Results 41 to 50 of about 12,621 (239)

Novel scabies mite serpins inhibit the three pathways of the human complement system. [PDF]

PLoS ONE, 2012
Scabies is a parasitic infestation of the skin by the mite Sarcoptes scabiei that causes significant morbidity worldwide, in particular within socially disadvantaged populations. In order to identify mechanisms that enable the scabies mite to evade human
Angela Mika, Simone L Reynolds, Frida C Mohlin, Charlene Willis, Pearl M Swe, Darren A Pickering, Vanja Halilovic, Lakshmi C Wijeyewickrema, Robert N Pike, Anna M Blom, David J Kemp, Katja Fischer   +11 more
doaj   +1 more source

Exploring the Functional Basis of Epigenetic Aging in Relation to Body Fat Phenotypes in the Norfolk Island Cohort

Current Issues in Molecular Biology, 2023
DNA methylation is an epigenetic factor that is modifiable and can change over a lifespan. While many studies have identified methylation sites (CpGs) related to aging, the relationship of these to gene function and age-related disease phenotypes remains
Thao Van Cao, Heidi G. Sutherland, Miles C. Benton, Larisa M. Haupt, Rodney A. Lea, Lyn R. Griffiths   +5 more
doaj   +1 more source

The linear quadratic regulator problem for a class of controlled systems modeled by singularly perturbed Ito differential equations [PDF]

, 2012
This paper discusses an infinite-horizon linear quadratic (LQ) optimal control problem involving state- and control-dependent noise in singularly perturbed stochastic systems.
Assawinchaichote W., Dragan V., Dragan V., Dragan V., Glizer V. Y., Hiroaki Mukaidani, Peng Shi, Shi P., Vasile Dragan   +8 more
core   +2 more sources

Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina

Cell Reports, 2019
Summary: Complement dysregulation is a feature of many retinal diseases, yet mechanistic understanding at the cellular level is limited. Given this knowledge gap about which retinal cells express complement, we performed single-cell RNA sequencing on ∼92,
Diana Pauly, Divyansh Agarwal, Nicholas Dana, Nicole Schäfer, Josef Biber, Kirsten A. Wunderlich, Yassin Jabri, Tobias Straub, Nancy R. Zhang, Avneesh K. Gautam, Bernhard H.F. Weber, Stefanie M. Hauck, Mijin Kim, Christine A. Curcio, Dwight Stambolian, Mingyao Li, Antje Grosche   +16 more
doaj   +1 more source

Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex [PDF]

, 2016
Citation: Garcia, B. L., Zhi, H., Wager, B., Hook, M., & Skare, J. T. (2016). Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. Plos Pathogens, 12(1), 28.
A Alitalo, A Hubner, A Roos, A Sadziene, A Sadziene, AE Davis 3rd, AG Barbour, AP van Dam, B Major, Beau Wager, BK Boardman, Brandon L. Garcia, BV Geisbrecht, C Gaboriaud, CA Brissette, CJ Hastey, CS Brooks, D Ricklin, D Ricklin, D. Scott Samuels, DS Samuels, E Fikrig, EA Rogers, EA Rogers, EH Weening, ER Lewis, G Harris, G Stanek, Girija U Venkatraman, H Zhi, Hui Zhi, I Bally, J Hellwage, J Pietikainen, J Schwab, J Seshu, JA Caine, JA Hyde, JD Lambris, JD Radolf, JH Kim, Jon T. Skare, JR Fischer, JV McDowell, JV McDowell, K Kurtenbach, KM Hovis, LK Bockenstedt, LY Lee, M Hammel, M He, M Jozsi, M Labandeira-Rey, M Pausa, Magnus Höök, MB Lawrenz, MC Carroll, MC Carroll, ME Woodman, MJ Caimano, MN Burtnick, MR Kenedy, MR Kenedy, MU Norman, NA Meenan, NM Thielens, P Kraiczy, P Kraiczy, PF Zipfel, R Wallis, RA Elsner, RA Gaultney, RJ Bingham, RJ Ziccardi, RJ Ziccardi, S Grosskinsky, S Prabhakaran, S Raibaud, S Thiel, SK Kochi, SW de Taeye, T Bykowski, T Hallstrom, T Hallstrom, T Meri, TF Busby, TJ Moriarty, U Schwarz-Linek, UK Laemmli, V Cook, WK Ip, WS Probert, WS Probert, WS Probert, X Li, X Yang, XF Yang, Y Wu, YP Ko, YP Ko, YP Lin, ZR Marjenberg   +101 more
core   +4 more sources

