Identification of defensin binding to C1 complement [PDF]
FEBS Letters, 1994 In human serum we found strong defensin binding to the complexes of activated C1 complement (C) and C1 inhibitor (C1i). Purified C1q, activated C1 tetramer ( 2 2) and C1i did not bind defensin. When ( 2 2) was dissociated by EDTA, only the activated C1s (Cs) bound defensin.
Panyutich, Alexander V. +4 more
openaire +4 more sources
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. [PDF]
PLoS Pathogens, 2016 Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system.
Brandon L Garcia +4 more
doaj +3 more sources
Heliyon, 2022 Acquired angioedema due to C1-inhibitor deficiency (C1–INH-AAE) is a rare disease that can be diagnosed via complement testing. It often accompanies lymphoproliferative underlying diseases.
Zsofia Polai +4 more
doaj +1 more source
Effects of weak anchoring on C1 and C2 chevron structures [PDF]
, 2005 We present a theoretical study of the effect of weak anchoring on the transition between C1 and C2 chevron structures in smectic C liquid crystals. We employ a continuum theory which allows for variable cone, azimuthal and layer tilt angles.
Mottram, Nigel +2 more
core +5 more sources
Potential therapeutic benefit of C1-esterase inhibitor in neuromyelitis optica evaluated in vitro and in an experimental rat model. [PDF]
PLoS ONE, 2014 Neuromyelitis optica (NMO) is an autoimmune demyelinating disease of the central nervous system in which binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) to astrocytes causes complement-dependent cytotoxicity (CDC) and inflammation resulting ...
Lukmanee Tradtrantip +3 more
doaj +1 more source
Structure of the C1 complex of complement [PDF]
Proceedings of the National Academy of Sciences, 2017 In PNAS, Mortensen et al. (1) propose a model of the C1 complex of complement derived from small-angle X-ray scattering (SAXS) and electron microscopy (EM) analyses that contradicts previously published models and suggests an intermolecular activation process. This proposal is largely derived from a conjectural structure of C1r2C1s2, the catalytic unit
Arlaud, Gérard J +3 more
openaire +4 more sources
Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice. [PDF]
PLoS ONE, 2017 C1 esterase inhibitor (C1-INH) can inhibit multiple pathways (complement, contact-kinin, coagulation, and fibrinolysis) that are all implicated in the pathophysiology of asthma.
Ingrid Stroo +11 more
doaj +1 more source
Structure of the C1r–C1s interaction of the C1 complex of complement activation [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance C1 is a large complex that triggers the destruction of invading pathogens via lysis or by stimulation of innate and adaptive immune processes. It is composed of C1q, a protein with a bouquet-like architecture, together with a tetramer assembled from two copies each of the serine proteases C1r and C1s, which activate when ...
Jamal O. M. Almitairi +9 more
openaire +5 more sources
C1 esterase inhibitor-mediated immunosuppression in COVID-19: Friend or foe?
Clinical Immunology Communications, 2022 From asymptomatic to severe, SARS-CoV-2, causative agent of COVID-19, elicits varying disease severities. Moreover, understanding innate and adaptive immune responses to SARS-CoV-2 is imperative since variants such as Omicron negatively impact adaptive ...
Melissa A. Hausburg +5 more
doaj +1 more source
Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus
Viruses, 2023 Adenovirus has strong therapeutic potential as an oncolytic virus and gene therapy vector. However, injecting human species C serotype 5 adenovirus, HAdv-C5, into the bloodstream leads to numerous interactions with plasma proteins that affect viral ...
Nicole Wagner +2 more
doaj +1 more source