Results 51 to 60 of about 5,894 (144)

Oversulfated chondroitin sulfate inhibits the complement classical pathway by potentiating C1 inhibitor. [PDF]

PLoS ONE, 2012
Oversulfated chondroitin sulfate (OSCS) has become the subject of multidisciplinary investigation as a non-traditional contaminant in the heparin therapeutic preparations that were linked to severe adverse events.
Zhao-Hua Zhou, Mohsen Rajabi, Trina Chen, Elena Karnaukhova, Steven Kozlowski   +4 more
doaj   +1 more source

Cell surface expression and function of the macromolecular C1 complex on the surface of human monocytes

Frontiers in Immunology, 2012
The synthesis of the subunits of the C1 complex (C1q, C1s, C1r), and its regulator C1 inhibitor (C1-Inh) by human monocytes has been previously established. However, surface expression of these molecules by monocytes has not been shown.
Kinga K Hosszu, Alisa eValentino, Yan eJi, Mara eMatkovic, Lina ePednekar, Nina eRehage, Nithin eTumma, Ellinor I.E. Peerschke, Berhane eGhebrehiwet   +8 more
doaj   +1 more source

Is there a link between genetic defects in the complement cascade and Porphyromonas gingivalis in Alzheimer’s disease?

Journal of Oral Microbiology, 2020
Defects, as determined by Genome-Wide Association Studies (GWAS), in the complement cascade of innate immunity have been suggested to play a key role in Alzheimer’s disease (AD). These defective genes encode sub-component 1s (C1s), complement receptor 1,
Ingar Olsen, Sim K Singhrao
doaj   +1 more source

Pan-cancer analysis identifies venous thromboembolism-related genes F3, PLAT, and C1S as potential prognostic biomarkers for glioblastoma and lower grade glioma

Molecular Biomedicine
Venous thromboembolism (VTE) is a prevalent complication among patients with cancer, contributing significantly to morbidity and mortality. However, the relationship between VTE-related genes (VRGs) and their potential impact on prognosis, immune ...
Jing Zhang, Qian Zhao, Yun Du, Wannan Wang, Cuiqing Liu   +4 more
doaj   +1 more source

C1s targeting antibodies inhibit the growth of cutaneous squamous carcinoma cells

Scientific Reports
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The incidence of cSCC is increasing globally and the prognosis of metastatic disease is poor.
Liisa Nissinen, Pilvi Riihilä, Kristina Viiklepp, Vaishnavi Rajagopal, Michael J. Storek, Veli-Matti Kähäri   +5 more
doaj   +1 more source

Regulation of Complement and Contact System Activation via C1 Inhibitor Potentiation and Factor XIIa Activity Modulation by Sulfated Glycans - Structure-Activity Relationships.

PLoS ONE, 2016
The serpin C1 inhibitor (C1-INH) is the only regulator of classical complement activation as well as the major regulator of the contact system. Its importance is demonstrated by hereditary angioedema (HAE), a severe disease with potentially life ...
Ann-Kathrin Schoenfeld, Eric Lahrsen, Susanne Alban   +2 more
doaj   +1 more source

Novel insights into the treatment of complement-mediated hemolytic anemias

Therapeutic Advances in Hematology, 2019
Complement-mediated hemolytic anemias can either be caused by deficiencies in regulatory complement components or by autoimmune pathogenesis that triggers inappropriate complement activation.
Sigbjørn Berentsen, Anita Hill, Quentin A. Hill, Tor Henrik Anderson Tvedt, Marc Michel   +4 more
doaj   +1 more source

MINI-REVIEW: SYSTEMIC LUPUS ERYTHEMATOSUS AND DEFICIENCIES OF EARLY COMPONENTS OF THE COMPLEMENT CLASSICAL PATHWAY

Frontiers in Immunology, 2016
The complement system plays an important role in the innate and acquired immune response against pathogens. It consists of more than 30 proteins found in soluble form or attached to cell membranes. Most complement proteins circulate in inactive forms and
Lourdes eIsaac, Ana Catarina Lunz Macedo
doaj   +1 more source

Proteomic results indicate inhibition of complement cascades is one of the mechanisms underlying the protective effects of Tongxinluo against myocardial infarction

Frontiers in Pharmacology
ObjectiveTongxinluo (TXL), a traditional Chinese medicine, has demonstrated cardioprotective effects in acute myocardial infarction (AMI), yet its impact on myocardial protein profiles remains largely unexplored.
Ziqin Zhou, Ziqin Zhou, Ce Zhang, Yao Jiang, Yuejin Yang, Guihao Chen, Qi Pan, Jimei Chen   +7 more
doaj   +1 more source

Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting Plasmodium falciparum cytoadherence. [PDF]

Proc Natl Acad Sci U S A, 2021
Azasi Y, Low LM, Just AN, Raghavan SSR, Wang CW, Valenzuela-Leon P, Rowe JA, Smith JD, Lavstsen T, Turner L, Calvo E, Miller LH.   +11 more
europepmc   +1 more source