Results 21 to 30 of about 5,894 (144)

The axis of complement C1 and nucleolus in antinuclear autoimmunity

Frontiers in Immunology, 2023
Antinuclear autoantibodies (ANA) are heterogeneous self-reactive antibodies that target the chromatin network, the speckled, the nucleoli, and other nuclear regions.
Shan Wu, Shan Wu, Junjie Chen, Junjie Chen, Boon Heng Dennis Teo, Boon Heng Dennis Teo, Seng Yin Kelly Wee, Seng Yin Kelly Wee, Ming Hui Millie Wong, Ming Hui Millie Wong, Jianzhou Cui, Jinmiao Chen, Jinmiao Chen, Khai Pang Leong, Jinhua Lu, Jinhua Lu   +15 more
doaj   +3 more sources

The complement system contributes to the immunosuppressive microenvironment of uveal melanoma [PDF]

Journal of Translational Medicine
Background Uveal melanoma (UM) is a rare disease, but the most common intraocular malignancy in adults, with incidence rates in Europe ranging from 1.3 to 8.6 cases per million annually.
Iryna Zherka, Helen Kalirai, Dominika Majorova, Sarah E. Coupland, Monica M. Olcina   +4 more
doaj   +2 more sources

The Role of the Lys628 (192) Residue of the Complement Protease, C1s, in Interacting with Peptide and Protein Substrates

Frontiers in Immunology, 2014
The C1s protease of the classical complement pathway propagates the initial activation of this pathway of the system by cleaving and thereby activating the C4 and C2 complement components.
Lakshmi C Wijeyewickrema
exaly   +3 more sources

Models of the complement C1 complex [PDF]

Proceedings of the National Academy of Sciences, 2018
Almitairi et al. (1) present structural information on the interaction between the proteases C1r and C1s, both consisting of six domains, called CUB1-EGF-CUB2-CCP1-CCP2-SP. The authors also propose a model for the C1 complex where the C1r2s2 tetramer is bound to C1q. Using our published and deposited small-angle X-ray scattering (SAXS) data (2) for the
Simon A. Mortensen, Bjørn Sander, Rasmus K. Jensen, Jan S. Pedersen, Monika M. Golas, Steffen Thiel, Gregers R. Andersen   +6 more
openaire   +2 more sources

Structure of the C1 complex of complement [PDF]

Proceedings of the National Academy of Sciences, 2017
In PNAS, Mortensen et al. (1) propose a model of the C1 complex of complement derived from small-angle X-ray scattering (SAXS) and electron microscopy (EM) analyses that contradicts previously published models and suggests an intermolecular activation process. This proposal is largely derived from a conjectural structure of C1r2C1s2, the catalytic unit
Arlaud, Gérard J, Gaboriaud, Christine, Ling, Wai-Li, Thielens, Nicole   +3 more
openaire   +4 more sources

Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels

Journal of Neuroinflammation, 2023
Background Alzheimer’s disease (AD) has been associated with immune dysregulation in biomarker and genome-wide association studies (GWAS). GWAS hits include the genes encoding complement regulators clusterin (CLU) and complement receptor 1 (CR1 ...
Aurora Veteleanu, Joshua Stevenson-Hoare, Samuel Keat, Nikoleta Daskoulidou, Henrik Zetterberg, Amanda Heslegrave, Valentina Escott-Price, Julie Williams, Rebecca Sims, Wioleta M. Zelek, Sarah M. Carpanini, Bryan Paul Morgan   +11 more
doaj   +1 more source

Degradation of collagen I by activated C1s in periodontal Ehlers-Danlos Syndrome

Frontiers in Immunology, 2023
Periodontal Ehlers-Danlos syndrome (pEDS) is an autosomal dominant disorder characterized by early-onset periodontitis leading to premature loss of teeth, lack of attached gingiva and thin and fragile gums leading to gingival recession. Connective tissue
Albert Amberger, Johanna Pertoll, Pia Traunfellner, Ines Kapferer-Seebacher, Heribert Stoiber, Lars Klimaschewski, Nicole Thielens, Christine Gaboriaud, Johannes Zschocke   +8 more
doaj   +1 more source

Structure of the C1r–C1s interaction of the C1 complex of complement activation [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance C1 is a large complex that triggers the destruction of invading pathogens via lysis or by stimulation of innate and adaptive immune processes. It is composed of C1q, a protein with a bouquet-like architecture, together with a tetramer assembled from two copies each of the serine proteases C1r and C1s, which activate when ...
Jamal O. M. Almitairi, Umakhanth Venkatraman Girija, Christopher M. Furze, Xanthe Simpson-Gray, Farah Badakshi, Jamie E. Marshall, Wilhelm J. Schwaeble, Daniel A. Mitchell, Peter C. E. Moody, Russell Wallis   +9 more
openaire   +5 more sources

Identification of defensin binding to C1 complement [PDF]

FEBS Letters, 1994
In human serum we found strong defensin binding to the complexes of activated C1 complement (C) and C1 inhibitor (C1i). Purified C1q, activated C1 tetramer ( 2 2) and C1i did not bind defensin. When ( 2 2) was dissociated by EDTA, only the activated C1s (Cs) bound defensin.
Panyutich, Alexander V., Szold, Oded, Poon, Pak H., Tseng, Yiou, Ganz, Tomas   +4 more
openaire   +2 more sources

Identification of Diagnostic Biomarkers and Their Correlation with Immune Infiltration in Age-Related Macular Degeneration

Diagnostics, 2021
Age-related macular degeneration (AMD) is a progressive neurodegenerative disease of the central retina, with no suitable biomarkers for early diagnosis and treatment.
Yuyang Zeng, Xiujuan Yin, Changzheng Chen, Yiqiao Xing   +3 more
doaj   +1 more source