Results 151 to 160 of about 40,889 (265)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Effects of chemogenetic inhibition of serotonergic raphe-striatal neurons on L-DOPA-induced behaviors and neurochemistry in a rat model of Parkinson's disease. [PDF]

Acta Neuropathol Commun
Budrow CN, Bernal-Conde LD, Sandoval IM, Galfano A, Grezenko H, Velazquez A, Marmion DJ, Flores-Barrera E, Venkatesh S, Coyle M, Meyers K, Nguyen K, Holden H, Tseng KY, Bishop CR, Manfredsson FP.   +15 more
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, Volume 36, Issue 4, July 2026.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Bepostastine besylate. [PDF]

IUCrdata
Salazar JK, Kaduk JA, Dosen A, Blanton TN.   +3 more
europepmc   +1 more source

Worldwide Invasions of Centrarchidae: The Dark Side of the Sunfish Family

Fish and Fisheries, Volume 27, Issue 4, Page 781-812, July 2026.
ABSTRACT Freshwater fish invasions are major drivers of global ecological change, disrupting native biodiversity and ecosystem functions. However, many invasive fish hold significant socioeconomic value, resulting in conflict over their management. Centrarchidae, which are globally distributed and are important for sportfishing and aquaculture, are now
Neil Angelo Abreo, Jonathan Tibo, António Barbosa Nogueira, Athanasios Nikolaou, Cüneyt Kaya, Ali Serhan Tarkan, Irmak Kurtul, Stelios Katsanevakis, Ronaldo Sousa, Teun Everts, Emili García‐Berthou, John S. Hargrove, Ana Clara Sampaio Franco, Jelger Erik Herder, Julian D. Olden, Darragh J. Woodford, Antonín Kouba, J. Rob Britton, Ismael Soto, Phillip J. Haubrock   +19 more
wiley   +1 more source

Synthesis and structure of (<i>Z</i>)-8-methyl-2-(8-methyl-2,3,4,9-tetra-hydro-carbazol-1-yl-idene)-2,3,4,9-tetra-hydro-carbazol-1-one. [PDF]

Acta Crystallogr E Crystallogr Commun
Sridharan M, Thiruvalluvar AA.
europepmc   +1 more source

Grandchild caregiving in Hong Kong and implications for intergenerational relationships

International Journal of Social Welfare, Volume 35, Issue 3, July 2026.
Abstract This study draws on perspectives from social exchange theory and Chinese filial piety to assess the validity of these frameworks in explaining grandchildren's caregiving behaviour. Through in‐depth interviews, data on caregiving experiences were collected from 40 grandchildren who had provided care for disabled or ill grandparents.
Chak Kwan Chan, Kong Sang Lou, Florence Meng Soi Fong, Ka Chung Kwong   +3 more
wiley   +1 more source

Synthesis, crystal structure and Hirshfeld analysis of the bis-{(<i>E</i>)-2-[1-(benzo[<i>d</i>][1,3]dioxol-5-yl)ethylidene]-<i>N</i>-ethyl-hydrazine-1-carbo-thio-amide-κ<i>S</i>}di-chlorido-mercury(II) complex. [PDF]

Acta Crystallogr E Crystallogr Commun
de Farias RL, Beck J, Daniels J, de Oliveira AB.   +3 more
europepmc   +1 more source

Satellite‐Based Assessment of Methane Emissions From the Darvaza Gas Crater

Geophysical Research Letters, Volume 53, Issue 12, 28 June 2026.
Abstract Methane is a potent greenhouse gas, and the Darvaza crater in Turkmenistan is a rare, persistent emitter. There are uncertainties regarding its formation date (either 1963 or 1971), fire ignition, and the fire's influence on methane release. Using historical Landsat imagery, we reconstruct the fire history, identifying that combustion began ...
Adriana Valverde, Itziar Irakulis‐Loitxate, Javier Gorroño, Zhipeng Pei, Javier Roger, Luis Guanter   +5 more
wiley   +1 more source

Synthesis and structure of 4-[(2,3,4,5,6-pentafluoro-phen-oxy)carbon-yl]phenyl 4-(dodec-yloxy)benzoate. [PDF]

Acta Crystallogr E Crystallogr Commun
Ahmed K, Bommalingaiah B, Venkatareddy GN, Srinivasa HT, Devarajegowda HC, Palakshamurthy BS.   +5 more
europepmc   +1 more source