Results 61 to 70 of about 740,898 (340)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Multinational Mission Command: From Paper to Practice in NATO

Scandinavian Journal of Military Studies
With the 2022 update to NATO’s AJP-01 Allied Joint Doctrine, mission command was elevated from an important component of a joint command philosophy to the alliance’s overarching command philosophy – a shift in written doctrine raising concerns about its ...
Søren Sjøgren, Niklas Nilsson
doaj   +1 more source

Non-Toxic Increases in Nitrogen Availability Can Improve the Ability of the Soil Lichen Cladonia rangiferina to Cope with Environmental Changes

Journal of Fungi, 2022
Climate change and atmospheric nitrogen (N) deposition on drylands are greatly threatening these especially vulnerable areas. Soil biocrust-forming lichens in drylands can provide early indicators of these disturbances and play a pivotal role, as they ...
Lourdes Morillas, Javier Roales, Cristina Cruz, Silvana Munzi   +3 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Dysferlin C2-FerA analysis.

, 2022
A. C2-FerA domain schematic showings the secondary structure connectivity and the large insertion of the β4–5 FerA subdomain. B. SDS-PAGE showing the purified dysferlin C2-FerA domain versus molecular weight size markers. C.
Jon J. McCord (11977550), Matthew J. Dominguez (13171020), R. Bryan Sutton (69050)   +2 more
core   +1 more source

Spatial Distribution of Wettability in Aluminum Surfaces Treated with an Atmospheric-Pressure Remote-Plasma

Metals, 2019
The use of atmospheric-pressure remote plasmas (postdischarge) sustained in argon and argon−nitrogen for the treatment of aluminum surfaces has been studied to better understand the underlying mechanisms responsible for cleaning and activating the ...
José Muñoz, Rocío Rincón, María Dolores Calzada   +2 more
doaj   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

C2-Oxyanion Neighboring Group Participation: Transition State Structure for the Hydroxide-Promoted Hydrolysis of 4‑Nitrophenyl α‑d‑Mannopyranoside

, 2017
The hydroxide-catalyzed hydrolysis of aryl 1,2-trans-glycosides proceeds through a mechanism involving neighboring group participation by a C2-oxyanion and rate-limiting formation of a 1,2-anhydro sugar (oxirane) intermediate.
Gaetano Speciale (3223794), Spencer J. Williams (180548), Fahimeh S. Shidmoossavee (1913656), Marco Farren-Dai (3223797), Andrew J. Bennet (1755919)   +4 more
core   +1 more source

Framework for Climate Change Adaptation of Agriculture and Forestry in Mediterranean Climate Regions

Land, 2021
Planning the adaptation of agriculture and forestry landscapes to climate change remains challenging due to the need for integrating substantial amounts of information.
André Vizinho, David Avelar, Cristina Branquinho, Tiago Capela Lourenço, Silvia Carvalho, Alice Nunes, Leonor Sucena-Paiva, Hugo Oliveira, Ana Lúcia Fonseca, Filipe Duarte Santos, Maria José Roxo, Gil Penha-Lopes   +11 more
doaj   +1 more source

Carbon dioxide electroreduction to C2 products over copper-cuprous oxide derived from electrosynthesized copper complex

Nature Communications, 2019
Efficient electroreduction of carbon dioxide to multicarbon products in aqueous solution is of great importance and challenging. Unfortunately, the low efficiency of the production of C2 products limits implementation at scale.
Qinggong Zhu, Xiaofu Sun, Dexin Yang, Jun Ma, Xinchen Kang, Lirong Zheng, Jing Zhang, Zhonghua Wu, B. Han   +8 more
semanticscholar   +1 more source