Frontiers in Immunology, 2022 The most commonly used markers to assess complement activation are split products that are produced through activation of all three pathways and are located downstream of C3. In contrast, C4d derives from the cleavage of C4 and indicates either classical
Lisa Hurler +156 more
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Structure of the C1r–C1s interaction of the C1 complex of complement activation [PDF]
Proceedings of the National Academy of Sciences, 2018 SignificanceC1 is a large complex that triggers the destruction of invading pathogens via lysis or by stimulation of innate and adaptive immune processes. It is composed of C1q, a protein with a bouquet-like architecture, together with a tetramer assembled from two copies each of the serine proteases C1r and C1s, which activate when C1q binds to a ...
Jamal O. M. Almitairi +9 more
openaire +6 more sources
Long-term efficacy and safety of continued complement C1s inhibition with sutimlimab in cold agglutinin disease: CADENZA study Part B. [PDF]
EClinicalMedicineRöth A +19 more
europepmc +2 more sources
Diagnostics, 2021 Age-related macular degeneration (AMD) is a progressive neurodegenerative disease of the central retina, with no suitable biomarkers for early diagnosis and treatment.
Yuyang Zeng +3 more
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Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H. +4 more
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Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica. [PDF]
, 2011 Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nasopharyngeal mucosal surface, but only N. meningitidis invades the bloodstream to cause potentially life-threatening meningitis and septicaemia.
Hibberd, Martin L +4 more
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Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937 [PDF]
, 2016 In order to evaluate probiotic strains applicable for the beneficial immunomodulation of the porcine gut (immunobiotics), we previously developed a porcine intestinal epitheliocyte cell line (PIE cells).
Albarracín, Leonardo Miguel +14 more
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Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]
, 2013 This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M +5 more
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Models of the complement C1 complex [PDF]
Proceedings of the National Academy of Sciences, 2018 Almitairi et al. (1) present structural information on the interaction between the proteases C1r and C1s, both consisting of six domains, called CUB1-EGF-CUB2-CCP1-CCP2-SP. The authors also propose a model for the C1 complex where the C1r2s2 tetramer is bound to C1q. Using our published and deposited small-angle X-ray scattering (SAXS) data (2) for the
Simon A. Mortensen +6 more
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Minimal generation of transitive permutation groups [PDF]
, 2018 It is proved in [21] that there is a constant $c$ such that each transitive permutation group of degree $d\ge 2$ can be generated by $\lfloor cd/\sqrt{\log{d}}\rfloor$ elements. In this paper, we explicitly estimate $c$
Tracey, Gareth M.
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