Results 21 to 30 of about 27,277 (237)
Frontiers in Immunology, 2021 Complement component 3 fragment C3a is an anaphylatoxin involved in promoting cellular responses important in immune response and host defense. Its receptor (C3a receptor, C3aR) is distributed on the plasma membrane; however, lysosomal localization in ...
M. Ishii +3 more
semanticscholar +1 more source
C3aR plays both sides in regulating resistance to bacterial infections.
PLoS Pathogens, 2022 Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune cell function and outcome of bacterial infection.
Jesse A Corcoran, Brooke A Napier
doaj +2 more sources
Cells, 2022 Shiga toxin (Stx)-producing Escherichia coli is the predominant offending agent of post-diarrheal hemolytic uremic syndrome (HUS), a rare disorder of microvascular thrombosis and acute kidney injury possibly leading to long-term renal sequelae.
Simona Buelli +12 more
doaj +1 more source
Factors influencing the sulfate balance in pure phase C3S/C3A systems
, 2020 Understanding the sulfate balance mechanism of cement is needed for an effective use of sustainable blended cements. Pure phase systems allow to study the interaction between sulfate and each of the phases involved in early age hydration separately. This
F. Zunino, K. Scrivener
semanticscholar +1 more source
Journal of Clinical Investigation, 2021 Vascular dysfunction resulting in compromised blood-brain barrier (BBB) integrity is evident in aging and disease. Although the complement C3a/C3a receptor (C3a/C3aR) axis influences normal brain aging and disease progression, the mechanisms governing ...
Kanchan Bhatia +3 more
semanticscholar +1 more source
Kilogram scale synthesis of C3A polymorphs and their hydration reactions
Cement, 2023 Studies on the properties of pure C3A phases are often limited to methods requiring small sample amounts due to the lack of a convenient laboratory synthesis yielding sample amounts exceeding 100 g. Here, we report a simple and large scale lab method for
Daniel Axthammer +3 more
doaj +1 more source
Cytolysis of fibroblasts by C3a [PDF]
British Journal of Cancer, 1980 C3a was found to be more cytolytic to transformed than to primary fibroblast cultures from mouse and man. Fibroblasts made quiescent with caffeine were lysed by the same concentrations of C3a as untreated cells. These findings may have implications in tumour immunity.
A, Temple, A C, Allison
openaire +2 more sources
Endothelial C3a receptor mediates vascular inflammation and BBB permeability during aging.
Journal of Clinical Investigation, 2020 Dysfunction of immune and vascular systems has been implicated in aging and Alzheimer's disease; however, their interrelatedness remains poorly understood. The complement pathway is a well-established regulator of innate immunity in the brain.
Nicholas E. Propson +4 more
semanticscholar +1 more source
Virulence, 2019 The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Marcel Muenstermann +6 more
doaj +1 more source
Complement activation contributes to perioperative neurocognitive disorders in mice
Journal of Neuroinflammation, 2018 Background The complement system plays an important role in many neurological disorders. Complement modulation, including C3/C3a receptor signaling, shows promising therapeutic effects on cognition and neurodegeneration.
Chao Xiong +5 more
doaj +1 more source