Results 151 to 160 of about 878,820 (240)

Population-scale analysis reveals inherited C1-inhibitor deficiency is a polyphenotypic thrombotic disorder. [PDF]

Blood Adv
Rodriguez Espada A, Haj AK, Jurgens SJ, Eswaran H, Sundler Björkman L, Ryu J, Chaudhry S, Koyama S, Wang X, Choi SH, Sanna-Cherchi S, Banerji A, Rämö JT, Ellinor PT, Grover SP, Bendapudi PK.   +15 more
europepmc   +1 more source

Mechanisms involved in hereditary angioedema with normal C1-inhibitor activity. [PDF]

Front Physiol, 2023
Shamanaev A, Dickeson SK, Ivanov I, Litvak M, Sun MF, Kumar S, Cheng Q, Srivastava P, He TZ, Gailani D.   +9 more
europepmc   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Diagnostic delay, <i>SERPING1</i> allelic heterogeneity, and real-world lanadelumab prophylaxis in Chinese patients with hereditary angioedema due to C1 inhibitor deficiency. [PDF]

Front Allergy
Du W, Wang S, Yang K, Zhang Q, Lin X, Zhang W, Guo W.   +6 more
europepmc   +1 more source

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis. [PDF]

Front Immunol, 2023
Martin M, Nilsson SC, Eikrem D, Fromell K, Scavenius C, Vogt LM, Bielecka E, Potempa J, Enghild JJ, Nilsson B, Ekdahl KN, Kapetanovic MC, Blom AM.   +12 more
europepmc   +1 more source

Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis

Advanced Science, EarlyView.
Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko, Eric S. Larsen, Govind Paneru, Kisung Lee, Diana V. Kolygina, Yankai Jia, Elizabeth Maria Clarissa, Wai‐Shing Wong, Bartosz A. Grzybowski   +8 more
wiley   +1 more source

Proteinase inhibitor therapy of severe inflammation in pigs: First results with eglin, a potent inhibitor of granulocyte elastase and cathepsin G. [PDF]

, 1986
Siebeck, Matthias, Welter, H. F., Tschesche, H., Jochum, Marianne, Fritz, Hans   +4 more
core   +1 more source

Angioedema due to acquired C1 inhibitor deficiency: patient experience, conceptual disease model, and assessment of patient-reported outcome measures. [PDF]

Front Immunol
de Lange M, Cohn DM, Gobert D, Riedl MA, Zanichelli A, Brewer K, Clifford S, Pattanaik S, Romero B, Chen M, Mendivil J.   +10 more
europepmc   +1 more source

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

Comparative Efficacy of Recombinant C1 Inhibitor Versus Sebetralstat for On-Demand Treatment of Hereditary Angioedema Attacks: A Matching-Adjusted Indirect Treatment Comparison. [PDF]

Adv Ther
Anderson J, Narsipur N, Jones D, Smith A, Relan A, Aiello E, Roskell N, Gough A, Jindal S, Habimana K, Kilvert H, Li HH, Harrington A.   +12 more
europepmc   +1 more source