Results 1 to 10 of about 5,894 (144)

Identification of novel gene and pathway targets for human epilepsy treatment

Biological Research
BACKGROUND: The aim of this study was to explore epilepsy-related mechanism so as to figure out the possible targets for epilepsy treatment. METHODS: The gene expression profile dataset GES32534 was downloaded from Gene Expression Omnibus database.
Ying Jin, Chunzhe Zhao, Lihui Chen, Xiangyu Liu, Shuxiao Pan, Dongsheng Ju, Jing Ma, Jinying Li, Bo Wei   +8 more
doaj   +1 more source

Complement C1s inhibition with sutimlimab results in durable response in cold agglutinin disease: CARDINAL study 1-year interim follow-up results. [PDF]

Haematologica, 2022
Roth A, Barcellini W, D'Sa S, Miyakawa Y, Broome CM, Michel M, Kuter DJ, Jilma B, Tvedt THA, Weitz IC, Patel P, Jiang X, Reuter C, Su J, Shafer F, Lee M, Berentsen S.   +16 more
europepmc   +1 more source

Plasma Proteomic Signatures in Alkaptonuria

Biology
Alkaptonuria (AKU) is a rare metabolic disorder caused by homogentisic acid accumulation and characterised by ochronosis, oxidative stress, chronic inflammation, and progressive connective tissue damage.
Rebecca Finetti, Anna Visibelli, Bianca Roncaglia, Alfonso Trezza, Luana Peruzzi, Barbara Marzocchi, Ottavia Spiga, Mattia Cicogni, Laura Salvini, Laura Tinti, Vittoria Cicaloni, Sara Cheleschi, Marco Rossi, Cristina Tinti, Annalisa Santucci   +14 more
doaj   +1 more source

sMR and PTX3 levels associate with COVID-19 outcome and survival but not with Long COVID

iScience
Summary: Biomarkers for monitoring COVID-19 disease course are lacking. Study aim was to identify biomarkers associated with disease severity, survival, long-term outcome, and Long COVID.
Lisa Hurler, Federica Mescia, Laura Bergamaschi, Erika Kajdácsi, György Sinkovits, László Cervenak, Zoltán Prohászka, Paul A. Lyons, Erik J.M. Toonen   +8 more
doaj   +1 more source

Point-of-care assessment of complement activation in the ICU: a feasibility study of rapid terminal complement complex detection in critical illness

Frontiers in Immunology
BackgroundComplement activation is increasingly recognized as a key driver in various critical diseases and a potential therapeutic target. However, conventional enzyme-linked immunosorbent assays (ELISAs) for complement protein detection are laboratory ...
Tam Cung, Tam Cung, Tam Cung, Søren Erik Pischke, Søren Erik Pischke, Søren Erik Pischke, Camilla Schjalm, Bettina Mülleder, Loek Willems, Max Sonnleitner, Erik J.M. Toonen, Tom Eirik Mollnes, Tom Eirik Mollnes, Andreas Barratt-Due, Andreas Barratt-Due, Andreas Barratt-Due   +15 more
doaj   +1 more source

Inhibition of complement C1s in patients with cold agglutinin disease: lessons learned from a named patient program. [PDF]

Blood Adv, 2020
Gelbenegger G, Schoergenhofer C, Derhaschnig U, Buchtele N, Sillaber C, Fillitz M, Schenk TM, D'Sa S, Cartwright R, Gilbert JC, Jilma B, Jaeger U.   +11 more
europepmc   +1 more source

Production and characterization of gigastasin, a leech-derived inhibitor of complement and coagulation pathways

Scientific Reports
The complement and coagulation systems protect against injury and infection, but ill-controlled activation may cause clinical complications. Despite their efficacy in defined indications, approved complement and coagulation inhibitors remain poorly ...
Aleksandra Blagojevic, Peter Rüthemann, Kevin Widmer, Marco Mannes, Dilara Caglar, Mateja Tiric, Mathew Ebin Sovichan, Richard B. Pouw, Said Rabbani, Markus Huber-Lang, Daniel Ricklin   +10 more
doaj   +1 more source

Complement activation in tumor microenvironment after neoadjuvant therapy and its impact on pancreatic cancer outcomes

npj Precision Oncology
Neoadjuvant therapy (NAT) is increasingly being used for pancreatic ductal adenocarcinoma (PDAC). This study investigates how NAT differentially impacts PDAC’s carcinoma cells and the tumor microenvironment (TME).
Xiaofei Zhang, Ruoxin Lan, Yongjun Liu, Venu G. Pillarisetty, Danting Li, Chaohui L. Zhao, Suparna A. Sarkar, Weiguo Liu, Iman Hanna, Mala Gupta, Cristina Hajdu, Jonathan Melamed, Michael Shusterman, Jessica Widmer, John Allendorf, Yao-Zhong Liu   +15 more
doaj   +1 more source