Results 131 to 140 of about 119,425 (295)

Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia-reperfusion injury model.

, 2018
OBJECTIVE Ischemia-reperfusion (I/R) injury is a major clinical problem linked to vascular surgery. Currently, no drugs to prevent or to treat I/R injury are approved for clinical use.
Peter J. Cowan, Shaw-Boden, Jane, Adriano Taddeo, Cowan, Peter J, Zhang, Shengye, Robert Rieben, Marc W. Nolte, Rieben, Robert, Nolte, Marc W, Anjan K. Bongoni, Banz, Yara, Spirig, Rolf, Jane Shaw-Boden, Rolf Spirig, Taddeo, Adriano, Shengye Zhang, Bongoni, Anjan K, Yara Banz   +17 more
core   +1 more source

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

Hereditary angioedema: how to approach it at the emergency department?

Einstein (São Paulo)
Angioedema attacks are common causes of emergency care, and due to the potential for severity, it is important that professionals who work in these services know their causes and management.
Faradiba Sarquis Serpa, Eli Mansour, Marcelo Vivolo Aun, Pedro Giavina-Bianchi, Herberto José Chong Neto, Luisa Karla Arruda, Regis Albuquerque Campos, Antônio Abílio Motta, Eliana Toledo, Anete Sevciovic Grumach, Solange Oliveira Rodrigues Valle   +10 more
doaj   +2 more sources

Aktivierung der plasmatischen Kaskadensysteme bei Sepsis: Rolle von C1-Inhibitor

, 1999
During sepsis the complement system, the contact activation system and the coagulation cascade are activated. Activation of these plasmatic cascades contributes to the development of multiple organ failure and the high mortality rate of severe sepsis and
Zeerleder, S., Caliezi, C., Devay, J., Wuillemin, W. A., Redondo, M.   +4 more
core  

Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction

, 2015
Complement activation contributes significantly to inflammation-related damage in the heart after acute myocardial infarction. Knowledge on factors that regulate postinfraction complement activation is incomplete however.
Hans W.M. Niessen, Reindert W. Emmens, Lynda J.M. Juffermans, Niessen, Hans W. M., Karia, Rashmi V., Sacha Zeerleder, Paul A.J. Krijnen, Simsek, Suat, Ylstra, Bauke, Juffermans, Lynda J. M., Krijnen, Paul A. J., Bauke Ylstra, Marieke van Ham, Umit Baylan, Wouters, Diana, Zeerleder, Sacha, Suat Simsek, Emmens, Reindert W., Diana Wouters, Baylan, Umit, van Ham, Marieke, Rashmi V. Karia   +21 more
core   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Proteinase inhibitor therapy of severe inflammation in pigs: First results with eglin, a potent inhibitor of granulocyte elastase and cathepsin G. [PDF]

, 1986
Siebeck, Matthias, Welter, H. F., Tschesche, H., Jochum, Marianne, Fritz, Hans   +4 more
core   +1 more source

Érzékeny C1-inhibitor fehérje mérési módszer kidolgozása

, 2016
A C1-inhibitor (C1-INH) egy szerin proteáz gátló glikoprotein, ami a homeosztázis fenntartásához fontos kaszkád-szerű plazma enzim rendszerek egyik fő szabályozója.
Gulyás Dominik Ádám
core  

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source