Results 21 to 30 of about 19,433 (259)
The axis of complement C1 and nucleolus in antinuclear autoimmunity
Frontiers in Immunology, 2023 Antinuclear autoantibodies (ANA) are heterogeneous self-reactive antibodies that target the chromatin network, the speckled, the nucleoli, and other nuclear regions.
Shan Wu +15 more
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Structure of the C1r–C1s interaction of the C1 complex of complement activation [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance C1 is a large complex that triggers the destruction of invading pathogens via lysis or by stimulation of innate and adaptive immune processes. It is composed of C1q, a protein with a bouquet-like architecture, together with a tetramer assembled from two copies each of the serine proteases C1r and C1s, which activate when ...
Jamal O. M. Almitairi +9 more
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C1-inhibitor/C1-inhibitor antibody complexes in acquired angioedema due to C1-inhibitor deficiency
Orphanet Journal of Rare Diseases, 2023 Abstract Background Autoantibodies against C1-inhibitor (C1-INH-Ab) have a diagnostic value in acquired angioedema due to C1-inhibitor deficiency (C1-INH-AAE), even though antibodies can circulate in complexes, which can be undetectable by proven methods.
Zsofia Polai +6 more
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C1R Mutations Trigger Constitutive Complement 1 Activation in Periodontal Ehlers-Danlos Syndrome
Frontiers in Immunology, 2019 Heterozygous missense or in-frame insertion/deletion mutations in complement 1 subunits C1r and C1s cause periodontal Ehlers-Danlos Syndrome (pEDS), a specific EDS subtype characterized by early severe periodontal destruction and connective tissue ...
Rebekka Gröbner +13 more
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The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin. [PDF]
PLoS ONE, 2013 Mannan-binding lectin (MBL), ficolins and collectin-11 are known to associate with three homologous modular proteases, the MBL-Associated Serine Proteases (MASPs). The crystal structures of the catalytic domains of MASP-1 and MASP-2 have been solved, but
Christine Gaboriaud +8 more
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Current Issues in Molecular Biology, 2023 DNA methylation is an epigenetic factor that is modifiable and can change over a lifespan. While many studies have identified methylation sites (CpGs) related to aging, the relationship of these to gene function and age-related disease phenotypes remains
Thao Van Cao +5 more
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C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions
Frontiers in Immunology, 2017 Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases.
Jinhua Lu, Uday Kishore
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Molecules, 2023 The limitations of current medications for treating rheumatoid arthritis (RA) emphasize the urgent need for the development of new drugs. This study aimed to investigate the potential anti-RA mechanism of amygdalin using tandem mass tag (TMT)-based ...
Lan Zhou +6 more
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Current Biology, 2002 What is it? Niemann-Pick C1 (NPC1) is a 1278 amino acid membrane protein residing in the endosomal–lysosomal system. Studies in humans and animal models substantiate NPC1 as a crucial player in intracellular cholesterol trafficking.Can we live without it?
Liscum, Laura, Wojtanik, Kari
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Engineering Proceedings, 2023 Here, I fill large 1.7 nm diameter single-walled carbon nanotubes (SWCNTs) with silver chloride (AgCl). I present photoemission insights into the filling of SWCNTs. C1s X-ray photoelectron spectroscopy (XPS) reveals the p-doping of SWCNTs.
Marianna V. Kharlamova
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