Complement C1s as a diagnostic marker and therapeutic target: Progress and propective [PDF]
Frontiers in Immunology, 2022 The molecules of the complement system connect the effectors of innate and adaptive immunity and play critical roles in maintaining homeostasis. Among them, the C1 complex, composed of C1q, C1r, and C1s (C1qr2s2), is the initiator of the classical ...
Yili Yang
exaly +4 more sources
Complement C1s deficiency in a male Caucasian patient with systemic lupus erythematosus: a case report [PDF]
Frontiers in Immunology, 2023 Deficiencies of the early complement components of the classical pathway (CP) are well-documented in association with systemic lupus erythematosus (SLE) or SLE-like syndromes and severe pyogenic infections.
Marten Trendelenburg +2 more
exaly +4 more sources
Quantitative fluorescence resonance energy transfer-based immunoassay for activated complement C1s [PDF]
Frontiers in Immunology, 2023 ObjectivesC1s activation is associated with the pathogenesis of various diseases, indicating the potential value of C1s activation detection in clinic.
Jun Ye +5 more
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The expression and biological role of complement C1s in esophageal squamous cell carcinoma [PDF]
Open Life SciencesThe present work focused on investigating the role of the altered expression of complement C1s in proliferation and apoptosis of esophageal squamous cell carcinoma (ESCC) cells and explore its biological functions in ESCC, so as to lay a theoretical ...
Ge Ruomu +5 more
exaly +3 more sources
HMGB1 cleavage by complement C1s and its potent anti-inflammatory product [PDF]
Frontiers in Immunology, 2023 Complement C1s association with the pathogenesis of several diseases cannot be simply explained only by considering its main role in activating the classical complement pathway.
Marie Lorvellec +11 more
doaj +2 more sources
C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions [PDF]
Frontiers in Immunology, 2017 Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases.
Jinhua Lu, Uday Kishore
doaj +5 more sources
C1s protects cutaneous squamous carcinoma cells from TRAIL-induced apoptosis [PDF]
OncogenesisCutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The prognosis of the metastatic cSCC is poor, and there are no established biomarkers to predict metastasis risk, nor specific targeted therapies for advanced or ...
Maria Salmela +7 more
doaj +2 more sources
Tumour cell-intrinsic complement C1r and C1s regulate cancer cell fitness and shape the immune microenvironment in triple-negative breast cancer [PDF]
Cellular and Molecular Life SciencesEmerging evidence positions tumour cell-intrinsic complement proteins as regulators of cancer cell behaviour and immune crosstalk, yet their role in triple-negative breast cancer (TNBC) remains undefined.
Andrea Minery +7 more
doaj +2 more sources
Frontiers in Immunology, 2022 The most commonly used markers to assess complement activation are split products that are produced through activation of all three pathways and are located downstream of C3. In contrast, C4d derives from the cleavage of C4 and indicates either classical
Jones Emma +2 more
exaly +3 more sources
Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement functionResearch in context [PDF]
EBioMedicineSummary: Background: Antibody drugs blocking the complement classical pathway (CP) often require frequent intravenous administration to overcome the high abundance or rapid turnover of complement proteins.
Adrian W.S. Ho +27 more
doaj +2 more sources