Results 31 to 40 of about 27,277 (237)
Modulation of human lymphocyte function by C3a and C3a(70-77). [PDF]
The Journal of experimental medicine, 1982 Human C3a and the synthetic octapeptide C3a (70-77), which retains the activities of an anaphylatoxin, inhibit in a concentration-dependent manner the generation of leukocyte inhibitory factor (LIF) activity by human mononuclear leukocytes and T lymphocytes cultured with the mitogens phytohemagglutinin (PHA) or concanavalin A (Con A) or the antigen ...
Payan, DG, Trentham, DE, Goetzl, EJ
openaire +4 more sources
Journal for ImmunoTherapy of Cancer, 2021 Background Resistance to therapy is a major problem in treating head and neck squamous cell carcinomas (HNSCC). Complement system inhibition has been shown to reduce tumor growth, metastasis, and therapeutic resistance in other tumor models, but has yet ...
J. Gadwa +12 more
semanticscholar +1 more source
Scientific Reports, 2022 Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the production of a diverse array of autoantibodies and the dysfunctional activation of the complement system.
Yao-Hua Cai +6 more
doaj +1 more source
Bulletin of the National Research Centre, 2021 Background This study aimed to in vivo and in vitro evaluate the remineralization potential and shear bond strength (SBS) of experimentally prepared tri-calcium aluminate (C3A)-modified glass ionomer cements on sound and artificial caries-affected dentin
M. M. Radwan +2 more
doaj +1 more source
Antifungal activity of C3a and C3a-derived peptides against Candida
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007 Antimicrobial peptides are generated during activation of the complement system [Nordahl et al. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:16879-16884]. Here we show that the anaphylatoxin C3a exerts antimicrobial effects against the yeast Candida. Fluorescence microscopy and electron microscopy analysis demonstrated that C3a-derived peptides bound to ...
Sonesson, Andreas +5 more
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Species-specific differences in regulation of macrophage inflammation by the C3a–C3a receptor axis [PDF]
Innate Immunity, 2018 Complement is an important arm of the innate immune system. Recent studies have shown that products of complement pathway activation can interact directly with other innate immune signaling molecules, including TLRs and inflammasome family members, during some infectious and chronic inflammatory disorders.
Ray, Tathagat Dutta +5 more
openaire +2 more sources
C3a receptor blockade protects podocytes from injury in diabetic nephropathy.
JCI Insight, 2020 Renal activation of the complement system has been described in patients with diabetic nephropathy (DN), although its pathological relevance is still ill-defined.
M. Morigi +10 more
semanticscholar +1 more source
Complement inhibition promotes endogenous neurogenesis and sustained anti-inflammatory neuroprotection following reperfused stroke. [PDF]
PLoS ONE, 2012 The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent
Andrew F Ducruet +11 more
doaj +1 more source
Influence of Lithium Carbonate on C3A Hydration
Advances in Materials Science and Engineering, 2018 Lithium salts, known to ameliorate the effects of alkali-silica reaction, can make significant effects on cement setting. However, the mechanism of effects on cement hydration, especially the hydration of C3A which is critical for initial setting time of
Weiwei Han +5 more
doaj +1 more source
Cancer Biology & Medicine, 2021 Objective: Myeloma bone disease (MBD) is the most common complication of multiple myeloma (MM). Our previous study showed that the serum levels of C3/C4 in MM patients were significantly positively correlated with the severity of bone disease.
Fengjuan Jiang +12 more
doaj +1 more source