Results 31 to 40 of about 277,579 (267)

C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage.

PLoS ONE, 2013
BackgroundIschemia/reperfusion injury of lower extremities and associated lung damage may result from thrombotic occlusion, embolism, trauma, or surgical intervention with prolonged ischemia and subsequent restoration of blood flow.
Claudia Duehrkop, Yara Banz, Rolf Spirig, Sylvia Miescher, Marc W Nolte, Martin Spycher, Richard A G Smith, Steven H Sacks, Robert Rieben   +8 more
doaj   +1 more source

Proteomic profiling of IgA nephropathy reveals distinct molecular prognostic subtypes

iScience, 2023
Summary: IgA nephropathy (IgAN) is a heterogeneous disease, which poses a series of challenges to accurate diagnosis and personalized therapy. Herein, we constructed a systematic quantitative proteome atlas from 59 IgAN and 19 normal control donors ...
Xizhao Chen, Mansheng Li, Songbiao Zhu, Yang Lu, Shuwei Duan, Xu Wang, Yong Wang, Pu Chen, Jie Wu, Di Wu, Zhe Feng, Guangyan Cai, Yunping Zhu, Haiteng Deng, Xiangmei Chen   +14 more
doaj   +1 more source

The carbohydrate-linked phosphorylcholine of the parasitic nematode product ES-62 modulates complement activation [PDF]

, 2016
Parasitic nematodes manufacture various carbohydratelinked phosphorylcholine (PCh)-containing molecules, including ES-62, a protein with an N-linked glycan terminally substituted with PCh.
Ahmed, Umul Kulthum, Al-Riyami, Lamyaa, Harnett, William, Iqbal, Asif J., Maller, N. Claire, Raynes, John G.   +5 more
core   +1 more source

C1 inhibitor in canine intravascular hemolysis (C1INCH): study protocol for a randomized controlled trial

BMC Veterinary Research, 2019
Background Immune-mediated hemolytic anemia (IMHA) is a common disease that affects all breeds of dogs and is associated with significant morbidity and mortality.
Robert Goggs, Erica Behling-Kelly
doaj   +1 more source

Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains

Nature Communications, 2023
IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and enhanced effector functions, including highly efficient pathogen neutralisation and complement activation.
Leoni Abendstein, Douwe J. Dijkstra, Rayman T. N. Tjokrodirijo, Peter A. van Veelen, Leendert A. Trouw, Paul J. Hensbergen, Thomas H. Sharp   +6 more
doaj   +1 more source

Diagnosing Pediatric Patients With Hereditary C1-Inhibitor Deficiency—Experience From the Hungarian Angioedema Center of Reference and Excellence

Frontiers in Allergy, 2022
BackgroundHereditary Angioedema with C1-inhibitor deficiency (C1-INH-HAE) is a rare disease characterized by recurrent subcutaneous and/or submucosal edematous (HAE) episodes, which may occur at any age.
Noémi Andrási, Noémi Andrási, Noémi Andrási, Zsuzsanna Balla, Zsuzsanna Balla, Beáta Visy, Beáta Visy, Ágnes Szilágyi, Dorottya Csuka, Lilian Varga, Henriette Farkas   +10 more
doaj   +1 more source

Coloring Sums of Extensions of Certain Graphs [PDF]

, 2016
Recall that the minimum number of colors that allow a proper coloring of graph $G$ is called the chromatic number of $G$ and denoted by $\chi(G).$ In this paper the concepts of $\chi$'-chromatic sum and $\chi^+$-chromatic sum are introduced. The extended
Bej, Saptarshi, Kok, Johan
core   +4 more sources

Regulation of Complement and Contact System Activation via C1 Inhibitor Potentiation and Factor XIIa Activity Modulation by Sulfated Glycans - Structure-Activity Relationships.

PLoS ONE, 2016
The serpin C1 inhibitor (C1-INH) is the only regulator of classical complement activation as well as the major regulator of the contact system. Its importance is demonstrated by hereditary angioedema (HAE), a severe disease with potentially life ...
Ann-Kathrin Schoenfeld, Eric Lahrsen, Susanne Alban   +2 more
doaj   +1 more source

C1-inactivator is upregulated in glioblastoma.

PLoS ONE, 2017
BackgroundGlioblastoma is the most common and aggressive type of primary brain tumor in adults. A key problem is the capacity of glioma cells to inactivate the body's immune response.
Karolina Förnvik, Aida Maddahi, Oscar Persson, Kurt Osther, Leif G Salford, Henrietta Nittby Redebrandt   +5 more
doaj   +1 more source

Rewriting Abstract Structures: Materialization Explained Categorically [PDF]

, 2019
The paper develops an abstract (over-approximating) semantics for double-pushout rewriting of graphs and graph-like objects. The focus is on the so-called materialization of left-hand sides from abstract graphs, a central concept in previous work.
Corradini, Andrea, Heindel, Tobias, König, Barbara, Nolte, Dennis, Rensink, Arend   +4 more
core   +2 more sources