C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation [PDF]
, 2015 Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation.
Agostinis, C +9 more
core +3 more sources
C1R Mutations Trigger Constitutive Complement 1 Activation in Periodontal Ehlers-Danlos Syndrome
Frontiers in Immunology, 2019 Heterozygous missense or in-frame insertion/deletion mutations in complement 1 subunits C1r and C1s cause periodontal Ehlers-Danlos Syndrome (pEDS), a specific EDS subtype characterized by early severe periodontal destruction and connective tissue ...
Rebekka Gröbner +13 more
doaj +1 more source
SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. [PDF]
, 2016 Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the ...
Abdeladhim, M. +18 more
core +1 more source
Identification of defensin binding to C1 complement [PDF]
FEBS Letters, 1994 In human serum we found strong defensin binding to the complexes of activated C1 complement (C) and C1 inhibitor (C1i). Purified C1q, activated C1 tetramer ( 2 2) and C1i did not bind defensin. When ( 2 2) was dissociated by EDTA, only the activated C1s (Cs) bound defensin.
Panyutich, Alexander V. +4 more
openaire +2 more sources
Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines. [PDF]
, 2018 Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries.
Bunn, David A +8 more
core +3 more sources
Structure of the C1 complex of complement [PDF]
Proceedings of the National Academy of Sciences, 2017 In PNAS, Mortensen et al. (1) propose a model of the C1 complex of complement derived from small-angle X-ray scattering (SAXS) and electron microscopy (EM) analyses that contradicts previously published models and suggests an intermolecular activation process. This proposal is largely derived from a conjectural structure of C1r2C1s2, the catalytic unit
Arlaud, Gérard J +3 more
openaire +4 more sources
Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]
, 2015 Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core +1 more source
Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches
Molecules, 2019 The complement system is associated with various diseases such as inflammation or auto-immune diseases. Complement-targeted drugs could provide novel therapeutic intervention against the above diseases.
Katalin Szilágyi +11 more
doaj +1 more source
PLoS ONE, 2020 Several candidate HIV subunit vaccines based on recombinant envelope (Env) glycoproteins have been advanced into human clinical trials. To facilitate biopharmaceutical production, it is necessary to produce these in CHO (Chinese Hamster Ovary) cells, the
Sophia W Li +7 more
doaj +1 more source
Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide [PDF]
, 2015 Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial ...
Abudureyimu, A +6 more
core +2 more sources