Results 121 to 130 of about 571,919 (313)

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Commentary: Comprehensive lipidome profiling of the kidney in early-stage diabetic nephropathy

Frontiers in Endocrinology, 2022
Katsumi Iizuka
doaj   +1 more source

07-1345-C18 [PDF]

Biomedical Engineering / Biomedizinische Technik, 2021
openaire   +1 more source

Addendum to `Fake Projective Planes'

, 2009
The addendum updates the results presented in the paper `Fake Projective Plane, Invent Math 168, 321-370 (2007)' and makes some additions and corrections. The fake projective planes are classified into twenty six classes.
A. Borel, D.I. Cartwright, G. Prasad, G. Prasad, Gopal Prasad, J. Rogawski, Sai-Kee Yeung, V. Kharlamov, W.P. Barth   +8 more
core   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

A highly selective TCR-mimic antibody reveals unexpected mechanisms of HBV peptide-MHC recognition and previously unknown target biology

mAbs
Curative therapies for chronic hepatitis B virus infection (CHB) are needed, and T-cell redirection is a promising approach, with peptide-MHC complexes (pMHC) being attractive targets. HBV core18–27 peptide (C18, 10-mer) presented by HLA-A*02:01 (C18-MHC)
Shahzada Khan, Jeremy Lum, Heather Stephenson, Pawan Bir Kohli, David Mortenson, Dhivya Ramakrishnan, Magdeleine Hung, Sheng Ding, Elbert Seto, Sabrina Lu, Randy Yen, Debi Jin, Brian Lee, Sheila Clancy, Nicole Schirle Oakdale, Nikolai Novikov, Don Kang, Ruidong Li, David Pan, Rutwij Dave, Eric Lansdon, Simon P Fletcher, Abhishek V. Garg, Nathan Thomsen, Scott Balsitis   +24 more
doaj   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Identification of plasma fatty acids as biomarkers for carcass traits and tissue-specific fatty acids profile in pigs

Frontiers in Animal Science
Carcass and pork traits have long been regarded as key phenotypes in pig breeding. The content and composition of fatty acids (FAs) play a crucial role in determining carcass and meat quality in pigs, as their regulation affects fat depositions.
Junhui Liu, Junhui Liu, Ioanna-Theoni Vourlaki, Cristina Sebastià, Cristina Sebastià, Ferran Llobet-Cabau, Ferran Llobet-Cabau, Armand Sánchez, Armand Sánchez, Anna Castelló, Anna Castelló, Yuliaxis Ramayo-Caldas, Maria Ballester, Josep M. Folch, Josep M. Folch   +14 more
doaj   +1 more source

Comparison of conjugated linoleic acid (CLA) content in milk of ewes and goats with the same dietary regimen [PDF]

, 2003
Milk fat is an important source of potential anticarcinogens named conjugated linoleic acid (CLA). The c9, t11-CLA is the major isomer and it is produced by ruminal hydrogenation of linoleic acid that leads first to vaccenic (11t-18:1) and finally to ...
Battacone, Gianni, Macciotta, Nicolò Pietro Paolo, Mele, Marcello, Nudda, Anna, Usai, Mario Graziano   +4 more
core  

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source