Results 201 to 210 of about 571,919 (313)

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

Development of a Quantitative Serial LC-MS/MS Method for Gut Microbiota Metabolomics. [PDF]

ACS Omega
Yoshida T, Shintani T, Sasaki D, Vavricka CJ, Matsuki Y, Kondo A, Hasunuma T.   +6 more
europepmc   +1 more source

Sinfonie (KomZ C18)

, 2021
openaire   +1 more source

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual‐Affinity Platform for High‐Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides

Advanced Science, EarlyView.
AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li, Wuming Fan, Xuyang Yue, Dongdong Wang, Xiangyu Tang, Zhuo Zhang, Yonggui Wang, Yanjun Xie, Mingliang Ye, Hongqiang Qin   +9 more
wiley   +1 more source

Hydrogen bonds or not? Synthesis and structure of 2,3-di-cyanona-phthalene-1,4-diyl bis-(4-methylbenzene-1-sulfonate). [PDF]

Acta Crystallogr E Crystallogr Commun
Akdemir N, Tahir MN, Ashfaq M.
europepmc   +1 more source

Erasable FAP Targeted Spray‐On Probe for Fluorescence‐Guided Surgery

Advanced Science, EarlyView.
We present the first erasable spray‐on probe for fluorescence‐guided surgery. Following topical delivery, FAP‐FLASH550 targets fibroblast activation protein–expressing stromal cells, delineating tumor margins with high tumor‐to‐background ratios. A 365 nm UV light pulse rapidly erases fluorescent signals through triazene photodegradation and subsequent
Zachary Rabinowitz, Riley J. Deutsch‐Williams, Ralph Weissleder   +2 more
wiley   +1 more source

Poly(2-oxazoline)-Based Lipid Nanocapsules Containing Free Hydroxyl Group as Promising Alternative to Conventional PEG-Lipid Nanocapsules. [PDF]

ACS Omega
Hoang S, Dumych T, Paryzhak S, Montembault V, Fontaine L, Passirani C, Saulnier P, Krupka O.   +7 more
europepmc   +1 more source

Poster Session C18: Tumours

Brain Pathology, 2000
openaire   +2 more sources

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

Changes in egg structures during incubation and their relationship with hatchability and gosling quality in White Kołuda® and Biłgorajska geese. [PDF]

Poult Sci
Wlaźlak S, Biesek J, Pilarski K, Kowalczyk A, Banaszak M, Belka K, Adamski M.   +6 more
europepmc   +1 more source