Results 41 to 50 of about 5,894 (144)

Exploring the Functional Basis of Epigenetic Aging in Relation to Body Fat Phenotypes in the Norfolk Island Cohort

Current Issues in Molecular Biology, 2023
DNA methylation is an epigenetic factor that is modifiable and can change over a lifespan. While many studies have identified methylation sites (CpGs) related to aging, the relationship of these to gene function and age-related disease phenotypes remains
Thao Van Cao, Heidi G. Sutherland, Miles C. Benton, Larisa M. Haupt, Rodney A. Lea, Lyn R. Griffiths   +5 more
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Multifocal periapical cemental dysplasia in periodontal Ehlers–Danlos syndrome combined with leukoencephalopathy in the mutation of c.890G > a, G297D [pEDS]

Clinical Case Reports, 2022
Periodontal Ehlers‐Danlos syndrome (pEDS) is a rare disorder caused by heterozygous mutations in complement 1 subunit genes C1R and C1S. To date, 148 cases have been described in the literature.We describe a case of a suspected de novo‐mutation of pEDS ...
Manfred Nilius, Minou Helene Nilius, Charlotte Müller, Guenter Lauer, Koch Berit, Kohlhaas Marcus   +5 more
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Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases

Frontiers in Immunology, 2016
The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune complex-mediated ...
Katherine eLintner, Yee Ling eWu, Yan eYang, Charles eSpencer, Georges eHauptmann, Lee eHebert, John eAtkinson, Chack-Yung eYu   +7 more
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Construction of a competitive endogenous RNA network and analysis of potential regulatory axis targets in glioblastoma

Cancer Cell International, 2021
Background Glioblastoma is the most common primary malignant brain tumor. Because of the limited understanding of its pathogenesis, the prognosis of glioblastoma remains poor. This study was conducted to explore potential competing endogenous RNA (ceRNA)
Kai Yu, Huan Yang, Qiao-li Lv, Li-chong Wang, Zi-long Tan, Zhe Zhang, Yu-long Ji, Qian-xia Lin, Jun-jun Chen, Wei He, Zhen Chen, Xiao-li Shen   +11 more
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Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels

Frontiers in Immunology, 2023
BackgroundHaemostasis is a crucial process by which the body stops bleeding. It is achieved by the formation of a platelet plug, which is strengthened by formation of a fibrin mesh mediated by the coagulation cascade. In proinflammatory and prothrombotic
Murielle Golomingi, Jessie Kohler, Christina Lamers, Richard B. Pouw, Daniel Ricklin, József Dobó, Péter Gál, Gábor Pál, Bence Kiss, Arthur Dopler, Christoph Q. Schmidt, Elaissa Trybus Hardy, Elaissa Trybus Hardy, Elaissa Trybus Hardy, Wilbur Lam, Wilbur Lam, Wilbur Lam, Verena Schroeder   +17 more
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Fluid-phase interaction of C1 inhibitor (C1 Inh) and the subcomponents C1r and C1s of the first component of complement, C1 [PDF]

Biochemical Journal, 1982
Interactions between proenzymic or activated complement subcomponents of C1 and C1 Inh (C1 inhibitor) were analysed by sucrose-density-gradient ultracentrifugation and sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. The interaction of C1 Inh with dimeric C1r in the presence of EDTA resulted into two bimolecular complexes accounting for a ...
S, Chesne, C L, Villiers, G J, Arlaud, M B, Lacroix, M G, Colomb   +4 more
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Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface.

PLoS Pathogens, 2017
Whooping cough, or pertussis, is a contagious disease of the respiratory tract that is re-emerging worldwide despite high vaccination coverage. The causative agent of this disease is the Gram-negative Bordetella pertussis. Knowledge on complement evasion
Elise S Hovingh, Bryan van den Broek, Betsy Kuipers, Elena Pinelli, Suzan H M Rooijakkers, Ilse Jongerius   +5 more
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Protein-centric omics analysis reveals circulating complements linked to non-viral liver diseases as potential therapeutic targets [PDF]

Clinical and Molecular Hepatology
Background/Aims To evaluate the causal correlation between complement components and non-viral liver diseases and their potential use as druggable targets.
Yingzhou Shi, Hang Dong, Shiwei Sun, Xiaoqin Wu, Jiansong Fang, Jianbo Zhao, Junming Han, Zongyue Li, Huixiao Wu, Luna Liu, Wanhong Wu, Yang Tian, Guandou Yuan, Xiude Fan, Chao Xu   +14 more
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Peptide inhibitor of complement C1 (PIC1), a novel suppressor of classical pathway activation: mechanistic studies and clinical potential

Frontiers in Immunology, 2014
The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses as well as an essential homeostatic role in the clearance of damaged self-antigens.
Julia A Sharp, Pamela H. Whitley, Kenji M. Cunnion, Kenji M. Cunnion, Neel Kumar Krishna, Neel Kumar Krishna   +5 more
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Purificación del componente C1s del sistema complemento y obtención de un antisuero específico Purification of the C1s component of the complement system and obtention of a specific antiserum

Revista Cubana de Hematología, Inmunología y Hemoterapia, 1999
Se describe un método de purificación del componente C1s del sistema complemento a partir de una mezcla de sueros normales mediante cromatografías secuenciales en DEAE-celulosa, TEAE-celulosa y Sephacryl S-200.
Ada A Arce Hernández, Ed J Nieuwahuys, Andrew J Hannema   +2 more
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