello, Julius O Nyalwidhe, Cody A Phelps, Dalnam Park, Nicole M Thielens, Stephen M Pascal, Waldon Chen, Diane M Duffy, Frank A Lattanzio, Kenji M Cunnion, Neel K Krishna   +14 more
doaj   +2 more sources

C1 esterase inhibitor-mediated immunosuppression in COVID-19: Friend or foe?

Clinical Immunology Communications, 2022
From asymptomatic to severe, SARS-CoV-2, causative agent of COVID-19, elicits varying disease severities. Moreover, understanding innate and adaptive immune responses to SARS-CoV-2 is imperative since variants such as Omicron negatively impact adaptive ...
Melissa A. Hausburg, Jason S. Williams, Kaysie L. Banton, Charles W. Mains, Michael Roshon, David Bar-Or   +5 more
doaj   +1 more source

Structure of the C1r–C1s interaction of the C1 complex of complement activation [PDF]

Proceedings of the National Academy of Sciences, 2018
SignificanceC1 is a large complex that triggers the destruction of invading pathogens via lysis or by stimulation of innate and adaptive immune processes. It is composed of C1q, a protein with a bouquet-like architecture, together with a tetramer assembled from two copies each of the serine proteases C1r and C1s, which activate when C1q binds to a ...
Jamal O. M. Almitairi, Umakhanth Venkatraman Girija, Christopher M. Furze, Xanthe Simpson-Gray, Farah Badakshi, Jamie E. Marshall, Wilhelm J. Schwaeble, Daniel A. Mitchell, Peter C. E. Moody, Russell Wallis   +9 more
openaire   +4 more sources

Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus

Viruses, 2023
Adenovirus has strong therapeutic potential as an oncolytic virus and gene therapy vector. However, injecting human species C serotype 5 adenovirus, HAdv-C5, into the bloodstream leads to numerous interactions with plasma proteins that affect viral ...
Nicole Wagner, Dmitry M. Shayakhmetov, Phoebe L. Stewart   +2 more
doaj   +1 more source

Combined anti-C1-INH and radiotherapy against glioblastoma

BMC Cancer, 2023
Background A more effective immune response against glioblastoma is needed in order to achieve better tumor control. Radiotherapy can induce anti-tumor mediated immune reactions, in addition to its dose response effects.
Emma Liljedahl, Elise Konradsson, Emma Gustafsson, Karolina Förnvik Jonsson, Jill K. Olofsson, Kurt Osther, Crister Ceberg, Henrietta Nittby Redebrandt   +7 more
doaj   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H., Mitchell, Daniel A., Schmid, Ralf, Schwaeble, Wilhelm J., Wallis, Russell   +4 more
core   +1 more source