Plasma complement biomarkers distinguish multiple sclerosis and neuromyelitis optica spectrum disorder [PDF]

, 2016
Background: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are autoimmune demyelinating diseases distinguished clinically by selective involvement in NMOSD of optic nerves and spinal cord. Early clinical manifestations are
Evans, David R. S., Hakobyan, Svetlana, Harding, Katharine, Loveless, Samantha, Luppe, Sebastian, Morgan, Bryan Paul, Robertson, Neil P.   +6 more
core   +1 more source

Multifocal periapical cemental dysplasia in periodontal Ehlers–Danlos syndrome combined with leukoencephalopathy in the mutation of c.890G > a, G297D [pEDS]

Clinical Case Reports, 2022
Periodontal Ehlers‐Danlos syndrome (pEDS) is a rare disorder caused by heterozygous mutations in complement 1 subunit genes C1R and C1S. To date, 148 cases have been described in the literature.We describe a case of a suspected de novo‐mutation of pEDS ...
Manfred Nilius, Minou Helene Nilius, Charlotte Müller, Guenter Lauer, Koch Berit, Kohlhaas Marcus   +5 more
doaj   +1 more source

The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin. [PDF]

, 2013
International audienceMannan-binding lectin (MBL), ficolins and collectin-11 are known to associate with three homologous modular proteases, the MBL-Associated Serine Proteases (MASPs). The crystal structures of the catalytic domains of MASP-1 and MASP-2
A Sirmaci, AJ McCoy, AT Brunger, BC Lechtenberg, C Gaboriaud, C Gaboriaud, C Rooryck, Christine Gaboriaud, CL Cortesio, Claudio M. Soares, CM Stover, CT Eggers, D Heja, D Heja, D Iwaki, D Loew, E Di Cera, F Teillet, Florence Teillet, GJ Arlaud, GJ Arlaud, GN Murshudov, Gérard J. Arlaud, H Keshi, H Sekine, I Schechter, J Beattie, J Dobo, JA Huntington, JJ Perona, JJ Perona, JS Presanis, L Jin, Laurence Serre, Lydie Martin, M Budayova-Spano, M Budayova-Spano, M Lacroix, M Megyeri, M Megyeri, M Moller-Kristensen, M Takahashi, ME McGrath, MO Skjoedt, Monique Lacroix, MR Dahl, N Pozzi, Nicole M. Thielens, NM Thielens, P Emsley, P Roversi, R Sorensen, Rajesh Kumar Gupta, RM Dommett, RT Kidmose, S Hansen, S Zundel, SA Gillmor, SA Tsiftsoglou, SE Degn, SE Degn, SM Waugh, SQ Yang, SX Wang, SX Wang, TA Jones, V Harmat, V Rossi, V Rossi, Véronique Rossi, W Kabsch, W Niu, Y Endo   +72 more
core   +5 more sources

Canonical General Relativity on a Null Surface with Coordinate and Gauge Fixing [PDF]

, 1995
We use the canonical formalism developed together with David Robinson to st= udy the Einstein equations on a null surface. Coordinate and gauge conditions = are introduced to fix the triad and the coordinates on the null surface.
Ashtekar A, Ashtekar A (with invited contributions), Bondi H, C Soteriou, Chrusciel P T, Dirac P A M, Dray T, Glass E N, Goldberg J N, Goldberg J N, J N Goldberg, Newman E T, Newman E T, Newman E T, Novak S, Novak S, Penrose R, Sachs R, Sachs R, Samuel J, Torre C, Winicour J   +21 more
core   +2 more sources

Sprayable Polymer Blends With Short‐Chain Surface Segregation for Preventing Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
Adhesions’ high occurrence rates and high morbidity render them a critical challenge to be addressed. Current prevention methods, such as physical barriers, have many limitations, resulting in inconsistent safety and efficacy. This study demonstrates the potential for sprayable polymeric materials as an adhesion barrier.
Robert J. Morris III, Tejaswi Nori, Alex I. Halpern, Hannah LaPadula, Arthur V. Cresce, Sarah L. Wright, Anthony D. Sandler, Peter Kofinas   +7 more
wiley   +1 more source