Results 1 to 10 of about 27,225 (187)

The Complement C3a and C3a Receptor Pathway in Kidney Diseases [PDF]

Frontiers in Immunology, 2020
The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role.
Shuang Gao, Shuang Gao, Shuang Gao, Shuang Gao, Zhao Cui, Zhao Cui, Zhao Cui, Zhao Cui, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao   +12 more
doaj   +4 more sources

Complement C3a Enhances the Phagocytic Activity of B Cells Through C3aR in a Fish

Frontiers in Immunology, 2022
The complement system is an important part of the immune system of teleost fish. Besides, teleost B cells possess both phagocytic activity and adaptive humoral immune function, unlike mammalian B1 cells with phagocytic activity and B2 cells specific to ...
Zi-You Ma, Zi-You Ma, Zi-You Ma, Zi-You Ma, Jia-Xin Liang, Wen-Shuo Li, Yuan Sun, Chang-Song Wu, Chang-Song Wu, Chang-Song Wu, Ya-Zhen Hu, Ya-Zhen Hu, Ya-Zhen Hu, Jun Li, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Xu-Jie Zhang, Xu-Jie Zhang, Xu-Jie Zhang   +19 more
doaj   +2 more sources

Complement C3a activates astrocytes to promote medulloblastoma progression through TNF-α

Journal of Neuroinflammation, 2022
Background Medulloblastoma (MB) is the most common malignant brain tumor in children. Approximately one-third of MB patients remain incurable. Understanding the molecular mechanism of MB tumorigenesis is, therefore, critical for developing specific and ...
Biao Gong, Duancheng Guo, Chaonan Zheng, Zhen Ma, Jie Zhang, Yanghui Qu, Xinhua Li, Gen Li, Li Zhang, Yuan Wang   +9 more
doaj   +2 more sources

Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity

The Journal of Clinical Investigation, 2023
Despite advances in acute care, ischemic stroke remains a major cause of long-term disability. Approaches targeting both neuronal and glial responses are needed to enhance recovery and improve long-term outcome.
Anna Stokowska, Markus Aswendt, Daniel Zucha, Stephanie Lohmann, Frederique Wieters, Javier Morán Suarez, Alison L. Atkins, YiXian Li, Maria Miteva, Julia Lewin, Dirk Wiedermann, Michael Diedenhofen, Åsa Torinsson Naluai, Pavel Abaffy, Lukas Valihrach, Mikael Kubista, Mathias Hoehn, Milos Pekny, Marcela Pekna   +18 more
doaj   +2 more sources

Anaphylatoxin C3a receptors in asthma [PDF]

Respiratory Research, 2005
The complement system forms the central core of innate immunity but also mediates a variety of inflammatory responses. Anaphylatoxin C3a, which is generated as a byproduct of complement activation, has long been known to activate mast cells, basophils ...
Panettieri Reynold A, Ali Hydar
doaj   +4 more sources

Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy

Journal of the American Society of Nephrology, 2022
Background The complement system is highly activated in primary membranous nephropathy (MN). Identifying the complement components that damage podocytes has important therapeutic implications. This study investigated the role of C3a and the C3a receptor (C3aR) in the pathogenesis of MN.
Shuang Gao, Zhao Cui, Ming-hui Zhao
openaire   +3 more sources

Plasma complement C3 and C3a are increased in major depressive disorder independent of childhood trauma

BMC Psychiatry, 2022
Background Dysregulated complement system is linked to pathophysiology of major depressive disorder (MDD). Childhood trauma has been associated with an increased incidence of adult depression via a putative mechanism of immune activation.
Xianmei Luo, Zeman Fang, Lingyun Lin, Haiyun Xu, Qingjun Huang, Handi Zhang   +5 more
doaj   +2 more sources

C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts

Journal of Experimental & Clinical Cancer Research, 2020
Background Mounting evidence suggests that complement components promote tumor progression via modulating immune suppression, angiogenesis, or tumor cell proliferation.
Chi Shu, Haoran Zha, Haixia Long, Xinxin Wang, Fei Yang, Jianbao Gao, Chunyan Hu, Li Zhou, Bo Guo, Bo Zhu   +9 more
doaj   +2 more sources

Urinary C3 levels associated with sepsis and acute kidney injury-A pilot study.

PLoS ONE, 2021
Acute kidney injury (AKI) is an abrupt deterioration of renal function often caused by severe clinical disease such as sepsis, and patients require intensive care.
Sahra Pajenda, Florence Zawedde, Sebastian Kapps, Ludwig Wagner, Alice Schmidt, Wolfgang Winnicki, David O'Connell, Daniela Gerges   +7 more
doaj   +2 more sources

Changes of complement fragment C3a and its receptor in lung injury induced by silica nanoparticles

环境与职业医学, 2023
BackgroundSilica nanoparticles (SiNPs) enter the human body through respiratory tract, digestive tract, and skin, causing body damage. Lung is one of the main damaged organs.
Sifan ZHOU, Zhoujian WANG, Lei GAO, Yuansheng DUAN, Muyue CHEN, Jiaxiang ZHANG, Qixing ZHU   +6 more
doaj   +1 more source