Results 21 to 30 of about 12,621 (239)

Two Different Missense C1S Mutations, Associated to Periodontal Ehlers-Danlos Syndrome, Lead to Identical Molecular Outcomes

Frontiers in Immunology, 2019
Ehlers-Danlos syndromes (EDS) are clinically and genetically heterogeneous disorders characterized by soft connective tissue alteration like joint hypermobility and skin hyper-extensibility. We previously identified heterozygous missense mutations in the
Isabelle Bally, Fabien Dalonneau, Anne Chouquet, Rebekka Gröbner, Albert Amberger, Ines Kapferer-Seebacher, Heribert Stoiber, Johannes Zschocke, Nicole M. Thielens, Véronique Rossi, Christine Gaboriaud   +10 more
doaj   +1 more source

TMT-Based Proteomics Reveal the Mechanism of Action of Amygdalin against Rheumatoid Arthritis in a Rat Model through Regulation of Complement and Coagulation Cascades

Molecules, 2023
The limitations of current medications for treating rheumatoid arthritis (RA) emphasize the urgent need for the development of new drugs. This study aimed to investigate the potential anti-RA mechanism of amygdalin using tandem mass tag (TMT)-based ...
Lan Zhou, Jun-Hong Chai, Yi Zhang, Xiao-Jie Jing, Xiang-Wen Kong, Jun Liang, Yong-Gang Xia   +6 more
doaj   +1 more source

Evaluation of the immunomodulatory activities of the probiotic strain lactobacillus fermentum UCO-979C [PDF]

, 2019
Lactobacillus fermentum UCO-979C, a strain isolated from a human stomach, was previously characterized by its potential probiotic properties. The UCO-979C strain displayed the ability to beneficially regulate the innate immune response triggered by ...
Alvarez, Gladis Susana, Clua, Maria Patricia, Garcia Cancino, Apolinaria, Garcia Castillo, Valeria, Indo, Yuhki, Islam, M. Aminul, Kitazawa, Haruki, Komatsu, Ryoya, Salva, Maria Susana, Takagi, Michihiro, Takahashi, Hideki, Villena, Julio Cesar   +11 more
core   +1 more source

Complement Components Showed a Time-Dependent Local Expression Pattern in Constant and Acute White Light-Induced Photoreceptor Damage

Frontiers in Molecular Neuroscience, 2017
Background: Photoreceptor cell death due to extensive light exposure and induced oxidative-stress are associated with retinal degeneration. A correlated dysregulation of the complement system amplifies the damaging effects, but the local and time ...
Nicole Schäfer, Antje Grosche, Sabrina I. Schmitt, Barbara M. Braunger, Diana Pauly   +4 more
doaj   +1 more source

The axis of complement C1 and nucleolus in antinuclear autoimmunity

Frontiers in Immunology, 2023
Antinuclear autoantibodies (ANA) are heterogeneous self-reactive antibodies that target the chromatin network, the speckled, the nucleoli, and other nuclear regions.
Shan Wu, Shan Wu, Junjie Chen, Junjie Chen, Boon Heng Dennis Teo, Boon Heng Dennis Teo, Seng Yin Kelly Wee, Seng Yin Kelly Wee, Ming Hui Millie Wong, Ming Hui Millie Wong, Jianzhou Cui, Jinmiao Chen, Jinmiao Chen, Khai Pang Leong, Jinhua Lu, Jinhua Lu   +15 more
doaj   +1 more source

Non-unitarisable representations and maximal symmetry [PDF]

, 2014
We investigate questions of maximal symmetry in Banach spaces and the structure of certain bounded non-unitarisable groups on Hilbert space. In particular, we provide structural information about bounded groups with an essentially unique invariant ...
Ferenczi, Valentin, Rosendal, Christian
core   +1 more source

Complement evasion factor (CEF), a novel immune evasion factor of Streptococcus pyogenes

Virulence, 2022
Streptococcus pyogenes, a leading human pathogen, is responsible for a wide range of diseases, including skin and soft tissue infections and severe invasive diseases. S.
Haniyeh Aghababa, Yi Tian Ting, Devaki Pilapitiya, Jacelyn M.S. Loh, Paul G. Young, Thomas Proft   +5 more
doaj   +1 more source

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

First‐in‐human study with SAR445088: A novel selective classical complement pathway inhibitor

Clinical and Translational Science, 2023
SAR445088 is an anti‐C1s humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system and has the potential to provide clinical benefit in the treatment of complement‐mediated diseases.
Timothy Chow, Pirouz Shamszad, Christopher Vinnard, Esther Yoon, Julia Belinski, Irene Karpenko, Laurent Perrin, Kristen Auwarter, Michael Storek, Howard Surks, Nancy Wong, Yehuda Z. Cohen   +11 more
doaj   +1 more source

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. [PDF]

, 2015
Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells.
Fishbein, MC, Gjertson, D, Mulder, A, Panicker, S, Parry, GC, Reed, EF, Thomas, KA, Valenzuela, NM   +7 more
core   +1 more source